公开(公告)号：US20190300871A1

公开(公告)日：2019-10-03

申请号：US16237871

申请日：2019-01-02

Applicant: INVISTA North America S.à.r.l.

Inventor： Eric ALTHOFF ,  Nadia KADI ,  Mihai AZOITEI ,  Yih-En A. BAN ,  Daniela GRABS-RÖTHLISBERGER ,  Alexander PISARCHIK ,  Alexandre ZANGHELLINI ,  Adriana L. BOTES

IPC: C12N9/88 ,  A61K38/00 ,  C12P5/00 ,  C07C11/21 ,  C12P5/02 ,  C08F136/06 ,  C07C11/167 ,  C07C11/18 ,  G01N33/573 ,  C07K16/40 ,  C08F36/06 ,  C08F36/08 ,  C08F36/22 ,  C08F136/08

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.