Abstract:
The invention relates to an imaging device (1) comprising a photonic integrated circuit (2). This photonic integrated circuit comprises an integrated waveguide (4) for guiding a light signal (5), a light coupler (8) optically coupled to the integrated waveguide (4) and adapted for directing the light signal (5) out of the plane of the waveguide (4) as a light beam (9), and a microfluidic channel (98) for containing an object (12) immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the device, illumination of the object by the light beam. The integrated circuit further comprises at least one imaging detector (11) positioned for imaging the object (12) illuminated by the light beam (9). The invention also relates to a corresponding method for imaging.
Abstract:
An apparatus for performing in-line lens-free digital holography of an object, comprising: • - a single point light source (2) adapted for emitting coherent light; • - an image sensing device (5) adapted and arranged for recording interference patterns wherein • - the point light source comprises a broad wavelength spectrum light source and a pinhole structure, • - the image sensing device is adapted for receiving and recording, at the same moment in time, a plurality of interference patterns by a respective plurality of disjoint subsets of pixels (I, II, III, IV); • - the image sensing device comprises for each of the disjoint subsets of pixels, a respective narrow band wavelength filter positioned above each of the pixels of the disjoint subset of pixels, wherein a wavelength range of each narrow band wavelength filter falls within the broad wavelength spectrum of the point light source, these wavelength ranges of the narrow band wavelength filters being non-overlapping;
Abstract:
A method for holographic imaging of an object (106) comprises: driving (302) a laser (102) using a current which is below a threshold current of the laser (102); illuminating (304) the object (106) using illumination light (104) output by the laser (102); and detecting (306) an interference pattern formed by object light, having interacted with the object (106), and reference light of the illumination light (104). An imaging system (100) for holographic imaging is also provided.
Abstract:
A lens-free device (100) for performing drug screening on cells (103) comprises a substrate (101) having a surface (102); a light source (104) positioned to illuminate the cells (103), when present, on the substrate surface (104) with a light wave; a sensor (105) positioned to detect an optical signal caused by illuminating the cells (103). The substrate surface (102) furthermore comprises a microelectrode array for sensing electrophysiological signals from the cells (103). Further, a method for performing drug screening on cells is presented.
Abstract:
An imaging device for in-line holographic imaging of an object (110) comprises: a set of light sources (102), wherein each light source (102) is configured to output light in a confined illumination cone; an image sensor (120), which comprises a set of light-detecting elements (122) for detecting incident light, wherein the set of light sources (102) are configured to output light such that the confined illumination cone of each light source (102) illuminates a specific part of the object (110); and wherein the light-detecting elements (122) detect a plurality of interference patterns, wherein each interference pattern is formed by diffracted light from the object (110) originating from a single light source (102) and undiffracted light from the same single light source (102), wherein at least a sub-set of light-detecting elements (122) is arranged to detect light relating to not more than one interference pattern.
Abstract:
A lens-free device (100) for imaging one or more objects (106), the lens-free device comprising: a light source (102) positioned for illuminating at least one object (106); a detector (103) positioned for recording interference patterns of the illuminated at least one object (106); wherein the light source (102) comprises a plurality of light emitters (104) that are positioned and configured to create a controlled light wavefront (105) for performing lens-free imaging.
Abstract:
The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.
Abstract:
A device (1) for detecting particles in air; said device (1) comprising: a receiver (10) for receiving a flow of air (12) comprising particles (2); a particle capturing arrangement (20) configured to transfer the particles (2) from the flow of air (12) to a liquid for collection of a set of particles (2) in the liquid; a flow channel (30) configured to pass a flow of the liquid comprising the set of particles (2) through the flow channel; a light source (40) configured to illuminate the set of particles (2) in the flow channel, such that an interference pattern is formed by interference between light being scattered by the set of particles (2) and non-scattered light from the light source; and an image sensor (50) comprising a plurality of photo-sensitive elements (52) configured to detect incident light, the image sensor (50) being configured to detect the interference pattern.
Abstract:
A collector (60, 90, 100) for collecting particles (2) in air, said collector (60, 90, 100) comprising: a substrate (61), which is adapted to enable imaging of the particles (2); an adhesive layer (65) arranged on a collector side (62) of the substrate (61), said adhesive layer (65) being formed by an adhesive material; a protection element (67), which is configured to protect the adhesive layer (65) before collection of particles (2); wherein the collector (60, 90, 100) is configured to allow release of protection of the adhesive layer (65) by the protection element (67) to expose an adhesive surface (66) of the adhesive layer (65) to ambient air for collecting particles (2) on the adhesive surface (66); and wherein the collector (60, 90, 100) is further configured for presenting a particle sample carrier (70) having a smooth top surface (68) and a smooth bottom surface (69) for preventing light from being diffusely scattered by the particle sample carrier (70).
Abstract:
An imaging device for in-line holographic imaging of an object (110) comprises: a set of light sources (102), wherein each light source (102) is configured to output light in a confined illumination cone; an image sensor (120), which comprises a set of light-detecting elements (122) for detecting incident light, wherein the set of light sources (102) are configured to output light such that the confined illumination cone of each light source (102) illuminates a specific part of the object (110); and wherein the light-detecting elements (122) detect a plurality of interference patterns, wherein each interference pattern is formed by diffracted light from the object (110) originating from a single light source (102) and undiffracted light from the same single light source (102), wherein at least a sub-set of light-detecting elements (122) is arranged to detect light relating to not more than one interference pattern.