公开(公告)号：US20210292759A1

公开(公告)日：2021-09-23

申请号：US16346251

申请日：2017-11-01

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong KIM ,  Jeong Hun KIM ,  Jihyun LEE ,  Byung Joo LEE

IPC: C12N15/115 ,  A61K31/713 ,  A61K47/61 ,  A61P35/00 ,  A61P27/02

Abstract: The present invention relates to a method for producing dextran polymer-based amplified nucleic acid aptamer nanoconstructs which efficiently and selectively capture a specific target molecule, the method comprising linking a short nucleic acid sequence or a complementary sequence for formation of nanoconstructs and a nucleic acid aptamer sequence for capture of the specific target molecule to a dextran polymer by a chemical reaction, mixing the resulting polymer/nucleic acid substances with each other to form nanostructures, subjecting the nanostructures to rolling circle amplification, thereby forming a nucleic acid aptamer having a repeated structure. The dextran polymer-based amplified nucleic acid aptamer nanoconstructs have the effect of efficiently and selectively capturing a specific target molecule.

公开(公告)号：US20180078620A1

公开(公告)日：2018-03-22

申请号：US15661300

申请日：2017-07-27

Applicant: INSTITUTE FOR BASIC SCIENCE ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

Inventor： Jin-Soo KIM ,  Jeong Hun KIM ,  Sung Wook PARK ,  Kyoungmi KIM

IPC: A61K38/46 ,  C12N15/11

CPC classification number: A61K38/465 ,  A61K48/00 ,  C12N15/102 ,  C12N15/11 ,  C12N15/1136 ,  C12N2310/20 ,  A61K2300/00

Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.