公开(公告)号：US12181448B2

公开(公告)日：2024-12-31

申请号：US17129211

申请日：2020-12-21

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Chengxun Liu ,  Andim Stassen ,  Ying Ting Set

IPC: G01N30/00 ,  B01L3/00 ,  B03C5/02

Abstract: A method for continuously separating components from a sample includes providing a field-flow fractionation device including: a channel coupled to a flow generator for translocating the sample components along the channel in a first direction, an actuator for translocating the sample components in a second direction, at an angle with the first direction, and an array of electrodes electrically or capacitively connected to an AC power source, operating the actuator so as to translocate the sample components in a second direction at an angle with the first direction, operating the AC power source so as to generate an AC electric field between adjacent rows, and operating the flow generator, collecting sample components from the sample outlets.

公开(公告)号：US11454583B2

公开(公告)日：2022-09-27

申请号：US17133771

申请日：2020-12-24

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Chengxun Liu ,  Andim Stassen ,  Ying Ting Set

IPC: G01N15/10 ,  G01N15/00

Abstract: An example includes a field-flow fractionation device for the continuous separation of sample components including a channel comprising a sample inlet and a plurality of sample outlets, the channel being for coupling to a flow generator for translocating the sample components along the channel in a first direction from the sample inlet to the plurality of sample outlets, an actuator, which is not the flow generator, coupled to the channel, for translocating the sample components in a second direction, at a first angle with the first direction, an array of electrodes for connection to an AC power source, being in a path taken by the sample components in the channel, arranged in a plurality of rows, and in such a way that adjacent rows can be set at different potentials and every other row can be set at the same potential.

公开(公告)号：US20210199556A1

公开(公告)日：2021-07-01

申请号：US17133771

申请日：2020-12-24

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Chengxun Liu ,  Andim Stassen ,  Ying Ting Set

IPC: G01N15/10

Abstract: An example includes a field-flow fractionation device for the continuous separation of sample components including a channel comprising a sample inlet and a plurality of sample outlets, the channel being for coupling to a flow generator for translocating the sample components along the channel in a first direction from the sample inlet to the plurality of sample outlets, an actuator, which is not the flow generator, coupled to the channel, for translocating the sample components in a second direction, at a first angle with the first direction, an array of electrodes for connection to an AC power source, being in a path taken by the sample components in the channel, arranged in a plurality of rows, and in such a way that adjacent rows can be set at different potentials and every other row can be set at the same potential.

公开(公告)号：US20210199623A1

公开(公告)日：2021-07-01

申请号：US17129211

申请日：2020-12-21

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Chengxun Liu ,  Andim Stassen ,  Ying Ting Set

IPC: G01N30/00 ,  B01L3/00 ,  B03C5/02

Abstract: A method for continuously separating components from a sample includes providing a field-flow fractionation device including: a channel coupled to a flow generator for translocating the sample components along the channel in a first direction, an actuator for translocating the sample components in a second direction, at an angle with the first direction, and an array of electrodes electrically or capacitively connected to an AC power source, operating the actuator so as to translocate the sample components in a second direction at an angle with the first direction, operating the AC power source so as to generate an AC electric field between adjacent rows, and operating the flow generator, collecting sample components from the sample outlets.

公开(公告)号：US10267733B2

公开(公告)日：2019-04-23

申请号：US15312116

申请日：2015-05-22

Applicant: IMEC VZW

Inventor： Pol Van Dorpe ,  Liesbet Lagae ,  Peter Peumans ,  Andim Stassen ,  Philippe Helin ,  Bert Du Bois ,  Simone Severi

IPC: G01N21/64 ,  G01N21/77

Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.

公开(公告)号：US20170082544A1

公开(公告)日：2017-03-23

申请号：US15312116

申请日：2015-05-22

Applicant: IMEC VZW

Inventor： Pol Van Dorpe ,  Liesbet Lagae ,  Peter Peumans ,  Andim Stassen ,  Philippe Helin ,  Bert Du Bois ,  Simone Severi

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7703 ,  G01N2201/0873

Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.