公开(公告)号：US20170009263A1

公开(公告)日：2017-01-12

申请号：US15204008

申请日：2016-07-07

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Van Eck CONRADIE ,  Mariusz Stanislaw KAMIONKA

IPC: C12P7/18 ,  C07C31/20 ,  C12N9/10 ,  C12N9/88 ,  C12N9/02

CPC classification number: C12P7/18 ,  C07C31/207 ,  C12N9/0008 ,  C12N9/13 ,  C12N9/88 ,  C12P7/16 ,  C12Y102/0101 ,  C12Y208/03 ,  C12Y401/01005 ,  Y02E50/10

Abstract: This application describes non-naturally occurring host cells for enhanced 1,3-butanediol (1,3-BDO) production, methods for producing 1,3-BDO using such non-naturally occurring host cells, and 1,3-BDO products produced by such non-naturally occurring host cells and methods.

Abstract translation: 本申请描述了用于增强的1,3-丁二醇（1,3-BDO）生产的非天然存在的宿主细胞，使用这种非天然存在的宿主细胞产生1,3-BDO的方法和产生的1,3-BDO产物 通过这种非天然存在的宿主细胞和方法。

公开(公告)号：US20180273987A1

公开(公告)日：2018-09-27

申请号：US15903744

申请日：2018-02-23

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Nadia Fatma KADI ,  Mariusz Stanislaw KAMIONKA ,  Alexander Brett FOSTER ,  Alex Van Eck CONRADIE ,  Adriana Leonora BOTES

IPC: C12P7/62 ,  C12N9/02 ,  C07C69/42 ,  C12N9/10 ,  C12N9/16 ,  C12N15/52 ,  C12P13/00 ,  C12P7/42 ,  C12P7/44 ,  C07C229/08 ,  C12N9/18

CPC classification number: C12P7/62 ,  C07C69/42 ,  C07C229/08 ,  C12N9/0008 ,  C12N9/1007 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/18 ,  C12N15/52 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12Y102/99006 ,  C12Y201/01197 ,  C12Y206/01018 ,  C12Y206/01038 ,  C12Y301/01085

Abstract: This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.

公开(公告)号：US20170240936A1

公开(公告)日：2017-08-24

申请号：US15436315

申请日：2017-02-17

Applicant: INVISTA North America S.a.r.l.

Inventor： Gary SMITH ,  Alex Van Eck CONRADIE ,  Gregory S. KIRBY ,  Paul S. PEARLMAN

IPC: C12P13/00 ,  C12P7/62 ,  C25B1/04 ,  C12M1/00 ,  C12M1/34 ,  C12P5/00 ,  C12P7/06 ,  C12N1/20

CPC classification number: C12P13/001 ,  C12M29/00 ,  C12M41/00 ,  C12N1/20 ,  C12P5/00 ,  C12P5/007 ,  C12P5/02 ,  C12P7/065 ,  C12P7/24 ,  C12P7/625 ,  C12P13/00 ,  C25B1/04 ,  F01D15/10 ,  F01K7/16 ,  F01K11/02 ,  F05D2220/31 ,  Y02E50/17 ,  Y02E50/343 ,  Y02E60/366

Abstract: The present disclosure describes biocatalytic processes for producing a product, comprising providing an aqueous stream (AS) comprising at least one fermentable substrate and a gaseous stream (GS) comprising at least one of CO2/H2, H2, methane, and/or CO to a fermentation zone, wherein the GS and AS stream are optionally contacted and/or mixed; the fermentation zone comprising at least one organism capable of metabolizing an AS substrate and a GS substrate, wherein the fermentation operates at conditions to mixotrophically metabolize at least one gaseous substrate in the GS and at least one substrate in the AS, producing the product. The present disclosure also describes compositions comprising an AS, a GS, and an organism, wherein the organism or an equivalent or engineered equivalent thereof is a methanotroph or a hydrogen-metabolizing or CO-metabolizing chemolithotrophic organism, and wherein the organism is capable of mixotrophic metabolism of at least one gaseous substrate in the GS and at least one substrate in the AS. The present disclosure also describes a process wherein said fermentation operates at conditions to mixotrophically metabolize at least H2 in the gaseous stream and glycerol and lactic acid in the aqueous stream. The present disclosure also describes a system for producing a fermentation or bio-derived product.

公开(公告)号：US20190300913A1

公开(公告)日：2019-10-03

申请号：US16376721

申请日：2019-04-05

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Van Eck CONRADIE ,  Adriana Leonora BOTES

IPC: C12P5/02

Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as, inter alia, a decarboxylating thioesterase, cytochrome P450, or dehydratases for the final enzymatic step.

公开(公告)号：US20190203241A1

公开(公告)日：2019-07-04

申请号：US16299698

申请日：2019-03-12

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Van Eck CONRADIE ,  Adriana Leonora BOTES

IPC: C12P19/32 ,  C12P7/40 ,  C12N9/10 ,  C12P7/26

CPC classification number: C12P19/32 ,  C12N9/1029 ,  C12P7/26 ,  C12P7/40 ,  C12Y203/01016

Abstract: This document describes biochemical pathways that include the production of 3-oxopent-4-enoyl-CoA by condensation of acryloyl-CoA and acetyl-CoA using a β-ketothiolase with a SER-HIS-HIS catalytic triad. These pathways described herein rely on enzymes such as, inter alia, dehydrogenases, dehydratases and β-ketothiolases.

公开(公告)号：US20190017076A1

公开(公告)日：2019-01-17

申请号：US15932217

申请日：2016-08-16

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Van Eck CONRADIE

IPC: C12P5/00 ,  C07C11/18 ,  C08F136/08 ,  C12P19/32 ,  C12P7/42

Abstract: This application describes methods, including non-naturally occurring methods, for biosynthesizing 3-hydroxy-3-methylglutaryl-coA and intermediates thereof, as well as non-naturally occurring hosts for producing 3-hydroxy-3-methylglutaryl-coA. This application also describes methods, including non-naturally occurring methods, for biosynthesizing isoprene and intermediates thereof, as well as non-naturally occurring hosts for producing isoprene.

公开(公告)号：US20190093130A1

公开(公告)日：2019-03-28

申请号：US16144035

申请日：2018-09-27

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Paul S. PEARLMAN ,  Alex Van Eck CONRADIE ,  Gary SMITH

IPC: C12P5/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/00 ,  C08F36/08

Abstract: Methods for biosynthesising hydrocarbons from a gaseous substrate in non-naturally occurring acetogens as well as non-naturally occurring acetogens for production of hydrocarbons are provided.

公开(公告)号：US20180291401A1

公开(公告)日：2018-10-11

申请号：US15932189

申请日：2016-08-16

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Van Eck CONRADIE

IPC: C12P5/00 ,  C12P7/42 ,  C12N15/52 ,  C12N9/04

Abstract: This application describes methods, including non-naturally occurring methods, for biosynthesizing unsaturated pentahydrocarbons, such as isoprene and intermediates thereof, via the mevalonate pathway, as well as non-naturally occurring hosts for producing isoprene.