中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.02 seconds)

    DERIVATIVES OF TETRACYCLIC SUBSTITUTED AZEPINES EXHIBITING AFFINITY IN RESPECT TO 5-HT2 RECEPTORS
    2.
    发明专利
    DERIVATIVES OF TETRACYCLIC SUBSTITUTED AZEPINES EXHIBITING AFFINITY IN RESPECT TO 5-HT2 RECEPTORS 未知

    公开(公告)号：PL183686B1

    公开(公告)日：2002-06-28

    申请号：PL31993995

    申请日：1995-10-25

    Applicant: JANSSEN PHARMACEUTICA NV

    Inventor： SIPIDO VICTOR K ,  FERNANDEZ-GADEA FRANCISCO J ,  ANDRES-GIL JOSE I ,  MEERT THEO F ,  GIL-LOPETEGUI PILAR

    IPC: A61K31/535 ,  A61K31/55 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/20 ,  C07D223/30 ,  C07D261/00 ,  C07D498/04 ,  A61K31/553

    Abstract: This invention concerns the compounds of formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. (I) wherein: R1 and R2 each independently are hydrogen; C1-6alkyl; C1-6alkylcarbonyl; trihalomethylcarbonyl; C1-6alkyl substituted with hydroxy, C1-6alkyloxy, carboxyl, C1-6alkylcarbonyloxy, C1-6alkyloxycarbonyl or aryl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; R3, R4, R5, R6, R9, R10, R11 or R12 each independently are hydrogen, halo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, carboxyl, nitro, amino, mono- or di(C1-6alkyl)-amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)-aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl, C1-6alkyloxy-carbonyl; R7 and R8 are each independently hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy or R7 and R8 taken together may form mono- or di(cyano)methylene, or together with the carbon atom to which they are attached form a carbonyl or a spiro substituent; or R7 and R8 taken together may form methylene; R13 is hydrogen, C1-6alkyl, or trifluoromethyl; R14 is hydrogen, C1-6alkyl, cyano, or trifluoromethyl; n is zero to 6. These compounds were tested as mCPP-antagonists in rats. The compounds of formula (I) may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.

Patent Agency Ranking