公开(公告)号：US20170283787A1

公开(公告)日：2017-10-05

申请号：US15505656

申请日：2015-08-26

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Hiroshi Abe ,  Hideto MARUYAMA

IPC: C12N15/09 ,  C07H21/00 ,  C12P19/34 ,  C12Q1/68

CPC classification number: C12N15/09 ,  C07H1/00 ,  C07H21/00 ,  C12N2310/10 ,  C12N2310/141 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6811

Abstract: Provided, as a technique for binding a nucleic acid chain and a nucleic acid chain by a natural structure or an analogous structure thereto, is a non-enzymatic nucleic acid chain binding method, which is a method for binding a nucleic acid chain and a nucleic acid chain not via an enzymatic reaction, including a step of reacting a nucleic acid chain having a phosphorothioate group and a nucleic acid chain having a hydroxyl group or amino group in the presence of an electrophile.