公开(公告)号：CA2219460A1

公开(公告)日：1996-12-19

申请号：CA2219460

申请日：1996-06-07

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： ROESKE ROGER W

IPC: A61K38/00 ,  A61P5/00 ,  A61P5/04 ,  A61P35/00 ,  C07K7/23 ,  A61K38/09

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

公开(公告)号：AU3130100A

公开(公告)日：2000-07-06

申请号：AU3130100

申请日：2000-05-03

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： ROESKE ROGER W

IPC: A61K38/09 ,  A61P35/00 ,  C07K7/23

公开(公告)号：CA2219460C

公开(公告)日：2009-04-14

申请号：CA2219460

申请日：1996-06-07

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： ROESKE ROGER W

IPC: A61K38/00 ,  C07K7/23 ,  A61K38/08 ,  A61K38/09 ,  A61P5/00 ,  A61P5/04 ,  A61P35/00 ,  C07K7/08

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

公开(公告)号：AU715399B2

公开(公告)日：2000-02-03

申请号：AU6168096

申请日：1996-06-07

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： ROESKE ROGER W

IPC: A61K38/00 ,  A61P5/00 ,  A61P5/04 ,  A61P35/00 ,  C07K7/23 ,  A61K38/09

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

公开(公告)号：WO9640757A3

公开(公告)日：1997-02-20

申请号：PCT/US9609852

申请日：1996-06-07

Applicant: INDIANA UNIVERSITY FOUNDATION ,  ROESKE ROGER W

Inventor： ROESKE ROGER W

IPC: A61K38/00 ,  A61P5/00 ,  A61P5/04 ,  A61P35/00 ,  C07K7/23 ,  A61K38/09

CPC classification number: C07K7/23 ,  A61K38/00 ,  Y10S930/13

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.