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公开(公告)号：US20170159082A1
公开(公告)日：2017-06-08
申请号：US15368419
申请日：2016-12-02
Applicant: INVISTA North America S.a.r.l.
CPC classification number: C12P7/26 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/13 , C12N9/88 , C12P11/00 , C12P13/00 , C12P19/32 , C12P21/00 , C12Y101/01035 , C12Y101/011 , C12Y103/01009 , C12Y103/01038 , C12Y203/01016 , C12Y203/01041 , C12Y203/01174 , C12Y203/01179 , C12Y203/0118 , C12Y208/03 , C12Y402/01017
Abstract: This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form either a 5-amino-3-oxopentanoyl-[ACP] or 5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or the corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or the corresponding salts thereof.
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公开(公告)号：US20200157582A1
公开(公告)日：2020-05-21
申请号：US16685290
申请日：2019-11-15
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander STEINBÜCHEL , Jessica EGGERS , Alexander Brett FOSTER , Jonathan KENNEDY
Abstract: Nonnaturally occurring organisms exhibiting improved carbon utilization and methods for production and use of these nonnaturally occurring organisms in chemical production from carbon containing feedstocks are provided.
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3.发明申请公开(公告)号：US20190233851A1
公开(公告)日：2019-08-01
申请号：US16264782
申请日：2019-02-01
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Jonathan KENNEDY , Alexander Brett FOSTER
CPC classification number: C12P7/42 , C12N9/001 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12R1/01 , C12Y103/01039 , C12Y301/02007 , C12Y401/99005 , C12Y602/01003
Abstract: Methods and materials for the production of compounds involved in fatty acid metabolism, and/or derivatives thereof and/or compounds related thereto are provided. Also provided are products produced in accordance with the methods and materials of the present invention.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20180023103A1
公开(公告)日：2018-01-25
申请号：US15659505
申请日：2017-07-25
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander Brett FOSTER , Stephen Thomas CARTMAN , Jonathan KENNEDY , William Joseph SIMMONS
IPC: C12P7/62 , C07C59/147 , C07C47/19 , C07C223/02 , C07C225/06 , C07C47/12 , C07C55/16 , C12P13/00 , C12P7/44 , C12P7/18 , C12N9/88 , C12N9/04 , C12N9/10 , C12N9/16 , C07C229/08
Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.
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5.发明申请公开(公告)号：US20180023102A1
公开(公告)日：2018-01-25
申请号：US15658958
申请日：2017-07-25
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander Brett FOSTER , Stephen Thomas CARTMAN , Jonathan KENNEDY
CPC classification number: C12P7/44 , C12N15/52 , C12P7/24 , C12P7/62 , C12P13/001 , C12P13/005 , C12Y102/01 , C12Y102/99006 , C12Y206/01 , C12Y206/01018 , C12Y301/02
Abstract: Disclosed are methods for regulating biosynthesis of at least one of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, 7-aminohelptanol and 1,7-heptanediol (C7 building blocks) using a pathway having a pimeloyl-ACP intermediate, the method including the step of downregulating the activity of BioF. Also disclosed are recombinant hosts by fermentation in which the above methods are performed. Further disclosed are recombinant hosts for producing pimeloyl-ACP, the recombinant host including a deletion of a bioF gene.
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公开(公告)号：US20190337995A1
公开(公告)日：2019-11-07
申请号：US16398365
申请日：2019-04-30
Applicant: INVISTA NORTH AMERICA S.A.R.L.
Inventor： Alexander Brett FOSTER , Ana Teresa dos Santos Brito Mendes ROBERTS , Arghya BARMAN , Jonathan KENNEDY
IPC: C07K14/195 , C12P7/56 , C12P7/42 , C12P7/54 , C12P7/18
Abstract: Methods for increasing carbon-based chemical product yield in an organism by increasing carbon uptake and/or altering a pathway to or from an overflow metabolite in the organism, nonnaturally occurring organisms having increased carbon-based chemical product yield with increased carbon uptake and/or an altered pathway to or from an overflow metabolite, and methods for producing a carbon-based chemical product with these organisms are provided.
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公开(公告)号：US20180066296A9
公开(公告)日：2018-03-08
申请号：US15368092
申请日：2016-12-02
Applicant: INVISTA North America S.a.r.l.
CPC classification number: C12P19/32 , C08G69/02 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/13 , C12P7/18 , C12P7/42 , C12P7/48 , C12P11/00 , C12P13/00 , C12P13/001 , C12P21/00 , C12Y102/99006 , C12Y203/01 , C12Y203/01016 , C12Y203/01041 , C12Y203/01174 , C12Y203/01179 , C12Y203/0118 , C12Y206/01018 , C12Y208/03
Abstract: This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form an N-acetyl-5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or corresponding salts thereof.
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公开(公告)号：US20170159092A1
公开(公告)日：2017-06-08
申请号：US15368092
申请日：2016-12-02
Applicant: INVISTA North America S.a.r.l.
CPC classification number: C12P19/32 , C08G69/02 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/13 , C12P7/18 , C12P7/42 , C12P7/48 , C12P11/00 , C12P13/00 , C12P13/001 , C12P21/00 , C12Y102/99006 , C12Y203/01 , C12Y203/01016 , C12Y203/01041 , C12Y203/01174 , C12Y203/01179 , C12Y203/0118 , C12Y206/01018 , C12Y208/03
Abstract: This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form an N-acetyl-5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or corresponding salts thereof.
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