公开(公告)号：WO2018096504A1

公开(公告)日：2018-05-31

申请号：PCT/IB2017/057403

申请日：2017-11-27

Applicant: KALYTERA THERAPEUTICS, INC

Inventor： SALZMAN, Andrew ,  FLOWER, Kevin ,  GARNER, C. Edwin ,  JAGTAP, Parkash ,  MUSA, Saana

IPC: C07F9/38 ,  C07C279/14 ,  C07C203/10 ,  C07C305/24 ,  C07C229/18 ,  C07F9/40 ,  A61K31/255 ,  A61P17/00

CPC classification number: C07F9/3834 ,  A61P17/10 ,  C07C201/02 ,  C07C203/10 ,  C07C227/20 ,  C07C269/06 ,  C07C277/08 ,  C07C279/14 ,  C07C303/24 ,  C07C305/24 ,  C07C2603/18 ,  C07F9/3882 ,  C07F9/4006 ,  C07C229/06 ,  C07C271/22

Abstract: Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R 1 and R 2 are each independently selected from -H, -SO 3 Na, -PO(ONa) 2 , -PO(OCH 2 CH 3 ), -CH 2 PO(ONa) 2 , -NO 2 , -(L)-valine ester, -(L)-N-methyl arginine ester, -α-guanidinoglutaric acid ester, -2-iminobiotin ester, -3- hydroxy anthranilic acid ester, -(L)-nitroarginine ester, -(L)- N5-(1-iminoethyl)-(L)- ornithine (NIO) ester, -(L)-N,N dimethylarginine ester, -(L)- N6-(1-iminoethyl)-(L)-lysine (NIL) ester, -(L)- N-monomethyl-(L)-arginine (NMMA) ester, -N-amino-(L)-arginine ester, -N-propyl-(L)-arginine ester, -S-methyl-(L)-thiocitrulline ester, -methyl-(L)-NIO ester, - vinyl -(L)-NIO ester, and -propenyl-(L)-NK) ester; and wherein when X is a direct bond, R 1 and R 2 are Formula (II).