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    Affinity carrier for purifying or removing protein or peptide having kringle sequence and method for purifying and removing the same
    3.
    发明专利
    Affinity carrier for purifying or removing protein or peptide having kringle sequence and method for purifying and removing the same 有权
    用于净化或去除具有克隆序列的蛋白质或肽的亲和载体和用于净化和除去其的方法

    公开(公告)号：JP2012062259A

    公开(公告)日：2012-03-29

    申请号：JP2010206171

    申请日：2010-09-14

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： SATO NOBUHIKO ,  ITAGAKI YOSHIFUMI

    IPC: C07K1/22 ,  C07K1/04 ,  C07K14/47

    Abstract: PROBLEM TO BE SOLVED: To provide an affinity carrier for removing or purifying a protein or a peptide having the Kringle sequence, including a plasminogen, and to provide a method for removing or purifying the protein or peptide having the Kringle sequence using the affinity carrier.SOLUTION: The protein or peptide having the Kringle sequence can efficiently be removed and purified with the affinity carrier which is obtained by bringing an activated carrier into contact with lysine at pH≤9 and contains the lysine immobilized therein. Furthermore, there is provided the method for purifying and removing the protein or peptide having the Kringle sequence using the affinity carrier.

    Abstract translation: 待解决的问题：提供一种用于除去或纯化包含纤溶酶原的具有Kringle序列的蛋白质或肽的亲和载体，并提供使用该方法除去或纯化具有Kringle序列的蛋白质或肽的方法 亲和载体。 解决方案：具有Kringle序列的蛋白质或肽可以通过使活化载体与pH≤9的赖氨酸接触并含有固定在其中的赖氨酸获得的亲和载体有效地除去和纯化。 此外，提供了使用亲和载体来纯化和去除具有Kringle序列的蛋白质或肽的方法。 版权所有（C）2012，JPO＆INPIT

    Method for immobilizing two or more kinds of molecule in porous carrier
    4.
    发明专利
    Method for immobilizing two or more kinds of molecule in porous carrier 审中-公开
    用于在多孔载体中固定两种或更多种分子的方法

    公开(公告)号：JP2012050387A

    公开(公告)日：2012-03-15

    申请号：JP2010196182

    申请日：2010-09-01

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： ITAGAKI YOSHIFUMI ,  SATO NOBUHIKO ,  KITAGUCHI KANA ,  OGINO EIJI ,  NISHIMURA NAOKO

    IPC: C12N11/06

    Abstract: PROBLEM TO BE SOLVED: To provide in large quantity and in a stable quality a column packing agent where a protein and molecules having functions different from those of the protein are immobilized in an activated porous carrier.SOLUTION: The column packing agent wherein the protein and molecules having functions different from those of the protein are immobilized in a porous carrier are prepared with stable quality, even in case of preparing a large quantity of the packing agent, when the protein and the molecules having functions different from those of the protein are immobilized in the porous carrier, by conducting a continuous one-pot reaction even when the replacing operation of the reaction liquid is skipped during the immobilizing reaction.

    Abstract translation: 要解决的问题：为了提供大量和稳定的质量的柱填充剂，其中具有与蛋白质不同的功能的蛋白质和分子被固定在活化的多孔载体中。 解决方案：即使在制备大量包装剂的情况下，即使在制备大量包装剂的情况下，也可以制备质量稳定的蛋白质和蛋白质分子与蛋白质不同的柱状填充剂， 并且具有与蛋白质功能不同的功能的分子固定在多孔载体中，即使在固定化反应期间跳过反应液体的更换操作，也进行连续一锅反应。 版权所有（C）2012，JPO＆INPIT

    Process for preparation of 2-aminotetralin derivative, and intermediate thereof
    5.
    发明专利
    Process for preparation of 2-aminotetralin derivative, and intermediate thereof 审中-公开
    2-氨基嘌呤衍生物的制备方法及其中间体

    公开(公告)号：JP2009005686A

    公开(公告)日：2009-01-15

    申请号：JP2008130888

    申请日：2008-05-19

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： HONDA TATSUYA ,  FUJII AKIO ,  INOUE KENJI ,  YASOHARA YOSHIHIKO ,  ITAGAKI YOSHIFUMI ,  MAEHARA KATSUHARU ,  TAKEDA TOSHIHIRO ,  UEDA YASUYOSHI

    IPC: C12P7/22 ,  C07C213/02 ,  C07C217/74 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07D209/48 ,  C12P7/42

    CPC classification number: C12P7/42 ,  C07B2200/07 ,  C07C213/02 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07C217/74

    Abstract: PROBLEM TO BE SOLVED: To provide a process for efficiently and readily producing an optically active 7-substituted-2-aminotetralin, with industrial advantage. SOLUTION: The process for the preparation of an optically active 7-substituted-2-aminotetralin or its salt includes reduction of a 7-substituted-2-tetralone or a bisulfite adduct thereof, with a microorganism into an optically active 7-substituted-2-tetralol; introduction of a sulfonyl group into the hydroxyl group of the tetralol, to obtain an optically active 7-substituted-2-sulfonyloxytetralin; introduction of a nitrogen substituent into the resulting tetralin by the use of a nitrogen nucleophile through steric inversion, to obtain an optically active 2,7-substituted tetralin; and if necessary, the conversion of the nitrogen substituent into an unsubstituted amino group. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种有效且容易地制造具有工业优势的光学活性7-取代-2-氨基四氢萘酚的方法。 解决方案：制备光学活性7-取代-2-氨基四氢萘或其盐的方法包括将微生物的7-取代-2-四氢萘酮或其亚硫酸氢盐加合物还原成光学活性7- 取代-2-四氢萘酚 在四氢化萘的羟基中引入磺酰基，得到光学活性的7-取代-2-磺酰氧基四氢萘酮; 通过使用氮亲核试剂通过空间倒置将氮取代基引入所得的四氢化萘中，得到光学活性的2,7-取代的四氢化萘; 并且如果需要，将氮取代基转化为未取代的氨基。 版权所有（C）2009，JPO＆INPIT

    Adsorbent and adsorber for pcsk9
    6.
    发明专利
    Adsorbent and adsorber for pcsk9 有权
    PCSK9的吸引力和吸引力

    公开(公告)号：JP2013017644A

    公开(公告)日：2013-01-31

    申请号：JP2011153216

    申请日：2011-07-11

    Applicant: National Cerebral & Cardiovascular Center ,  独立行政法人国立循環器病研究センター ,  Kaneka Corp ,  株式会社カネカ

    Inventor： SHIBA MARIKO ,  YUASA YUMIKO ,  OGINO EIJI ,  ITAGAKI YOSHIFUMI ,  KITAGUCHI KANA

    IPC: A61M1/36

    Abstract: PROBLEM TO BE SOLVED: To provide an adsorbent that can efficiently adsorb and remove PCSK9 in body fluid, and to provide an adsorber.SOLUTION: The adsorbent 3 of the PCSK9 includes a water insoluble carrier having an anionic functional group. Moreover, the adsorber 7 of the PCSK9 is filled with the adsorbent 3 of the PCSK9 in a container with a liquid inlet 1 and a liquid outlet 2 and a flowout prevention means 5 for preventing the adsorbent 3 from flowing out the container.

    Abstract translation: 要解决的问题：提供能够有效吸附和去除体液中的PCSK9并提供吸附剂的吸附剂。 解决方案：PCSK9的吸附剂3包括具有阴离子官能团的水不溶性载体。 此外，PCSK9的吸附器7在具有液体入口1和液体出口2的容器中填充PCSK9的吸附剂3，并且防止吸附剂3流出容器的防止流出装置5。 版权所有（C）2013，JPO＆INPIT

    Column filled up with two or more kinds of porosity fillers
    7.
    发明专利
    Column filled up with two or more kinds of porosity fillers 审中-公开
    柱填充两种或更多种类型的孔隙填料

    公开(公告)号：JP2012050386A

    公开(公告)日：2012-03-15

    申请号：JP2010196181

    申请日：2010-09-01

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： ITAGAKI YOSHIFUMI ,  SATO NOBUHIKO ,  KITAGUCHI KANA ,  OGINO EIJI

    IPC: C12M1/40

    CPC classification number: C12M21/18 ,  C12M25/16

    Abstract: PROBLEM TO BE SOLVED: To provide a column for obtaining purification efficiency of BL-angiostatin equal to or more than a sepharose system carrier in a carrier other than the sepharose system carrier.SOLUTION: An affinity trap reactor can suppress generation of excessive resolvent by dividing into two kinds of carriers in which enzyme and a molecule with affinity for the resolvent by the enzyme are individually immobilized, and having the column in order of enzyme reaction and condensation of the resolvent by the enzyme.

    Abstract translation: 待解决的问题：提供用于获得等于或大于琼脂糖系统载体以外的载体的琼脂糖凝胶系统载体的BL-血管抑素的纯化效率的柱。 解决方案：亲和陷阱反应器可以通过分为两种载体来抑制过度溶解的产生，其中酶和对酶的溶解度具有亲和力的分子被单独固定，并且具有酶的反应顺序的柱和 溶剂由酶缩合。 版权所有（C）2012，JPO＆INPIT

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