公开(公告)号：US20180360819A1

公开(公告)日：2018-12-20

申请号：US16113150

申请日：2018-08-27

Applicant: Japan Science and Technology Agency

Inventor： Yoshihiro KAWAOKA ,  Tokiko WATANABE ,  Eiryo KAWAKAMI ,  Shinji WATANABE

IPC: A61K31/473 ,  C12Q1/68 ,  A61K45/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/48 ,  A61K31/713 ,  C07K14/47 ,  G01N33/50 ,  C12Q1/6876 ,  A61K31/519 ,  C12N9/12

Abstract: The present invention provides an anti-influenza virus agent that targets biomolecules of host cells including human cells and a method of screening a candidate molecule for the anti-influenza virus agent. That is, the present invention is an anti-influenza virus agent that has an effect of suppressing expression or a function of a gene that encodes a protein having an effect of suppressing incorporation of an influenza virus vRNA or an NP protein into influenza virus-like particles in host cells and the gene is at least one selected from the group including JAK1 gene and the like.

公开(公告)号：US20190314489A1

公开(公告)日：2019-10-17

申请号：US16453464

申请日：2019-06-26

Applicant: Japan Science and Technology Agency

Inventor： Yoshihiro KAWAOKA ,  Tokiko Watanabe ,  Eiryo Kawakami ,  Shinji Watanabe

IPC: A61K39/145 ,  C12N5/00 ,  C12N7/08 ,  C12N5/071 ,  C12N5/10 ,  C12N15/113 ,  C12N7/02

Abstract: The present invention provides cells which have a high ability to propagate influenza virus, are suitable for use in production of an influenza virus for preparing a vaccine, and are able to be cultured in vitro, and a method for producing an influenza virus using the cells. That is, the present invention provides cells for producing an influenza virus in which expression of one or more genes that encode proteins involved in an effect of suppressing influenza virus production in a cell is suppressed and the gene is at least one selected from the group including ACTG1 gene and the like, and a method for producing an influenza virus that includes infecting the cells for producing an influenza virus with an influenza virus and then culturing.

公开(公告)号：US20180104327A1

公开(公告)日：2018-04-19

申请号：US15511988

申请日：2015-09-18

Applicant: Japan Science and Technology Agency

Inventor： Yoshihiro KAWAOKA ,  Tokiko WATANABE ,  Eiryo KAWAKAMI ,  Shinji WATANABE

IPC: A61K39/145 ,  C12N5/10 ,  C12N5/071 ,  C12N7/02 ,  C12N15/113 ,  C12N7/08

CPC classification number: A61K39/145 ,  C12N5/00 ,  C12N5/0686 ,  C12N5/10 ,  C12N7/02 ,  C12N7/08 ,  C12N15/113 ,  C12N2760/16051

Abstract: The present invention provides cells which have a high ability to propagate influenza virus, are suitable for use in production of an influenza virus for preparing a vaccine, and are able to be cultured in vitro, and a method for producing an influenza virus using the cells. That is, the present invention provides cells for producing an influenza virus in which expression of one or more genes that encode proteins involved in an effect of suppressing influenza virus production in a cell is suppressed and the gene is at least one selected from the group including ACTG1 gene and the like, and a method for producing an influenza virus that includes infecting the cells for producing an influenza virus with an influenza virus and then culturing.

公开(公告)号：US20170290821A1

公开(公告)日：2017-10-12

申请号：US15511930

申请日：2015-09-18

Applicant: Japan Science and Technology Agency

Inventor： Yoshihiro KAWAOKA ,  Tokiko WATANABE ,  Eiryo KAWAKAMI ,  Shinji WATANABE

IPC: A61K31/473 ,  A61K31/519 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/48

CPC classification number: A61K31/473 ,  A61K31/519 ,  A61K31/713 ,  A61K45/00 ,  C07K14/47 ,  C07K2319/43 ,  C12N9/12 ,  C12N15/09 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2760/16111 ,  C12N2760/16122 ,  C12Q1/485 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Y207/10002 ,  G01N33/50 ,  G01N33/5023 ,  G01N2333/11 ,  G01N2500/10

Abstract: The present invention provides an anti-influenza virus agent that targets biomolecules of host cells including human cells and a method of screening a candidate molecule for the anti-influenza virus agent. That is, the present invention is an anti-influenza virus agent that has an effect of suppressing expression or a function of a gene that encodes a protein having an effect of suppressing incorporation of an influenza virus vRNA or an NP protein into influenza virus-like particles in host cells and the gene is at least one selected from the group including JAK1 gene and the like.