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公开(公告)号：US3737096A
公开(公告)日：1973-06-05
申请号：US3737096D
申请日：1971-12-23
Applicant: IBM
CPC classification number: B04B5/0442 , A61M1/0011 , A61M1/025 , A61M1/3692 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2202/0429
Abstract: Apparatus for processing blood, and particularly for washing blood cells, including a centrifuge head in which is arranged a flexible blood container connected by a rotating seal to tubing which permits the entrance and exit of wash liquid and supernatant. The flow of liquid in the tubing is controlled by valve arrangements which are operable to permit the entrance of wash liquid and removal of supernatant liquid. The flexible container fits over a flexible membrane also arranged inside the centrifuge head about a solid central core. The volume defined by this membrane and the core communicates via a passage in the core with a fluid reservoir by means of a control pump which allows fluid to enter and exit from the volume defined by the membrane. During operation the unwashed blood may be entered into the container or blood bag before or after the bag is placed in the centrifuge. The centrifuge is spun until cells have settled against the outside wall at which time the valve arrangements and the control pump are activated such that fluid is pumped into the centrifuge under the volume defined by the membrane thereby forcing a supernatant to flow out to a collect container. The centrifuge is then stopped and the wash solution enters the blood container through another valve arrangement, thereby allowing the removal of fluid from the volume inside the flexible membrane. Removal of the wash liquid is accomplished by the same process of removal as the removal of supernatant previously described. Provisions are made for electrical control of all the operations including an agitate operation in which the centrifuge is spun in alternate directions for only a few revolutions or goes through alternate accelerate-decelerate cycles while rotating in the same direction to thereby agitate the material in the blood bag or flexible container during the time that a wash solution is entering. The circuit arrangements are such that a high degree of flexibility in the programming of the various operations can be obtained.
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公开(公告)号：ZA7802114B
公开(公告)日：1979-11-28
申请号：ZA7802114
申请日：1978-04-12
Applicant: IBM
CPC classification number: B04B5/0442 , B04B2005/045
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公开(公告)号：ZA782114B
公开(公告)日：1979-11-28
申请号：ZA782114
申请日：1978-04-12
Applicant: IBM
Abstract: An improved centrifuge assembly comprising a channeled rotor assembly and a ring-like fluid container disposed in the channel, whereby the centrifugal separation effects in the fluid container are determined by the geometry of the channel in the rotor. The fluid container is preferably formed from semirigid plastic material in the form of a tube having a rectangular cross section and is considered a disposable item to be discarded after a single use. The rotor assembly preferably includes a removable filler piece or center piece formed from a single piece of material, such as rigid plastic, as by molding, dimensioned to form, with the wall of the centrifuge bowl, a circular channel having dimensions appropriate to receive the semirigid container, which is suitably bent and placed in the channel. Fluid connections are provided from each end of the container to an axially located multichannel rotating seal. The connections lie in a plurality of radial slots in the filler piece. Alternatively the entire assembly may be molded as a single entity, with a suitable channel and fluid line grooves being cast therein.
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