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公开(公告)号：AU720359B2
公开(公告)日：2000-06-01
申请号：AU7203396
申请日：1996-09-30
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： WILLIAMS DAVID A
IPC: C12N15/09 , A61K31/00 , A61K35/76 , A61K48/00 , A61P7/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K14/78 , C12N5/0783 , C12N5/0789 , C12N5/10 , C12N15/00 , C12N15/867 , C12R1/92 , A01N43/04 , C12N15/64 , C12N13/00 , C12N5/00 , C12N1/38
Abstract: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
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公开(公告)号：CA2233316C
公开(公告)日：2010-12-14
申请号：CA2233316
申请日：1996-09-30
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： WILLIAMS DAVID A
IPC: C12N5/10 , C12N15/09 , A61K31/00 , A61K35/12 , A61K35/76 , A61K48/00 , A61P7/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K14/78 , C12N5/0783 , C12N5/0789 , C12N15/00 , C12N15/867 , C12R1/92
Abstract: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
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Patent Agency Ranking
公开(公告)号：CA2233316A1
公开(公告)日：1997-04-03
申请号：CA2233316
申请日：1996-09-30
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： WILLIAMS DAVID A
IPC: C12N15/09 , A61K31/00 , A61K35/76 , A61K48/00 , A61P7/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K14/78 , C12N5/0783 , C12N5/0789 , C12N5/10 , C12N15/00 , C12N15/867 , C12R1/92 , A61K35/12 , A61K35/28 , C12N15/86
Abstract: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
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公开(公告)号：CA2142879C
公开(公告)日：2000-10-31
申请号：CA2142879
申请日：1993-09-01
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： WILLIAMS DAVID A , CLARK STEVEN C
Abstract: A method of restoring damaged ar depleted cell populations by treating the patient with cytokines, particularly IL-11 and IL-6.
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公开(公告)号：AU690667B2
公开(公告)日：1998-04-30
申请号：AU2197995
申请日：1995-03-27
Applicant: INDIANA UNIVERSITY FOUNDATION , UNIV NORTHWESTERN
Inventor： WILLIAMS DAVID A , PATEL VIKRAM P
IPC: C12N15/09 , A01K67/027 , A61K35/28 , A61K35/76 , A61K38/00 , A61K38/04 , A61K38/16 , A61K38/22 , A61K38/27 , A61K38/46 , A61K39/395 , A61K47/48 , A61K48/00 , A61P7/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07J1/00 , C07K14/435 , C07K14/47 , C07K14/78 , C07K17/14 , C07K19/00 , C12M3/00 , C12N5/10 , C12N9/78 , C12N15/48 , C12N15/63 , C12N15/867 , A61K38/39 , A61K49/00 , C12N15/00 , C12N15/10 , C12N15/86
Abstract: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. As can be seen in the figure the fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
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公开(公告)号：AU1468797A
公开(公告)日：1997-07-14
申请号：AU1468797
申请日：1996-12-20
Applicant: INDIANA UNIVERSITY FOUNDATION
Inventor： PESCOVITZ ORA H , WILLIAMS DAVID A , KELLEY MARK R
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公开(公告)号：CA2185712A1
公开(公告)日：1995-10-05
申请号：CA2185712
申请日：1995-03-27
Applicant: INDIANA UNIVERSITY FOUNDATION , UNIV NORTHWESTERN
Inventor： WILLIAMS DAVID A , PATEL VIKRAM P
IPC: C12N15/09 , A01K67/027 , A61K35/28 , A61K35/76 , A61K38/00 , A61K38/04 , A61K38/16 , A61K38/22 , A61K38/27 , A61K38/46 , A61K39/395 , A61K47/48 , A61K48/00 , A61P7/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07J1/00 , C07K14/435 , C07K14/47 , C07K14/78 , C07K17/14 , C07K19/00 , C12M3/00 , C12N5/10 , C12N9/78 , C12N15/48 , C12N15/63 , C12N15/867 , C12N15/86 , A61K35/14 , A61K35/50 , C12N15/55
Abstract: A method to increase the efficiency of transduction of hematopoietic and oth er cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. As can be seen in the figu re, the fibronectin and fibronectin fragments significan tly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hem atopoietic stem cells. The invention also provides improved methods for somatic gene th erapy capitalizing on enhanced gene transfer, hematopoie tic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
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