公开(公告)号：WO2015195678A1

公开(公告)日：2015-12-23

申请号：PCT/US2015/036050

申请日：2015-06-16

Applicant: INVISTA Technologies S.à r.l.

Inventor： BOTES, Adriana Leonora ,  CONRADIE, Alex Van Eck ,  HADDOUCHE, Ramdane

IPC: C12P7/42

CPC classification number: C12P13/001 ,  C07C47/02 ,  C07C47/12 ,  C07C59/01 ,  C07C59/325 ,  C07C223/02 ,  C08G63/06 ,  C12N9/0008 ,  C12N9/0077 ,  C12N9/1007 ,  C12N9/1096 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y102/99006 ,  C12Y114/15001 ,  C12Y114/15003 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082

Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase , an alcohol O-acetyltransferase , and a monooxygenase , as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.

Abstract translation: 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶来生产7-羟基庚酸甲酯和庚酸庚酯的生物化学途径，以及表达一种或多种这样的 外源酶。 7-羟基庚酸甲酯和庚酸庚酯可以酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。

公开(公告)号：EP3224365A1

公开(公告)日：2017-10-04

申请号：EP15805044.3

申请日：2015-11-20

Applicant: Invista Technologies S.à r.l.

Inventor： BOTES, Adriana Leonora ,  CONRADIE, Alex Van Eck ,  HADDOUCHE, Ramdane

IPC: C12P7/42 ,  C12P7/44 ,  C12P7/64 ,  C12N9/02

CPC classification number: C12N9/0071 ,  C07C47/12 ,  C07C47/19 ,  C07C49/185 ,  C07C223/02 ,  C07C229/08 ,  C07C229/12 ,  C12N9/0008 ,  C12N9/0073 ,  C12N9/18 ,  C12N9/20 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12Y114/13 ,  C12Y114/14001 ,  C12Y301/01001 ,  C12Y301/01003

Abstract: This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a
monooxygenase to form a 7-hydroxyoctanoate intermediate, which can be converted to 6-hydroxyhexanoate using a polypeptide having
monooxygenase ,
secondary alcohol dehydrogenase , or
esterase activity. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.

Abstract translation: 该文献描述了使用单加氧酶生成6-羟基己酸以形成7-羟基辛酸酯中间体的生物化学途径，其可以使用具有单加氧酶，仲醇脱氢酶或酯酶活性的多肽转化成6-羟基己酸酯。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。 该文件还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。

公开(公告)号：EP3155110A1

公开(公告)日：2017-04-19

申请号：EP15731806.4

申请日：2015-06-16

Applicant: Invista Technologies S.à r.l.

Inventor： BOTES, Adriana Leonora ,  CONRADIE, Alex Van Eck ,  HADDOUCHE, Ramdane

IPC: C12P7/42

CPC classification number: C12P13/001 ,  C07C47/02 ,  C07C47/12 ,  C07C59/01 ,  C07C59/325 ,  C07C223/02 ,  C08G63/06 ,  C12N9/0008 ,  C12N9/0077 ,  C12N9/1007 ,  C12N9/1096 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y102/99006 ,  C12Y114/15001 ,  C12Y114/15003 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082

Abstract: This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.