公开(公告)号：US20210162410A1

公开(公告)日：2021-06-03

申请号：US16954140

申请日：2018-12-14

Applicant: Indian Institute of Science

Inventor： Jatin Panwar ,  Rahul Roy ,  Usama Ahmed Abbasi ,  Prakhar Jain ,  Viswanathan Kumaran

IPC: B01L3/00 ,  G01N15/10 ,  B81B1/00 ,  B81C1/00

Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.

公开(公告)号：US11707738B2

公开(公告)日：2023-07-25

申请号：US16954140

申请日：2018-12-14

Applicant: Indian Institute of Science

Inventor： Jatin Panwar ,  Rahul Roy ,  Usama Ahmed Abbasi ,  Prakhar Jain ,  Viswanathan Kumaran

IPC: B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  G01N15/10

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/502761 ,  B81B1/006 ,  B81C1/00119 ,  G01N15/1031 ,  G01N15/1056 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0887 ,  B81B2201/057 ,  B81B2203/0338 ,  B81B2203/04

Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.