公开(公告)号：WO2006138171A3

公开(公告)日：2007-07-12

申请号：PCT/US2006022526

申请日：2006-06-09

Applicant: IMALUX CORP

Inventor： PIYEVSKY SERGEY M ,  FELDCHTEIN FELIX I ,  GELIKONOV GRIGORY V

IPC: G02B6/26

CPC classification number: G02B6/3502 ,  G02B6/32 ,  G02B6/3572 ,  G02B26/10

Abstract: An optical fiber magnetic scanning arrangement for a miniature optical fiber probe is provided for various optical imaging applications. The magnetic system includes a permanent magnet piece with a magnetization direction substantially orthogonal to the own axis of the optical fiber. The permanent magnet piece extends in a direction substantially aligned with the own axis of the optical fiber, wherein the current conductor loop is adjacent an inner surface of the permanent magnet piece. In another embodiment, the permanent magnet is of a hollow cylinder type with a radial magnetization direction. The permanent magnet cylinder extends in a direction substantially aligned with the own axis of the optical fiber, the current conductor loop being placed inside the permanent magnet cylinder. The designs provide a potential for further miniaturization.

Abstract translation: 提供用于微型光纤探针的光纤磁扫描装置用于各种光学成像应用。 该磁性系统包括具有与光纤的自身轴线基本正交的磁化方向的永久磁铁片。 永久磁铁片沿着与光纤的自身轴线基本对齐的方向延伸，其中电流导体环邻近永磁体片的内表面。 在另一个实施例中，永磁体是具有径向磁化方向的中空圆筒型。 永久磁铁圆筒在与光纤的自身轴线基本上对准的方向上延伸，电流导体环放置在永久磁铁圆筒的内部。 这些设计提供了进一步小型化的潜力。

公开(公告)号：WO2008030923A3

公开(公告)日：2008-05-22

申请号：PCT/US2007077706

申请日：2007-09-06

Applicant: IMALUX CORP

Inventor： AMAZEEN PAUL G ,  FELDCHTEIN FELIX I

IPC: G01B9/02

CPC classification number: G01N21/4795

Abstract: Provided are common path frequency domain and time domain OCT systems and methods that use non-specular reference reflection for obtaining internal depth profiles and depth resolved images of samples. Further provided is a delivering device for optical radiation, preferably implemented as an optical fiber probe with a partially optically transparent non-specular reflector placed in the vicinity of an associated sample. High frequency fringes are substantially reduced and a stable power level of the reference reflection is provided over the lateral scanning range. The partially optically transparent non-specular reflector is implemented as a coating placed on the interior surface of the optical probe window including spots of a metal, or a dielectric coating, separated by elements of another coating or just spaces of a clean substrate. In an alternative embodiment, the scattering elements are made 3-dimentional, having, for example, a spherical shape.

Abstract translation: 提供了通用路径频域和时域OCT系统和方法，其使用非镜面参考反射来获得样本的内部深度分布和深度分辨图像。 还提供了用于光辐射的递送装置，优选地实现为具有放置在相关样品附近的部分光学透明的非镜面反射器的光纤探针。 高频条纹基本上减少，并且横向扫描范围提供参考反射的稳定功率水平。 部分光学透明的非镜面反射器被实施为放置在光学探针窗口的内表面上的涂层，包括由另一涂层的元件或洁净基底的空间分开的金属或电介质涂层的斑点。 在替代实施例中，散射元件制成3维，具有例如球形。

公开(公告)号：WO2005124296A2

公开(公告)日：2005-12-29

申请号：PCT/US2005021210

申请日：2005-06-15

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I ,  BREEDLOVE J LLOYD ,  HARRINGTON STEPHANIE A S

IPC: G01J1/10 ,  G01N21/27 ,  G01N21/47

CPC classification number: G01N21/274 ,  G01N21/27 ,  G01N21/278 ,  G01N21/4795

Abstract: An optical measurement device calibration tool includes an optical probe suitable for calibrating various optical imaging devices, for example, low coherence reflectometers and optical coherence tomography devices. In a preferred embodiment the calibration tool comprises a container containing a calibration substance with stable optical scattering and absorption properties. The calibration substance includes a gel, paste or grease substance and is covered a protective seal, which is at least partially transparent providing optical contact between the optical probe and the calibration substance. The protective seal is covered with a viscous complementary material. Another protective seal made at least partially removable is placed above the viscous complementary material and may serve as a cover for the container. The calibration tool maintains the advantages of calibration tools using liquids and solid states as calibration substance and is more cost-effective and more convenient for calibrating optical measuring devices such as in medical applications.

Abstract translation: 光学测量装置校准工具包括适于校准各种光学成像装置的光学探针，例如低相干反射计和光学相干断层摄影装置。 在优选实施例中，校准工具包括容纳具有稳定的光散射和吸收特性的校准物质的容器。 校准物质包括凝胶，糊状物或油脂物质，并被覆盖保护性密封，该保护性密封件至少部分透明，提供光学探针与校准物质之间的光学接触。 保护性密封件用粘性补充材料覆盖。 至少部分可移除的另一个保护性密封件放置在粘性互补材料的上方，并可用作容器的盖子。 校准工具保持了使用液体和固态作为校准物质的校准工具的优点，并且对于诸如医疗应用中的光学测量装置的校准更具成本效益和更方便。

公开(公告)号：WO2008024741A3

公开(公告)日：2008-06-26

申请号：PCT/US2007076369

申请日：2007-08-21

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  G01B9/02057 ,  G01B2290/70 ,  G01N21/4795

Abstract: In common path time domain OCT/OCR devices optical radiation from a source is first split into two replicas, which are then delivered to an associated sample by an optical fiber probe. The tip of the optical fiber probe serves as a reference reflector and also serves as a combining element that produces a combination optical radiation by combining an optical radiation returning from the associated sample with a reference optical radiation reflected from the reference reflector. The topology of the devices eliminates the necessity of using Faraday mirrors, and also allows for registering a cross-polarized component of the optical radiation reflected or backscattered from the associated sample, as well as a parallel-polarized component.

Abstract translation: 在公共路径时域OCT / OCR设备中，首先将来自光源的光辐射分成两个副本，然后通过光纤探头将其传递到相关样本。 光纤探针的尖端用作参考反射器并且还用作通过将从相关联的样本返回的光辐射与从参考反射器反射的参考光辐射组合而产生组合光辐射的组合元件。 器件的拓扑消除了使用法拉第反射镜的必要性，并且还允许记录从相关样品反射或反向散射的光辐射的交叉偏振分量以及平行偏振分量。

公开(公告)号：WO2007008788A3

公开(公告)日：2009-04-30

申请号：PCT/US2006026721

申请日：2006-07-10

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I ,  GELIKONOV GRIGORY V

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02065 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02078 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

Abstract: Common path frequency domain optical coherence reflectometry/tomography devices with an additional interferometer are suggested. The additional interferometer offset is adjusted such, that it is ether less than the reference offset, or exceeds the distance from the reference reflector to the distal boundary of the longitudinal range of interest. This adjustment allows for relieving the requirements to the spectral resolution of the frequency domain optical coherence reflectometry/tomography engine and/or speed of the data acquisition and processing system, and eliminates depth ambiguity problems. The new topology allows for including a phase or frequency modulator in an arm of the additional interferometer improving the signal-to-noise ratio of the devices. The modulator is also capable of substantially eliminating mirror ambiguity, DC artifacts, and autocorrelation artifacts. The interference signal is produced either in the interferometer or inside of the optical fiber probe leading to the sample.

Abstract translation: 建议使用带有附加干涉仪的共路径频域光学相干反射/断层成像装置。 调整附加的干涉仪偏移，使得其比参考偏移小，或者超过距参考反射器到感兴趣的纵向范围的远端边界的距离。 该调整允许缓解对频域光学相干反射/断层摄影引擎的光谱分辨率和/或数据采集和处理系统的速度的要求，并消除深度歧义问题。 新的拓扑结构允许在附加干涉仪的臂中包括相位或频率调制器来提高器件的信噪比。 调制器还能够基本上消除镜像歧义，DC伪影和自相关伪影。 在干涉仪中产生干涉信号，或者在通过样品的光纤探针的内部产生干扰信号。

公开(公告)号：WO2007059479A3

公开(公告)日：2008-11-06

申请号：PCT/US2006060856

申请日：2006-11-14

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I ,  GELIKONOV VALENTIN M ,  GELIKONOV GRIGORY V

IPC: G01B9/02

CPC classification number: G01B9/02057 ,  G01B9/0201 ,  G01B9/02011 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/49

Abstract: Polarization-sensitive optical coherence devices for obtaining birefringence information are presented. The polarization state of the optical radiation outgoing from the optical radiation source is controlled such that the polarization state of the optical radiation incident on a sample has a 45 degrees angle with respect to the anisotropy axis of the sample. A combination optical radiation is produced in a secondary interferometer by combining a sample portion with a reference portion of optical radiation reflected from a tip of an optical fiber of the optical fiber probe. Subject to a preset optical path length difference of the arms of the secondary interferometer, a cross-polarized, and/or a parallel-polarized component of the combined optical radiation, are selected. Time domain and frequency domain registration are provided. The performance of the device is substantially independent from the orientation of the optical fiber probe with respect to the sample.

Abstract translation: 提出了用于获得双折射信息的偏振敏感光学相干装置。 控制从光辐射源出射的光辐射的偏振状态，使得入射到样品上的光辐射的偏振状态相对于样品的各向异性轴具有45度的角度。 通过将样品部分与从光纤探针的光纤的尖端反射的光辐射的参考部分组合，在二次干涉仪中产生组合光辐射。 受到二次干涉仪的臂的预设光程长度差异，组合光辐射的交叉极化和/或平行偏振分量的选择。 提供时域和频域注册。 器件的性能基本上与光纤探针相对于样品的取向无关。

公开(公告)号：WO2008045771A3

公开(公告)日：2008-08-14

申请号：PCT/US2007080518

申请日：2007-10-05

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I

IPC: G01C19/70

CPC classification number: G02B26/108 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/6852

Abstract: A forward looking optical fiber probe includes an optoelectronic lateral scanner that provides circular scanning using a single pass-through optical motor and a single rotating deflector. The optical fiber is kept stationary while circular scanning is provided by an optically transparent rotating deflector intersected by the optical radiation. The arrangement allows for hermetically sealing the optical fiber probe for disinfection, sterilization and clinical use in a clean environment in general. The design is suited to be used in a miniature forward looking optical fiber probe and has a potential for advanced manufacturing and assembling process.

Abstract translation: 前视光纤探头包括光电横向扫描器，其使用单个直通光学电机和单个旋转偏转器提供圆形扫描。 光纤保持静止，同时通过与光辐射相交的光学透明旋转偏转器提供圆形扫描。 该布置允许在一般的清洁环境中密封光纤探针以进行消毒，灭菌和临床应用。 该设计适用于微型前视光纤探头，具有先进的制造和组装工艺的潜力。

公开(公告)号：WO2007059485A3

公开(公告)日：2008-07-03

申请号：PCT/US2006060868

申请日：2006-11-14

Applicant: IMALUX CORP

Inventor： FELDCHTEIN FELIX I ,  GELIKONOV VALENTIN M ,  GELIKONOV GRIGORY V

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02057 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/21 ,  G01N2021/4792

Abstract: Polarization sensitive common path OCT/OCR devices are presented. Optical radiation from a source is converted into two cross-polarized replicas propagating therethrough with a predetermined optical path length difference. The two cross-polarized replicas are then delivered to an associated sample by a delivering device, which is, preferably, an optical fiber probe. A combination optical radiation is produced in at least one secondary interferometer by combining a corresponding portion of an optical radiation returning from the associated sample with a reference optical radiation reflected from a tip of an optical fiber of the optical fiber probe. Subject to a preset optical path length difference of the arms of the at least one secondary interferometer, a cross-polarized component, and/or a parallel-polarized component of the combined optical radiation, are selected. The topology of the devices allows for time domain, as well as for frequency domain registration.

Abstract translation: 介绍了极化敏感的通用路径OCT / OCR设备。 来自源的光学辐射被转换为以预定的光程长度差传播通过其中的两个交叉极化复制品。 然后通过递送装置将两个交叉极化复制品递送到相关样品，该装置优选地是光纤探针。 通过将从相关样品返回的光学辐射的对应部分与从光纤探针的光纤的尖端反射的参考光辐射组合，在至少一个次级干涉仪中产生组合光辐射。 受到所述至少一个次级干涉仪的臂的预设光程长度差异，组合光辐射的交叉偏振分量和/或平行偏振分量的选择。 设备的拓扑结构允许时域，以及频域注册。