公开(公告)号：US20150065720A1

公开(公告)日：2015-03-05

申请号：US14538426

申请日：2014-11-11

Applicant: INTERMUNE, INC.

Inventor： Sabine M. Pyles ,  Michael Cyr ,  Ramachandran Radhakrishnan

IPC: C07D213/64

CPC classification number: C07D213/64 ,  A61K31/4412

Abstract: A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.

Abstract translation: 公开了一种从小于约0.15％（重量）二溴苯的溴苯合成吡非尼酮的方法。 还公开了在不使用乙酸乙酯或正丁醇的情况下合成吡非尼酮的方法，以及具有受控含量的乙酸乙酯，正丁醇，二（5-甲基-2-吡啶酮）苯和具有特定保留时间的其它杂质的吡非尼酮。 还公开了包括所公开的吡非尼酮的配制剂型。

公开(公告)号：US20130345430A1

公开(公告)日：2013-12-26

申请号：US13947643

申请日：2013-07-22

Applicant: INTERMUNE, INC.

Inventor： Sabine M. Pyles ,  Michael Cyr ,  Ramachandran Radhakrishnan

IPC: C07D213/64

CPC classification number: C07D213/64 ,  A61K31/4412

Abstract: A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.

公开(公告)号：US20150368200A1

公开(公告)日：2015-12-24

申请号：US14830999

申请日：2015-08-20

Applicant: INTERMUNE, INC.

Inventor： Sabine M. Pyles ,  Michael Cyr ,  Ramachandran Radhakrishnan

IPC: C07D213/64

CPC classification number: C07D213/64 ,  A61K31/4412

Abstract: A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.

公开(公告)号：US20140221660A1

公开(公告)日：2014-08-07

申请号：US14247357

申请日：2014-04-08

Applicant: INTERMUNE, INC.

Inventor： Sabine M. Pyles ,  Michael Cyr ,  Ramachandran Radhakrishnan

IPC: C07D213/64

CPC classification number: C07D213/64 ,  A61K31/4412

Abstract: A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.

Abstract translation: 公开了一种从小于约0.15％（重量）二溴苯的溴苯合成吡非尼酮的方法。 还公开了在不使用乙酸乙酯或正丁醇的情况下合成吡非尼酮的方法，以及具有受控含量的乙酸乙酯，正丁醇，二（5-甲基-2-吡啶酮）苯和具有特定保留时间的其它杂质的吡非尼酮。 还公开了包括所公开的吡非尼酮的配制剂型。