公开(公告)号：US11660312B2

公开(公告)日：2023-05-30

申请号：US16621442

申请日：2018-06-14

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sin-Hyeog Im ,  Ravi Verma ,  Changhon Lee

IPC: A61K31/716 ,  A61K35/745 ,  C12N1/20 ,  A61P37/02 ,  A61P37/08 ,  A61P29/00 ,  C08B37/00 ,  C08L5/00

CPC classification number: A61K31/716 ,  A61K35/745 ,  A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  C08B37/0024 ,  C08L5/00 ,  C12N1/205 ,  A23V2200/324 ,  A23Y2300/25 ,  Y10S424/831

Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing β-1-6-glucan as an effective ingredient, a probiotic strain producing β-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.