公开(公告)号：US10519433B2

公开(公告)日：2019-12-31

申请号：US15056026

申请日：2016-02-29

Applicant: INVISTA North America S.a.r.l.

Inventor： Nadia Kadi ,  Adriana L. Botes ,  Mihai Luchian Azoitei ,  Yih-En A. Ban ,  Daniela Grabs-Röthlisberger ,  Alexander Pisarchik ,  Alexandre Zanghellini ,  Eric Althoff

IPC: C12N9/88 ,  C08F136/08 ,  C08F136/06 ,  C08F36/22 ,  C07C11/21 ,  C07C11/18 ,  C07C11/167 ,  G01N33/573 ,  C08F36/06 ,  C07K16/40 ,  C08F36/08 ,  C12P5/02 ,  C12P5/00 ,  A61K38/00

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

公开(公告)号：US10214736B2

公开(公告)日：2019-02-26

申请号：US15593395

申请日：2017-05-12

Applicant: INVISTA North America S.A.R.L.

Inventor： Eric Althoff ,  Nadia Kadi ,  Mihai Luchian Azoitei ,  Yih-En A. Ban ,  Daniela Grabs-Röthlisberger ,  Alexander Pisarchik ,  Alexandre Zanghellini ,  Adriana L. Botes

IPC: C12N9/88 ,  A61K38/00 ,  C12P5/00 ,  C12P5/02 ,  C07C11/167 ,  C07C11/18 ,  C07C11/21 ,  C07K16/40 ,  C08F36/06 ,  C08F36/08 ,  C08F36/22 ,  G01N33/573 ,  C08F136/06 ,  C08F136/08

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

公开(公告)号：US20160251645A1

公开(公告)日：2016-09-01

申请号：US15056026

申请日：2016-02-29

Applicant: INVISTA North America S.a.r.l.

Inventor： ADRIANA L. BOTES ,  Nadia Kadi ,  Mihai Luchian Azoitei ,  Yih-En A. Ban ,  Daniela Grabs-Röthlisberger ,  Alexander Pisarchik ,  Alexandre Zanghellini ,  Eric Althoff

IPC: C12N9/88 ,  C07K16/40 ,  G01N33/573 ,  C12P5/00 ,  C08F36/06 ,  C07C11/18 ,  C07C11/21 ,  C08F36/08 ,  C08F36/22 ,  C12P5/02 ,  C07C11/167

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

公开(公告)号：US09220742B1

公开(公告)日：2015-12-29

申请号：US14800961

申请日：2015-07-16

Applicant: INVISTA North America S.a.r.l.

Inventor： Adriana Botes ,  Nadia Kadi ,  Mihai Luchian Azoitei ,  Yih-En A Ban ,  Daniela Grabs-Röthlisberger ,  Alexander Pisarchik ,  Alexandre Zanghellini ,  Eric Althoff

IPC: A61K38/51 ,  C12N9/90 ,  A61K38/00

CPC classification number: C12N9/88 ,  A61K38/00 ,  C07C11/167 ,  C07C11/18 ,  C07C11/21 ,  C07K16/40 ,  C07K2299/00 ,  C08F36/06 ,  C08F36/08 ,  C08F36/22 ,  C08F136/06 ,  C08F136/08 ,  C12P5/007 ,  C12P5/026 ,  C12Y402/01053 ,  C12Y402/01095 ,  C12Y402/01127 ,  C12Y402/01131 ,  G01N33/573

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

Abstract translation: 本公开提供具有3-丁烯-2-醇脱水酶活性的新型多肽，在3-甲基-3-丁烯-2-醇转化为异戊二烯时具有催化活性的多肽，以及这些多肽之一的晶体结构数据。 还提供了制备和使用多肽及其相关晶体结构数据的方法。