公开(公告)号：WO2019006257A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/040218

申请日：2018-06-29

Applicant: INVISTA NORTH AMERICA .S.A.R.L.

Inventor： FOSTER, Alexander, Brett ,  PATTENDEN, Leonard, Keith ,  RAND, Jonathan, David ,  ROBERTS, Ana Teresa Dos Santos Brito, Mendes ,  SHAW, Andrew ,  TAYLOR, Mark, Paul

IPC: C12N1/30 ,  C12N9/88 ,  C12P5/00

CPC classification number: C12P5/007 ,  C12N1/20 ,  C12N9/1022 ,  C12N9/88 ,  C12Y202/01007 ,  C12Y402/03027

Abstract: Disclosed herein are methods, compositions, and hosts for synthesizing hydrocarbons, and derivatives thereof, comprising one or more isoprene units as well as salts or derivatives thereof. An aspect of the present invention thus relates to a method for biosynthesizing hydrocarbons in a recombinant host selected from non-pathogenic members of the genera Ralstonia, Wausteria, Cupriavidus, Alcaligenes, Burkholderia, or Pandoraea. Said recombinant host comprises an exogenous nucleic acid sequence encoding a polypeptide having an enzyme activity selected from 1-deoxy-D-xylulose-5-phosphate synthase (DXS) activity (EC 2.2.1.7) and isoprene synthase enzyme activity (EC 4.2.3.27).

公开(公告)号：WO2018064105A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/053607

申请日：2017-09-27

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： CARTMAN, Stephen, Thomas ,  FOSTER, Alexander, Brett ,  MENDES, Ana Teresa, De Santos Brito ,  TAYLOR, Mark, Paul

IPC: C12P5/02 ,  C12R1/01

CPC classification number: C12P5/007 ,  C07C11/12 ,  C08F136/08 ,  C12N9/88 ,  C12N9/90 ,  C12N15/74 ,  C12N2330/30 ,  C12P5/026 ,  C12R1/01 ,  C12Y402/03027 ,  C12Y503/03002 ,  Y02E50/343

Abstract: Methods and compositions for synthesizing dienes and derivative thereof, such as isoprene, in Cupriavidus necator are provided.

Abstract translation: 提供了用于在Cupriavidus necator中合成二烯及其衍生物如异戊二烯的方法和组合物。