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    SELECTIVE HUMAN β3 ADRENALIN RECEPTOR AGONIST AGENT
    7.
    发明专利
    SELECTIVE HUMAN β3 ADRENALIN RECEPTOR AGONIST AGENT 审中-公开
    选择性人类β3ADRENALIN受体激动剂

    公开(公告)号：JP2006096666A

    公开(公告)日：2006-04-13

    申请号：JP2002317294

    申请日：2002-10-31

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： MAE TATSUMASA ,  TSUKAGAWA YOSHIHISA ,  KONISHI EISAKU ,  KAWADA TERUO

    IPC: A61K36/75 ,  A23L1/30 ,  A61K36/758 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P19/06 ,  A61P43/00

    CPC classification number: A61K36/758 ,  A23L33/105

    Abstract: PROBLEM TO BE SOLVED: To provide a selective human β3 adrenalin receptor agonist agent derived from a safe food material, and a preventive and/or an improving agent for life style-related diseases such as fatness, obesity, diabetes, hyperlipemia, hypertension and gout containing the agonist agent. SOLUTION: This selective human β3 adrenalin receptor agonist agent comprises as the active ingredient a zanthoxylum extract obtained by extraction it with water, a water-soluble organic solvent or its mixed solvent. This selective human β3 adrenalin receptor agonist agent is useful as a preventive and/or an improving agent for life style-related diseases such as fatness, obesity, diabetes, hyperlipemia, hypertension and gout. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供来自安全食品材料的选择性人β3肾上腺素受体激动剂，以及用于生活方式相关疾病如肥胖，肥胖症，糖尿病，高脂血症的预防和/或改善剂， 含有激动剂的高血压和痛风。 解决方案：该选择性人β3肾上腺素受体激动剂包括通过用水，水溶性有机溶剂或其混合溶剂萃取而获得的花椒提取物作为活性成分。 该选择性人β3肾上腺素受体激动剂可用作生活方式相关疾病如肥胖，肥胖，糖尿病，高脂血症，高血压和痛风的预防和/或改善剂。 版权所有（C）2006，JPO＆NCIPI

    PPARγ LIGAND AGENT
    8.
    发明专利
    PPARγ LIGAND AGENT 审中-公开
    PPARgamma LIGAND代理

    公开(公告)号：JP2005097216A

    公开(公告)日：2005-04-14

    申请号：JP2003335477

    申请日：2003-09-26

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： NISHIYAMA TOZO ,  MAE TATSUMASA ,  KURODA AKIHIRA ,  MIMAKI YOSHIHIRO ,  SASHITA YUTAKA ,  KAWADA TERUO

    IPC: A61K31/56 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/565 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a peroxisome proliferator-activated receptor γ (PPARγ) ligand agent derived from a natural product; and to obtain a composition containing the agent as an active ingredient and having activities for preventing or ameliorating metabolic syndromes, insulin resistance, type 2 diabetes, hyperlipemia, hypertension, offal fat-type overweight and fatty liver.
    SOLUTION: This PPARγ ligand agent is dehydrodieugenol A, dehydrodieugenol B, magnolol, oleanolic acid, betulic acid or a salt thereof acceptable as a medicine or a food and drink. The composition containing the PPARγ ligand agent as an active ingredient is useful for preventing and ameliorating the metabolic syndrome, the insulin resistance, the type 2 diabetes, the hyperlipemia, the hypertension, the offal fat-type overweight and the fatty liver.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 待解决的问题：获得源自天然产物的过氧化物酶体增殖物激活受体γ（PPARγ）配体剂; 并获得含有该试剂作为活性成分并具有预防或改善代谢综合征，胰岛素抵抗，2型糖尿病，高脂血症，高血压，内脏脂肪型超重和脂肪肝的活性的组合物。 解决方案：该PPARγ配体试剂是可接受的药物或食品和饮料的脱氢丁子香酚A，脱氢丁子香酚B，厚朴酚，齐墩果酸，bet酸或其盐。 含有PPARγ配体剂作为活性成分的组合物可用于预防和改善代谢综合征，胰岛素抵抗，2型糖尿病，高脂血症，高血压，内脏脂肪型超重和脂肪肝。 版权所有（C）2005，JPO＆NCIPI

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