公开(公告)号：AT196224T

公开(公告)日：2000-09-15

申请号：AT93915371

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.

公开(公告)号：AU4537893A

公开(公告)日：1994-01-04

申请号：AU4537893

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.

公开(公告)号：CA943775A

公开(公告)日：1974-03-19

申请号：CA132650

申请日：1972-01-18

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： MUHLER JOSEPH C ,  STOOKEY GEORGE K

IPC: A61C15/04

公开(公告)号：AU3816272A

公开(公告)日：1973-07-26

申请号：AU3816272

申请日：1972-01-21

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： MUHLER JOSEPH C ,  STOOKEY GEORGE K

IPC: A61C15/04 ,  A61C15/00

公开(公告)号：CA2223172C

公开(公告)日：2002-11-19

申请号：CA2223172

申请日：1996-05-21

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/175 ,  A23K1/18 ,  A23L1/304 ,  A61K20060101 ,  A61K7/16

Abstract: A chew product useful against the build-up of dental calculus on the teeth o f animals contains an amount of sodium hexametaphosphate effective to reduce t he development of dental calculus. The chew product in one embodiment is prepar ed by soaking the product in an aqueous solution containing from about 0.5 % to about 3.0 % by weight sodium hexametaphosphate. Also disclosed are methods f or preparing the novel chew product and for using the chew product containing sodium hexametaphosphate to reduce and/or prevent the build-up of dental calculus on the teeth of animals.

公开(公告)号：DE69329421T2

公开(公告)日：2001-04-19

申请号：DE69329421

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.

公开(公告)号：DK0644722T3

公开(公告)日：2001-01-22

申请号：DK93915371

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.

公开(公告)号：DE69329421D1

公开(公告)日：2000-10-19

申请号：DE69329421

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.

公开(公告)号：NZ308379A

公开(公告)日：1999-02-25

申请号：NZ30837996

申请日：1996-05-21

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/175 ,  A23K1/18 ,  A23L1/304 ,  A61K20060101 ,  A61K7/16

Abstract: A chew product useful against the build-up of dental calculus on the teeth of animals contains an amount of sodium hexametaphosphate effective to reduce the development of dental calculus. The chew product in one embodiment is prepared by soaking the product in an aqueous solution containing from about 0.5% to about 3.0% by weight sodium hexametaphosphate. Also disclosed are methods for preparing the novel chew product and for using the chew product containing sodium hexametaphosphate to reduce and/or prevent the build-up of dental calculus on the teeth of animals.

公开(公告)号：PT644722E

公开(公告)日：2001-03-30

申请号：PT93915371

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.