Patent search ap:("JANSSEN PHARMACEUTICA NV") AND inv:"TEN HOLTE PETER" Page 1

1.

发明专利
Mtki quinazoline derivative 有权
Title translation: MTKI喹诺酮衍生物

公开(公告)号：JP2013249307A

公开(公告)日：2013-12-12

申请号：JP2013167044

申请日：2013-08-09

Applicant: Janssen Pharmaceutica Nv , ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap

Inventor： PAPANIKOS ALEXANDRA , FREYNE EDDY JEAN EDGARD , TEN HOLTE PETER , WILLEMS MARC , EMBRECHTS WERNER CONSTANT JOHAN , MEVELLEC LAURENCE ANNE , STORCK PIERRE HENRI

IPC: C07D498/18 , A61K31/519 , A61K31/541 , A61P9/00 , A61P9/10 , A61P35/00 , A61P43/00

CPC classification number: C07D498/14 , C08K5/544

Abstract: PROBLEM TO BE SOLVED: To provide a certain kind of new quinazoline derivative, having an antitumor activity and useful in a treating method for a human body or an animal body.SOLUTION: A quinazoline derivative is expressed by formula (I) (wherein, Y, X, X, R, Rand Rare each optionally a halogen atom or an organic group) or its N-oxy form, pharmaceutically acceptable addition salt or stereochemically isomeric form.

Abstract translation: 要解决的问题：提供一种具有抗肿瘤活性并可用于人体或动物体的治疗方法的新型喹唑啉衍生物。解决方案：喹唑啉衍生物由式（I）表示（其中Y为，X，X，R，R 3各自任选是卤素原子或有机基团）或其N-氧基形式，药学上可接受的加成盐或立体化学异构形式。

2.

发明申请
MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI 审中-公开
Title translation: 大分子喹唑啉衍生物及其作为MTKI的用途

公开(公告)号：WO2006061417A3

公开(公告)日：2006-08-03

申请号：PCT/EP2005056609

申请日：2005-12-08

Applicant: JANSSEN PHARMACEUTICA NV , FREYNE EDDY JEAN EDGARD , WILLEMS MARC , TEN HOLTE PETER , PAPANIKOS ALEXANDRA , EMBRECHTS WERNER CONSTANT JOHA , STORCK PIERRE HENRI , PONCELET VIRGINIE SOPHIE

Inventor： FREYNE EDDY JEAN EDGARD , WILLEMS MARC , TEN HOLTE PETER , PAPANIKOS ALEXANDRA , EMBRECHTS WERNER CONSTANT JOHA , STORCK PIERRE HENRI , PONCELET VIRGINIE SOPHIE

IPC: C07D498/08 , A61K31/529 , A61P35/00 , C07D239/00 , C07D273/00

CPC classification number: C07D498/06 , C07D498/08

Abstract: The present invention concerns kinase inhibitors formula, formula (I), the N-oxide forms, the pharmaceutically isomeric forms thereof, wherein Z represents NH and the other substituents are defined as in the claims.

Abstract translation: 本发明涉及激酶抑制剂式（I），N-氧化物形式及其药学上异构体形式，其中Z表示NH且其它取代基如权利要求中所定义。

3.

发明申请
MTKI QUINAZOLINE DERIVATIVES 审中-公开
Title translation: MTKI喹诺酮衍生物

公开(公告)号：WO2008006884A3

公开(公告)日：2008-03-06

申请号：PCT/EP2007057200

申请日：2007-07-12

Applicant: JANSSEN PHARMACEUTICA NV , PAPANIKOS ALEXANDRA , FREYNE EDDY JEAN EDGARD , TEN HOLTE PETER , WILLEMS MARC , EMBRECHTS WERNER CONSTANT JOHA , MEVELLEC LAURENCE ANNE , STORCK PIERRE HENRI

Inventor： PAPANIKOS ALEXANDRA , FREYNE EDDY JEAN EDGARD , TEN HOLTE PETER , WILLEMS MARC , EMBRECHTS WERNER CONSTANT JOHA , MEVELLEC LAURENCE ANNE , STORCK PIERRE HENRI

IPC: C07D498/14 , A61K31/519 , A61P35/00

CPC classification number: C07D498/14 , C08K5/544

Abstract: The present invention concerns the compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y represents -C 3-9 alkyl-, -C 1-5 alkyl-NR 6 -C 1-5 alkyl- or -C 1-5 alkyl-NR 7 -CO-C 1-5 alkyl-; X 1 represents -O-; X 2 represents NR 5 -C 1-2 alkyl-; R 1 represents hydrogen, halo or Het 3 -O-; R 2 represents hydrogen; R 3 represents hydroxy, C 1-4 alkyloxy- or C 1-4 alkyloxy subst ituted with one or two substituents each independently selected from Het 4 , hydroxy, C 1-4 alkyloxy-, C 1-4 alkyloxy-C 1-4 alkyloxy and NR 9 R 10 ; R 5 represents hydrogen or C 1-4 alkyl; R 6 represents hydrogen or C 1-4 alkyl; R 7 represents hydrogen; R 9 and R 10 each independently represent hydrogen; C 1-4 alkyl-S(=O) 2 -C 1-4 alkyl-C(=O)-; C 1-4 alkyl or C 1-4 alkyl substituted with hydroxy; Het 3 represents pyridinyl optionally substituted with C 1-4 alkyl; Het 4 represents morpholinyl, piperidinyl or piperazinyl wherein said Het 4 is optionally substituted with hydroxy-C 1-4 alkyl or C 1-4 alkyl-S(=O) 2 -C 1-4 alkyl-.

Abstract translation: 本发明涉及式（I）化合物的N-氧化物形式，其药学上可接受的加成盐和立体化学异构形式，其中Y代表-C 3-9 - 烷基 - ， - 烷基-C 1-6烷基-C 1-6烷基-C 1-6烷基-C 1-6烷基-C 1-6烷基-C 1-6烷基-C ^{7 -CO-C _{1-5 烷基 - ; X 1表示-O-; X 2表示NR 5 -C 12烷基 - ; R 1表示氢，卤素或Het 3 -O-; R 2表示氢; R 3表示羟基，C 1-4烷基氧基或C 1-4烷氧基，其被一个或两个独立地选自Het的取代基取代羟基，C 1-4烷氧基 - ，C 1-4烷基氧基-C 1-4烷氧基（C 1 -C 4）烷基氧基和NR 9 R 10; R 5表示氢或C 1-4烷基; R 6表示氢或C 1-4烷基; R 7表示氢; R 9和R 10各自独立地表示氢; ç_{1-4 烷基-S（= O）_{2 -C _{1-4 烷基-C（= O） - ; C 1-4烷基或被羟基取代的C 1-4烷基; Het 3表示任选被C 1-4烷基取代的吡啶基; Het 4表示吗啉基，哌啶基或哌嗪基，其中所述Het 4任选被羟基-C 1-4烷基或C 1〜 -4 烷基-S（= O）_{2 -C _{1-4 烷基 - 。}}}}}}}

4.

发明专利
IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 未知

公开(公告)号：CA2608929C

公开(公告)日：2014-01-28

申请号：CA2608929

申请日：2006-06-20

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： TEN HOLTE PETER , VAN EMELEN KRISTOF , ANGIBAUD PATRICK RENE , MARCONNET-DECRANE LAURENCE FRANCOISE BERNADETTE , MEERPOEL LIEVEN

IPC: C07D401/14 , A61K31/4166 , A61P35/00 , C07D413/14

Abstract: This invention comprises the novel compounds of Formula (I) wherein R1, R2, R3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

5.

发明专利
未知

公开(公告)号：BRPI0717314A2

公开(公告)日：2014-01-21

申请号：BRPI0717314

申请日：2007-10-22

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： MEERPOEL LIEVEN , BACKX LEO JACOBUS JOZEF , TEN HOLTE PETER , BUSSCHER GUUSKE FREDERIKE

IPC: C07C235/52 , A61K31/216 , A61K31/40 , A61K31/4025 , A61K31/5377 , A61K31/55 , C07C231/02 , C07C231/16 , C07C233/57 , C07C233/78 , C07C235/54 , C07C235/60 , C07D207/14 , C07D223/12 , C07D265/30

Abstract: The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).

6.

发明专利
SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 未知

公开(公告)号：CA2572833C

公开(公告)日：2013-04-09

申请号：CA2572833

申请日：2005-07-25

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： VERDONCK MARC GUSTAAF CELINE , ANGIBAUD PATRICK RENE , ROUX BRUNO , PILATTE ISABELLE NOELLE CONSTANCE , TEN HOLTE PETER , ARTS JANINE , VAN EMELEN KRISTOF

IPC: C07D401/14 , A61K31/506 , A61P35/00 , C07D405/14 , C07D409/14

Abstract: This invention comprises the novel compounds of formula (I) wherein R1 , R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

7.

发明专利
ПРОИЗВОДНЫЕ ТЕТРАГИДРОНАФТАЛИН-1-КАРБОНОВОЙ КИСЛОТЫ, ИНГИБИРУЮЩИЕ МТР 未知

公开(公告)号：EA017376B1

公开(公告)日：2012-12-28

申请号：EA200970399

申请日：2007-10-22

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： MEERPOEL LIEVEN , BACKX LEO JACOBUS JOSEF , TEN HOLTE PETER , BUSSCHER GUUSKE FREDERIKE

IPC: C07C235/52 , A61K31/216 , A61K31/40 , A61K31/4025 , A61K31/5377 , A61K31/55 , C07C231/02 , C07C231/16 , C07C233/57 , C07C233/78 , C07C235/54 , C07C235/60 , C07D207/14 , C07D223/12 , C07D265/30

Abstract: Настоящееизобретениеотноситсяк новымпроизводнымтетрагидронафталин-1-карбоновойкислоты, обладающимапоВсекрецией/МТРингибирующейактивностьюи сопутствующейгиполипидемическойактивностью. Изобретение, крометого, относитсяк способамполучениятакихсоединений, фармацевтическихкомпозиций, включающихуказанныесоединения, атакжек применениюуказанныхсоединенийв качествелекарственныхсредствдлялеченияатеросклероза, панкреатита, ожирения, гипертриглицеридемии, гиперхолестеролемии, гиперлипидемии, диабетаи диабета II типа.