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    PERFLUORINATED-ETHER COMPOSITIONS AS DIAGNOSTIC CONTRAST AGENTS
    1.
    发明申请
    PERFLUORINATED-ETHER COMPOSITIONS AS DIAGNOSTIC CONTRAST AGENTS 审中-公开
    全氟化合物作为诊断对比剂

    公开(公告)号：WO1998023298A1

    公开(公告)日：1998-06-04

    申请号：PCT/US1997019900

    申请日：1997-11-03

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, evan, C.

    IPC: A61K49/04

    CPC classification number: A61K49/223

    Abstract: Compositions and methods for providing an image of an internal region of a patient. Embodiments of the invention involve vesicle compositions comprising, in an aqueous carrier, a perfluorinated ether compound and vesicles comprising one or more stabilizing compounds. The compositions may be administered to a patient, and the patient may be scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of an internal region.

    Abstract translation: 用于提供患者内部区域的图像的组合物和方法。 本发明的实施方案涉及囊泡组合物，其在水性载体中包含全氟化醚化合物和包含一种或多种稳定化合物的囊泡。 可以将组合物施用于患者，并且可以使用诸如超声波的诊断成像来扫描患者，以获得内部区域的可视图像。

    METHODS AND APPARATUS FOR PERFORMING DIAGNOSTIC AND THERAPEUTIC ULTRASOUND SIMULTANEOUSLY
    2.
    发明申请
    METHODS AND APPARATUS FOR PERFORMING DIAGNOSTIC AND THERAPEUTIC ULTRASOUND SIMULTANEOUSLY 审中-公开
    用于同时执行诊断和治疗超声的方法和装置

    公开(公告)号：WO1996039079A1

    公开(公告)日：1996-12-12

    申请号：PCT/US1996007621

    申请日：1996-05-24

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  YELLOWHAIR, David, W.

    IPC: A61B08/00

    CPC classification number: A61B8/12 ,  A61B8/0833 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61K41/0028 ,  A61K49/223 ,  A61N7/00 ,  G01S15/8925 ,  G01S15/899

    Abstract: Methods and apparatus (12-102) for performing diagnostic ultrasound simultaneously with the application of therapeutic ultrasonic waves are disclosed. The methods and apparatus (12-102) are particularly advantageous in performing ultrasonic imaging of a region of a patient while simultaneously applying therapeutic ultrasonic waves to the region for the purpose of rupturing vesicles administered to that region for purposes such as enhanced cavitation or the targeted release of a bioactive agent into the region. An operator is able to monitor the rupture of vesicles in real time.

    Abstract translation: 公开了与应用治疗超声波同时执行诊断超声的方法和装置（12-102）。 方法和装置（12-102）在对患者的区域进行超声波成像同时对该区域施加治疗性超声波以便为了破坏施用于该区域的囊泡的目的而特别有利，例如增强的空化或靶向 将生物活性剂释放到该区域。 操作者能够实时监测囊泡破裂。

    STABILIZED HOMOGENOUS SUSPENSIONS AS COMPUTED TOMOGRAPHY CONTRAST AGENTS
    3.
    发明申请
    STABILIZED HOMOGENOUS SUSPENSIONS AS COMPUTED TOMOGRAPHY CONTRAST AGENTS 审中-公开
    作为计算机对比剂的稳定的均质悬浮液

    公开(公告)号：WO1995032005A1

    公开(公告)日：1995-11-30

    申请号：PCT/US1995006491

    申请日：1995-05-22

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/04

    CPC classification number: A61K49/1806 ,  A61K49/0419

    Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas-filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.

    Abstract translation: 新型稳定的气体悬浮液作为诊断造影剂，包括计算机断层扫描（CT）和磁共振（MR）造影剂。 在优选的实施方案中，悬浮液包含稳定的充气微球。 同样在一些优选的实施方案中，至少一部分气体来自气态前体。

    NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE
    4.
    发明申请
    NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE 审中-公开
    用于诊断和治疗用途的新目标组合物

    公开(公告)号：WO1996040285A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996009938

    申请日：1996-06-06

    Applicant: IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  SHEN, Dekang ,  WU, Guanli

    Inventor： IMARx PHARMACEUTICAL CORP.

    IPC: A61K49/00

    CPC classification number: B82Y5/00 ,  A61K49/0002 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228

    Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

    Abstract translation: 可用于诊断和治疗用途的新型靶向组合物。 组合物可以包含与靶向配体组合的脂质，蛋白质或聚合物和气体。 靶向配体靶向组织，细胞或受体，包括心肌细胞，内皮细胞，上皮细胞，肿瘤细胞和糖蛋白GPIIbIIIa受体。 造影剂可以与诸如超声波的诊断成像结合使用，以及诸如治疗性超声的治疗应用。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR
    6.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR 审中-公开
    涉及使用对比剂和冠状血管扩张剂的诊断成像的改进方法

    公开(公告)号：WO1998010799A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997014986

    申请日：1997-08-26

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/04

    CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

    Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

    Abstract translation: 用于提供患者，特别是心血管区域的内部区域的图像的改进方法。 本发明的实施方案涉及向患者施用造影剂，其包含与冠状血管扩张剂组合的包含脂质或聚合物囊泡和气体或气体前体的囊泡组合物。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 该方法对于诊断患者的心血管区域中的患病组织的存在以及用于测量患者的心血管区域中的血流量是特别有用的。

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