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公开(公告)号：GB1198379A
公开(公告)日：1970-07-15
申请号：GB5874668
申请日：1968-12-10
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: 1,198,379. Dentifrices. INDIANA UNIVERCITY FOUNDATION. 10 Dec., 1968, No. 58746/68. Heading A5B. [Also in Division Cl] In Zr F, may be added to dentifrice compositions to yield anticariogenic properties. Preferably ionically compatible adjunctives are used; zirconium silicate, calcium pyrophosphate, insoluble metaphosphates, alumina and resinous materials have been used as abrasives, being between 0.5-95% by weight of the total composition. The conventional binder substances, thickening agents, sudsing agents, humectants, flavoring and sweetening agents may also be added. The toxicity of In Zr F 7 in mice is shown to be less than 3 times the toxicity of NaF, In Zr F 7 is more soluble and its solutions more stable than prior art anticariogenic agents
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公开(公告)号：AT13809T
公开(公告)日：1985-07-15
申请号：AT82301093
申请日：1982-03-04
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES , REAM RONALD LEE , KLEBER CARL JOSEPH , MOORE DAVID MILTON
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公开(公告)号：AT270871B
公开(公告)日：1969-05-12
申请号：AT544964
申请日：1964-06-24
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: The novel compound stannous fluorozirconate, SnZrF6, may be prepared by reacting equimolar quantities of SnF2 and ZrF4 in aqueous solution and isolating the product by evaporation. Alternatively, SnF2 and ZrF4 may be heat-fused. The white, water-soluble crystals of SnZrF6 may be incorporated in oral compositions since the compound has high anticaries efficacy.ALSO:An oral composition for caries prophylaxis comprises 0.1 to 50% of stannous fluorozirconate, SnZrF6, and an ionically compatible carrier. Dentifrice compositions, containing say 0.1 to 1% SnZrF6, incorporate abrasives such as particulate condensation products of melamine and urea or formaldehyde, calcium pyrophosphate, calcium, metaphosphate, calcium oxyapatite, b -and a - tricalcium orthophosphates, insoluble metaphosphates and alumina, together with a foaming agent, binder and flavouring. Colloidal magnesium silicate and a humectant may also be included. The pH values of the aqueous oral compositions are preferably in the range 4.0 to 5.5.
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公开(公告)号：DE1252849B
公开(公告)日：1967-10-26
申请号：DEJ0026108
申请日：1964-06-26
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: The novel compound stannous fluorozirconate, SnZrF6, may be prepared by reacting equimolar quantities of SnF2 and ZrF4 in aqueous solution and isolating the product by evaporation. Alternatively, SnF2 and ZrF4 may be heat-fused. The white, water-soluble crystals of SnZrF6 may be incorporated in oral compositions since the compound has high anticaries efficacy.ALSO:An oral composition for caries prophylaxis comprises 0.1 to 50% of stannous fluorozirconate, SnZrF6, and an ionically compatible carrier. Dentifrice compositions, containing say 0.1 to 1% SnZrF6, incorporate abrasives such as particulate condensation products of melamine and urea or formaldehyde, calcium pyrophosphate, calcium, metaphosphate, calcium oxyapatite, b -and a - tricalcium orthophosphates, insoluble metaphosphates and alumina, together with a foaming agent, binder and flavouring. Colloidal magnesium silicate and a humectant may also be included. The pH values of the aqueous oral compositions are preferably in the range 4.0 to 5.5.
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公开(公告)号：GB1088216A
公开(公告)日：1967-10-25
申请号：GB2098366
申请日：1966-05-11
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: A prophylactic dental paste composition comprises zirconium silicate as a cleaning and polishing agent and a fluoride-containing anti-cariogenic adjuvant, e.g. NaF, SnF4, KF, InF3, PdF2, FeF2, LiF, Na2SiF6, CaZrF6, Na2ZrF6, K2ZrF6, NaSnF3, NaBF4, NaTiF5, K2GeF6, Zr(GeF6)2, SnClF, Sn2ClF3 and preferably SnZrF6 and SnF2. Alternatively, the zirconium silicate is formulated as a base composition so that a freshly prepared aqueous solution of the anticariogenic component may be admixed therewith prior to use. The base compositions also include conventional bleaching pigments, e.g. TiO2; binders or thickeners, humectants and flavouring agents including sweeteners. In both types of composition, the final product preferably contains 0.50-2.4 parts by weight of zirconium silicate and 0.05-1 parts by weight of fluoride-containing anticariogenic adjuvant.
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Patent Agency Ranking
公开(公告)号：GB1260332A
公开(公告)日：1972-01-12
申请号：GB1573669
申请日：1969-03-26
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: 1,260,332. Dentifrice. INDIANA UNIVERSITY FOUNDATION. 26 March, 1969, No. 15736/69. Heading A5B. An anticalculus dentifrice composition comprises as a cleaning and polishing agent zirconium silicate, ZrSiO 4 , having a distribution of mean diameter particle sizes in the range up to 8 microns together with a carrier suitable for use in the oral cavity. The composition may also contain calcium pyrophosphate; anhydrous calcium hydrogen phosphate; calcium hydrogen phosphate dihydrate; substantially water-impervious, cross-linked; thermosetting, highly polymerized synthetic resins; insoluble sodium metaphosphate; calcium carbonate; mixtures of talc and at least a minor amount of tremolite, CaMg 3 (SiO 3 ) 4 ; condensation products of NH 3 and P 4 O 10 ; fluoride-containing anticariogenic adjuvants; and other conventional additives.
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公开(公告)号：AU1306170A
公开(公告)日：1971-09-30
申请号：AU1306170
申请日：1970-03-25
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: 1,252,545. Chewing gum dentifrice. INDIANA UNIVERSITY FOUNDATION. 16 April, 1970 [16 April, 1969], No. 18183/70. Heading A5B. A composition for cleaning and caring for the teeth comprises a chewing gum base and a polishing agent comprising at least 20% by weight fine (up to 3 microns) and 5-40% coarse (10-20 microns) zirconium silicate (Zr SiO 4 ), the weight ratio of agent to gum base being up to 3:2. Preferably, the composition comprises up to 5% by weight of a dental plaque removing agent, e.g. Na 2 CO 3 , NaHCO 3 or CHCl 3 , and the fine ZrSiO, is in the form of relatively smooth particles whereas the coarse particles are relatively rough.
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公开(公告)号：GB1245288A
公开(公告)日：1971-09-08
申请号：GB3201870
申请日：1968-12-10
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: 1,245,288. Zirconyl hexafluorogermanate. INDIANA UNIVERSITY FOUNDATION. 10 Dec., 1968, No. 32018/70. Divided out of 1,245,287. Heading C1A. [Also in Division A5] The invention comprises a new compound ZrOGeF 6 . It may be prepared by reacting KGeF 6 with ZrOCl 2 preferably in equimolecular proportions. The KGeF 6 itself may be prepared by reacting GeO 2 with HF and KF and neutralizing with an alkali metal hydroxide, preferably KOH. The new compound ZrOGeF 6 may be incorporated into antioariogenic compositions (see Division A5).
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公开(公告)号：DE3264189D1
公开(公告)日：1985-07-25
申请号：DE3264189
申请日：1982-03-04
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES , REAM RONALD LEE , KLEBER CARL JOSEPH , MOORE DAVID MILTON
Abstract: A chewing gum is disclosed which is for cleaning and imparting a high degree of polish to the teeth; the chewing gum comprises a chewing gum base, at least one non-toxic source of acid in a particular amount, and calcined kaolin particles, the median diameter of which is approximately 2 micrometres or less, and substantially all of the particles being less than approximately 20 micrometres in diameter. Such a chewing gum cleans and imparts a high degree of polish to the teeth without unduly abrading or scratching them, When regularly chewed, such a gum, in addition to cleaning and polishing the dental enamel, can also inhibit the reformation of dental plaque.
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公开(公告)号：GB1260333A
公开(公告)日：1972-01-12
申请号：GB3511471
申请日：1969-03-26
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： MUHLER JOSEPH CHARLES
Abstract: 1,260,333. Dentifrice. INDIANA UNIVERSITY FOUNDATION. 26 March, 1969, No. 35114/71. Divided out of 1,260,322. Heading A5B. A dentifrice composition comprises as a cleaning and polishing agent a mixture of talc, Mg 3 Si 4 O 10 (OH) 2 , and at least a minor amount of tremolite, CaMg 3 (SiO 3 ) 4 , the mixture having a distribution of mean diameter particle sizes in the range of up to 50 microns, together with a carrier suitable for use in the oral cavity. The composition may also contain calcium pyrophosphate; anhydrous calcium hydrogen phosphate; calcium hydrogen phosphate dihydrate; substantially water-impervious, cross-linked, thermosetting, highly polymerised synthetic resins; insoluble sodium metaphosphate; calcium carbonate; condensation products of NH 3 and P 4 O 10 ; fluoride-containing anticariogenic adjuvants; zirconium silicate; and other conventional additives.
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