公开(公告)号：US11848075B2

公开(公告)日：2023-12-19

申请号：US16612276

申请日：2018-05-11

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Luonan Chen ,  Kazuyuki Aihara ,  Xiaoping Liu

IPC: G16B50/30 ,  G01N33/574 ,  A61B5/00 ,  G16B40/00 ,  G16B30/10 ,  G06T7/00

CPC classification number: G16B40/00 ,  A61B5/7246 ,  G01N33/57484 ,  G16B30/10 ,  G16B50/30 ,  G01N2800/60 ,  G06T7/0012 ,  G06T2207/30004

Abstract: Provided is a method for detecting a biomarker indicating states of a target biological system based on data acquired by measuring the target biological system. The method includes the steps of: preparing a reference dataset based on data acquired from one or more reference biological systems; generating a target dataset by adding, to the reference dataset, target biological data acquired from the target biological system; acquiring first correlation coefficients between a plurality of factor items in the reference dataset; acquiring second correlation coefficients between the plurality of factor items in the target dataset; acquiring difference correlation coefficients that are differences between the first correlation coefficients and the second correlation coefficients; acquiring indexes respectively for the plurality of factor items based on the difference correlation coefficients; and selecting the biomarker based on the indexes.