公开(公告)号：WO2022228967A1

公开(公告)日：2022-11-03

申请号：PCT/EP2022/060428

申请日：2022-04-20

Applicant: IMEC VZW

Inventor： TAHER, Ahmed ,  JONES, Benjamin ,  ROTH, Sophie

IPC: A61B5/097 ,  A61B5/08 ,  G01N1/22

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240; 340) therebetween; wherein inlets (210; 310) and outlets (230; 330) are configured for transporting a flow of air (104) into and out of the particle collection chamber (240; 340) and configured for allowing capturing airborne particles by impaction. The collecting device (200) further comprises at least one liquid access port (260; 260a, 260b; 360a-360h) for filling the particle collection chamber (240; 340) with a reagent; and wherein the particle collection chamber (240; 340) comprises at least one side wall (246; 346) for defining flow of the reagent, such that a first portion (248a; 348a) and a second portion (248b; 348b) of the particle collection chamber (240; 340) are arranged on opposite sides of the at least one side wall (246; 346).

公开(公告)号：WO2022079195A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/078509

申请日：2021-10-14

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  JONES, Benjamin ,  ROTTENBERG, Xavier ,  LIU, Chengxun ,  TAHER, Ahmed

IPC: G01N1/22 ,  A61B5/00 ,  A61B5/097

Abstract: A collecting device (200) for collection of particles and presentation of collected particles for analysis comprises: a first layer (202) and a second layer (220) spaced apart for defining a particle collection chamber (240); wherein the first layer (202) is configured to receive a flow of air (104) carrying airborne particles, wherein the first layer (202) comprises a plurality of inlet nozzles (210) configured to extend through the first layer (202) for transporting the flow of air (104) therethrough; wherein the inlet nozzles (210) are configured to face a first surface (222) of the second layer (220) for capturing airborne particles in the flow of air (104) entering the particle collection chamber (240) by impaction of airborne particles; wherein the collecting device (200) is configured to provide optical access for performing a measurement, based on light, of airborne particles collected in the particle collection chamber (240).

公开(公告)号：WO2022079197A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/078512

申请日：2021-10-14

Applicant: IMEC VZW

Inventor： TAHER, Ahmed ,  JONES, Benjamin ,  PEUMANS, Peter

IPC: G01N1/22 ,  A61B5/00 ,  A61B5/08 ,  A61B5/097

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240) therebetween, wherein inlets (210) extend through the first layer (202) for transporting a flow of air into the particle collection chamber (240); wherein ends (214) of the inlets (210) face a first surface (222) of the second layer (220) for capturing airborne particles by impaction; wherein outlets (230) extend through the second layer (220) for transporting the flow of air out of the particle collection chamber (240); wherein the inlets (210) and outlets (230) are staggered such that the center axes of the inlets (210) and outlets (230) are displaced from each other; wherein the flow of air experiences a pressure drop lower than 3 kPa at a flow rate of 0.5 liters per second, when the flow of air passes the collecting device (200).

公开(公告)号：WO2020126985A1

公开(公告)日：2020-06-25

申请号：PCT/EP2019/085258

申请日：2019-12-16

Applicant: IMEC VZW ,  KATHOLIEKE UNIVERSITEIT LEUVEN

Inventor： PEUMANS, Peter ,  TAHER, Ahmed ,  VERGAUWE, Nicolas ,  JONES, Benjamin

IPC: B01L3/00 ,  B01J19/00 ,  C12M3/06

Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro- reaction chambers (10) to the reagent outlet (9).

公开(公告)号：WO2016203051A1

公开(公告)日：2016-12-22

申请号：PCT/EP2016/064217

申请日：2016-06-20

Applicant: IMEC VZW

Inventor： JONES, Benjamin ,  STAKENBORG, Tim ,  FIORINI, Paolo

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502707 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00637 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/086 ,  B05C7/04 ,  F16K99/0021

Abstract: A fluidic device (100) is described for locally coating an inner surface of a fluidic channel. The fluidic device (100) comprises a first (101), a second (102) and a third (103) fluidic channel intersecting at a common junction (105). The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device (100) further comprises a fluid control means (111) configured for creating a fluidic flow path for a coating fluid at the common junction (105) such that, when coating, a coating fluid propagates from the first (101) to the second (102) fluidic channel via the common junction (105) without propagating into the third (103) fluidic channel. A corresponding method for coating and for sensing also has been disclosed.

Abstract translation: 描述了用于局部涂覆流体通道的内表面的流体装置（100）。 流体装置（100）包括在公共接头（105）处相交的第一（101），第二（102）和第三（103）流体通道。 第一流体通道可连接到涂层流体储存器，并且第三流体通道可连接到样品流体储存器。 流体装置（100）还包括流体控制装置（111），其配置用于在公共接头（105）处产生用于涂覆流体的流体流路，使得当涂覆时，涂覆流体从第一（101）传播到 所述第二（102）流体通道经由所述公共接头（105）而不传播到所述第三（103）流体通道中。 已经公开了用于涂覆和感测的相应方法。

公开(公告)号：EP4329606A1

公开(公告)日：2024-03-06

申请号：EP22723662.7

申请日：2022-04-20

Applicant: Imec VZW

Inventor： TAHER, Ahmed ,  JONES, Benjamin ,  ROTH, Sophie

IPC: A61B5/097 ,  A61B5/08 ,  G01N1/22

公开(公告)号：EP4019134A1

公开(公告)日：2022-06-29

申请号：EP21216263.0

申请日：2021-12-21

Applicant: Imec VZW

Inventor： JONES, Benjamin ,  CHOE, Young Jae

IPC: B01L3/00

Abstract: A microfluidic device unit (1) comprising: (a) a unit inlet (10) and a unit outlet (14), (b) a cavity (11) comprising a fluidic channel (112), (c) a fluidic resistor (12), and (d) a filter (130), wherein the unit inlet (10), the unit outlet (14), the fluidic channel (112), and the fluidic resistor (12) are fluidically coupled to one another, wherein the cavity (11), the fluidic resistor (12), and the filter (13) are between the unit inlet (10) and the unit outlet (14), wherein the cavity (11) is upstream of the fluidic resistor (12), and wherein the filter (13) is positioned so as to filter fluid after it enters the fluidic channel (112) and before it enters the fluidic resistor (12).

公开(公告)号：EP3944894A1

公开(公告)日：2022-02-02

申请号：EP20188567.0

申请日：2020-07-30

Applicant: Imec VZW

Inventor： TAHER, Ahmed ,  JONES, Benjamin

IPC: B01L3/00

Abstract: A flow control system for a microfluidic device (110) comprises: a plurality of fluid flow controllers (152), each fluid flow controller (152) being configured to be associated with a microfluidic device inlet (112) of the microfluidic device (110), wherein each fluid flow controller (152) comprises: a controller inlet (154) for receiving a fluid flow, a first fluid channel (156) and a second fluid channel (158), each of the first and the second fluid channels (156, 158) having a first end connected to the controller inlet (154) and a second end connected to a supply channel (162), and a valve (160) for selecting the fluid flow to be passed from the controller inlet (154) to the first fluid channel (156) or the second fluid channel (158), wherein the first fluid channel (156) has a first flow resistance smaller than a second flow resistance of the second fluid channel (158).

公开(公告)号：EP3885042A1

公开(公告)日：2021-09-29

申请号：EP20165314.4

申请日：2020-03-24

Applicant: Imec VZW

Inventor： FIORENTINO, Giuseppe ,  HUMBERT, Aurelie ,  SEVERI, Simone ,  JONES, Benjamin

IPC: B01L3/00 ,  B81C1/00 ,  A61K9/00

Abstract: A method for fabricating a microfluidic device, comprising:
a. Providing an assembly comprising:
i. a first silicon substrate having a hydrophilic silicon oxide top surface comprising a microfluidic channel,
ii. a second silicon substrate, having a hydrophilic silicon oxide bottom surface directly bonded on the top surface of the first silicon substrate, and comprising fluidic access holes giving fluidic access to the microfluidic channel, and

b. Exposing the assembly to oxidative species comprising one or more oxygen atoms and to heat so as to form silicon oxide at a surface of the access holes and of the microfluidic channel.

公开(公告)号：EP3505248A1

公开(公告)日：2019-07-03

申请号：EP17210767.4

申请日：2017-12-28

Applicant: IMEC vzw

Inventor： JONES, Benjamin

IPC: B01L3/00

Abstract: A microfluidic device comprising a reaction chamber and at least two fluidic channels coupled to the reaction chamber is disclosed. The at least two fluidic channels allow providing/exiting a fluid in/from the reaction chamber (100, 200), each fluidic channel comprising an inlet (101, 102, 201, 202, 203, 204, 301, 302, 303) and an outlet (111, 112, 211, 212, 213, 214). Each fluidic channel is configured such that when a fluid is provided in the reaction chamber via that fluidic channel, the fluid exits the reaction chamber via the outlet of at least one other fluidic channel when the reactor is filled, thereby preventing a fluid from the at least one other fluidic channel, when present in the inlet, from diffusing into the reaction chamber.