公开(公告)号：WO2007064397A2

公开(公告)日：2007-06-07

申请号：PCT/US2006/038194

申请日：2006-09-28

Applicant: ISP INVESTMENTS INC. ,  MINGTAI CHEMICAL CO., LTD. ,  HALDAR, Rama ,  RAY, Dipan, B. ,  BEE, Timothy, G. ,  ETIENNE, Sidney ,  CHENG, Su-Jane

Inventor： HALDAR, Rama ,  RAY, Dipan, B. ,  BEE, Timothy, G. ,  ETIENNE, Sidney ,  CHENG, Su-Jane

IPC: A61K9/20 ,  B27N3/00

CPC classification number: A61K9/2095 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077

Abstract: Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1 -30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.

Abstract translation: 药物，营养或维生素活性化合物或组合物的片剂，例如片剂。 （a）乙烯基吡咯烷酮（VP）和乙酸乙烯酯（VA）的共聚物和（b）微晶纤维素（MCC）的协同粘合剂组合物通过直接压制制备不良可压缩药物， （a）：（b）的比例为1-30：99-70，其被喷雾干燥以提供用于这种活性物质的易于压缩的赋形剂粘合剂粉末。 本文获得的片剂在可接受的压缩力下具有有利的硬度和脆性。

公开(公告)号：WO2004041102A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/032404

申请日：2003-10-14

Applicant: ISP INVESTMENTS INC.

Inventor： PROSISE, William, E. ,  BEE, Timothy, G. ,  DRZEWINSKI, Michael, A.

IPC: A61C

CPC classification number: A61K8/0208 ,  A61C19/066 ,  A61K8/22 ,  A61K8/345 ,  A61K8/8176 ,  A61Q11/00

Abstract: A delivery system for delivering a tooth whitening substance to a surface of an oral cavity, comprising a film of flexible malleable polymer material having a tooth whitening substance as an integral component of said film, thus providing an active on said oral surface when said film is adhered to the oral surface, said film having a dissolution rate in the aqueous medium of the oral cavity such that the tooth whitening substance can release its active upon said oral surface to act effectively thereon within a predetermined period of time, said film being disintegrable thereafter after effecting its tooth whitening action.

Abstract translation: 一种用于将牙齿增白物质递送至口腔表面的递送系统，该递送系统包括具有牙齿增白物质作为所述薄膜的整体组分的柔性可延展聚合物材料的薄膜，从而提供活性成分 当所述膜粘附到口腔表面时，所述膜在口腔的水性介质中具有溶解速率，使得牙齿增白物质可以在所述口腔表面上释放其活性物质，以在预定时间段内有效地作用于其上 在影响牙齿美白作用之后，所述胶片可以分解。

公开(公告)号：EP1560536A2

公开(公告)日：2005-08-10

申请号：EP03777577.2

申请日：2003-10-14

Applicant: ISP INVESTMENTS INC.

Inventor： PROSISE, William, E. ,  BEE, Timothy, G. ,  DRZEWINSKI, Michael, A.

IPC: A61C1/00

CPC classification number: A61K8/0208 ,  A61C19/066 ,  A61K8/22 ,  A61K8/345 ,  A61K8/8176 ,  A61Q11/00

Abstract: A delivery system for delivering a tooth whitening substance to a surface of an oral cavity, comprising a film of flexible malleable polymer material having a tooth whitening substance as an integral component of said film, thus providing an active on said oral surface when said film is adhered to the oral surface, said film having a dissolution rate in the aqueous medium of the oral cavity such that the tooth whitening substance can release its active upon said oral surface to act effectively thereon within a predetermined period of time, said film being disintegrable thereafter after effecting its tooth whitening action.