公开(公告)号：US20010046476A1

公开(公告)日：2001-11-29

申请号：US09921186

申请日：2001-08-02

Applicant: ISP INVESTMENTS INC.

Inventor： Krystyna Plochocka

IPC: A61K007/16

CPC classification number: C08F8/00 ,  A61K8/8164 ,  A61K8/8182 ,  A61K2800/57 ,  A61Q11/00 ,  C08F222/12

Abstract: A polymer useful in oral care compositions which has a reactive group covalently bonded to a bactericide, flavorant and/or essential oil compound, said bond being hydrolyzable in aqueous solution to slowly release said compound into said composition.

Abstract translation: 可用于口腔护理组合物中的聚合物，其具有与杀菌剂，调味剂和/或精油化合物共价结合的反应性基团，所述键可在水溶液中水解，以将所述化合物缓慢释放到所述组合物中。

公开(公告)号：US20040253188A1

公开(公告)日：2004-12-16

申请号：US10461796

申请日：2003-06-13

Applicant: ISP INVESTMENTS INC.

Inventor： Krystyna Plochocka

IPC: A61K007/16

CPC classification number: A61Q11/00 ,  A61K8/0208 ,  A61K8/8164 ,  A61K2800/57

Abstract: A polymer for use in an oral care composition which includes a monomer repeat unit containing an active material covalently bonded to a hydrolyzable side group of said monomer unit, and a spacer group positioned between the main chain of said polymer and said hydrolyzable side group, said polymer having a predetermined rapid rate of aqueous hydrolysis to release said active material therefrom.

Abstract translation: 一种用于口腔护理组合物的聚合物，其包含含有共价键合到所述单体单元的可水解侧基的活性物质的单体重复单元和位于所述聚合物的主链和所述可水解侧基之间的间隔基，所述聚合物 聚合物具有预定的水解水解速率以从其中释放所述活性物质。

公开(公告)号：US20020111394A1

公开(公告)日：2002-08-15

申请号：US09735562

申请日：2000-12-13

Applicant: ISP INVESTMENTS INC.

Inventor： William E. Prosise ,  Krystyna Plochocka

IPC: C08K003/00 ,  A61K006/08

CPC classification number: A61K6/0026 ,  A61K6/0008 ,  C08F8/44 ,  C08F222/02 ,  C08F216/18 ,  C08L35/08 ,  C08L33/08 ,  C08L27/00 ,  C08L1/02 ,  C08L33/10

Abstract: This invention relates to a denture adhesive powder composition having extended holding power and markedly increased adhesion properties which comprises an adhesive amount of an inorganic salt of a C1 to C4 alkyl vinyl ether/maleic acid polymer wherein 50-90% of the acid moieties of the polymer are in the form of a metal salt and 50-1000 ppm of a mixture containing 30-70 wt. % neutralized or unneutralized ethylenediamine- tetraacetic acid (EDTA) and 70-30 wt. % of an organic, hydroxylated antioxidant and free radical scavenger, said composition in solution with water having a pH above 5.5 and to the method for the preparation of said composition.

Abstract translation: 本发明涉及具有延长的保持力和明显增加的粘附性的义齿粘合剂粉末组合物，其包含粘合剂量的C1至C4烷基乙烯基醚/马来酸聚合物的无机盐，其中50-90％的酸部分 聚合物是金属盐的形式，和50-1000ppm的含有30-70wt。 ％中和或未中和乙二胺四乙酸（EDTA）和70-30重量％ ％的有机羟基化抗氧化剂和自由基清除剂，所述组合物在溶液中的水的pH值高于5.5，以及制备所述组合物的方法。

公开(公告)号：US20030236349A1

公开(公告)日：2003-12-25

申请号：US10397900

申请日：2003-03-26

Applicant: ISP INVESTMENTS INC.

Inventor： Krystyna Plochocka ,  Jeffrey A. Lynn

IPC: C08F002/00 ,  C08F016/06

CPC classification number: C08L73/02 ,  A61L15/585 ,  C08F261/04 ,  C08F261/06 ,  C08F265/02 ,  C08F283/00 ,  C08L71/02 ,  C08L2205/05 ,  C08L35/00 ,  C08L2666/04

Abstract: What is described is a polymeric hydrogel of a polymeric anhydride or acid, e.g. maleic anhydride or maleic acid polymer, or copolymer thereof, crosslinked with a crosslinking agent containing at least 2 crosslinkable groups, particularly, nullOH or nullNH2, or both. The reaction product is a crosslinked polymeric ester or amide/imide, or both, suitably having a mole ratio of nullOH, or nullNH2, to nullCOOH, of 1:10 to 10:1, preferably 2:10 to 7:1. The hydrogel is particularly swellable in water, e.g. >100% in 1 hour in aqueous media; and forms a thin, tacky layer on a substrate, which property is useful in bioadhesive products.

Abstract translation: 所描述的是聚合物酐或酸的聚合物水凝胶，例如聚合物。 马来酸酐或马来酸聚合物或其共聚物与含有至少2个可交联基团，特别是-OH或-NH 2或两者的交联剂交联。 反应产物是交联的聚合酯或酰胺/酰亚胺或两者，适当地具有1:10至10:1，优选2:10至7:1的-OH或-NH 2与-COOH的摩尔比 。 水凝胶在水中特别溶胀，例如 在水介质中1小时内> 100％ 并且在基底上形成薄的粘性层，该性质在生物粘附产品中是有用的。

公开(公告)号：US20010053829A1

公开(公告)日：2001-12-20

申请号：US09861044

申请日：2001-05-18

Applicant: ISP INVESTMENTS INC.

Inventor： Russell Biss ,  Jeffrey Cohen ,  John Zamora ,  Krystyna Plochocka ,  Jeffrey A. Lynn

IPC: C08F002/00

CPC classification number: C08F222/06 ,  C08F2/02 ,  C08F216/18 ,  Y02P20/582

Abstract: A continuous, solvent-free process for obtaining solvent-free, fine white powders of high molecular weight alternating copolymers of maleic anhydride and a C1-C4 alkyl vinyl ether, without odor or taste, having the molecular structure (A-B)n, where A is maleic anhydride, B is an alkyl vinyl ether and n is an integer indicative of the molecular weight of the copolymer, which comprises feeding alkyl vinyl ether as reactant and solvent in excess over the desired 1:1 mole ratio of A:B in the copolymer, molten maleic anhydride and a free radical initiator, continuously at predetermined feeding rates into a reactor heated at a reaction temperature of about 50null to 100null C., charging the reactor and withdrawing reaction product, residual alkyl vinyl ether and initiator from the reactor at the same rate as the feed rate of reactants into the reactor simultaneously thereby maintaining a constant volume in the reactor, stripping residual alkyl vinyl ether from the reaction product, drying the copolymer obtained of any remaining traces of alkyl vinyl ether, and recycling recovered alkyl vinyl ether back into reactor as reactant and solvent.

Abstract translation: 一种连续，无溶剂的方法，用于获得具有分子结构（AB）n的不含气味或味道的马来酸酐和C1-C4烷基乙烯基醚的高分子量交替共聚物的无溶剂的细白色粉末，其中A 是马来酸酐，B是烷基乙烯基醚，n是表示共聚物的分子量的整数，其包括将烷基乙烯基醚作为反应物和过量的丙烯进料到所需的1:1摩尔比的A:B中 共聚物，熔融马来酸酐和自由基引发剂，以预定的进料速率连续加入到在约50℃至100℃的反应温度下加热的反应器中，将反应器和残留的烷基乙烯基醚和引发剂从 反应器以与反应物进入反应器的进料速率相同的速率同时由此在反应器中保持恒定体积，从反应产物中汽提残余的烷基乙烯基醚，干燥该共聚物 获得任何剩余痕量的烷基乙烯基醚的聚合物，并将回收的烷基乙烯基醚回收到反应器中作为反应物和溶剂。