公开(公告)号：CA1253494A

公开(公告)日：1989-05-02

申请号：CA462599

申请日：1984-09-06

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： GRIECO PAUL A

IPC: A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D317/72 ,  C07C177/00

Abstract: 12,16 - DIFLUOROPROSTAGLANDIN F2.alpha. COMPOUNDS This invention relates to novel 12,16-difluoroprostaglandin F2.alpha. compounds having leuteolytic activity.

公开(公告)号：CA2204361A1

公开(公告)日：1996-05-17

申请号：CA2204361

申请日：1995-11-03

Applicant: INDIANA UNIVERSITY FOUNDATION ,  PURDUE RESEARCH FOUNDATION ,  UNIV WAYNE STATE

Inventor： CORBETT THOMAS H ,  VALERIOTE FREDERICK A ,  GRIECO PAUL A ,  MORRE JAMES D

IPC: C07D493/04 ,  A01N43/16 ,  A01N43/90 ,  A01N65/00 ,  A61K31/35 ,  A61K31/365 ,  A61K31/366 ,  A61P31/12 ,  A61P35/00 ,  C07D493/08 ,  C07D493/10

Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.