公开(公告)号：WO2021170786A1

公开(公告)日：2021-09-02

申请号：PCT/EP2021/054801

申请日：2021-02-26

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： YAHYANEJAD, Sanaz ,  TELFORD, Bryony ,  VAN DEN BOSCH, Marion ,  ALEMDEHY, Mir Farshid ,  DE GUNST, Matheus Maria ,  VAN PINXTEREN, Laurens Adrianus Hendricus ,  SCHAAPVELD, Roeland Quirinus Jozef ,  JANICOT, Michel

IPC: C12N15/113

Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a CRT agonist, promoting the cell surface expression of CRT. This allows the advantageous treatment of cancers without or with low surface expression of CRT. The invention further relates to compositions comprising the miRNA for use in such treatment.

公开(公告)号：WO2021028081A1

公开(公告)日：2021-02-18

申请号：PCT/EP2020/055965

申请日：2020-03-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： YAHYANEJAD, Sanaz ,  TELFORD, Bryony ,  VAN DEN BOSCH, Marion ,  ALEMDEHY, Mir Farshid ,  DE GUNST, Matheus Maria ,  VAN PINXTEREN, Laurens Adrianus Hendricus ,  SCHAAPVELD, Roeland Quirinus Jozef ,  JANICOT, Michel

IPC: C12N15/113

Abstract: The invention relates to the use ofmiRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a PTEN agonist. This allows the advantageous treatment of PTEN- deficient cancers. The invention further relates to compositions comprising the miRNA for use as a PTEN agonist.

公开(公告)号：EP4110917A1

公开(公告)日：2023-01-04

申请号：EP21706991.3

申请日：2021-02-26

Applicant: InteRNA Technologies B.V.

Inventor： YAHYANEJAD, Sanaz ,  TELFORD, Bryony ,  VAN DEN BOSCH, Marion ,  ALEMDEHY, Mir Farshid ,  DE GUNST, Matheus Maria ,  VAN PINXTEREN, Laurens Adrianus Hendricus ,  SCHAAPVELD, Roeland Quirinus Jozef ,  JANICOT, Michel

IPC: C12N15/113