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    METHOD OF STABILIZING REDUCED COENZYME Q10 AND METHOD OF ACIDIC CRYSTALLIZATION
    2.
    发明公开
    METHOD OF STABILIZING REDUCED COENZYME Q10 AND METHOD OF ACIDIC CRYSTALLIZATION 有权
    方法稳定还原型辅酶Q10和方法酸性结晶

    公开(公告)号：EP1415973A4

    公开(公告)日：2006-02-01

    申请号：EP02746041

    申请日：2002-07-15

    Applicant: KANEKA CORP

    Inventor： UEDA TAKAHIRO ,  KITAMURA SHIRO ,  UEDA YASUYOSHI

    IPC: C07C41/40 ,  C07C41/46 ,  C07C43/23

    CPC classification number: C07C41/40 ,  C07C41/46 ,  C07C43/23

    Abstract: A method of efficiently producing reduced coenzyme Q 10 having excellent qualities which is useful in foods, foods with nutrient function claims, foods for specific health uses, nutritional supplements, tonics, animal drugs, drinks, feeds, cosmetics, drugs, remedies, preventives and so on. This method is suitable for industrial production thereof. Namely, reduced coenzyme Q 10 can be handled in a state of being protected from oxidation due to molecular oxygen by bringing the coenzyme Q 10 into contact with a solvent containing a strong acid. By crystallizing in the presence of a strong acid, moreover, coenzyme Q 10 can be converted into crystals while minimizing the formation of the oxidized coenzyme Q 10 as a by−product, thereby giving reduced coenzyme Q 10 having excellent qualities.

    REDUCED COENZYME Q10 CRYSTAL HAVING EXCELLENT STABILITY
    3.
    发明专利
    REDUCED COENZYME Q10 CRYSTAL HAVING EXCELLENT STABILITY 未知

    公开(公告)号：CA2837695C

    公开(公告)日：2019-12-31

    申请号：CA2837695

    申请日：2012-06-21

    Applicant: KANEKA CORP

    Inventor： KAWACHI HIDEO ,  KITAMURA SHIRO ,  UEDA YASUYOSHI

    IPC: C07C43/23 ,  A61K8/35 ,  A61K31/122 ,  A61P3/02 ,  C07C41/40

    Abstract: With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54 ~ 2°C during temperature rise at a rate of 5°C/min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2.theta. ~ 0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu-K.alpha.) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

    Método de purificación de coenzima-Q reducida
    4.
    发明专利
    Método de purificación de coenzima-Q reducida 未知

    公开(公告)号：ES2683000T3

    公开(公告)日：2018-09-24

    申请号：ES04701106

    申请日：2004-01-09

    Applicant: KANEKA CORP

    Inventor： UEDA TAKAHIRO ,  OHNO TADAO ,  KITAMURA SHIRO ,  UEDA YASUYOSHI

    IPC: C07C41/36 ,  C07C41/26 ,  C07C41/40 ,  C07C43/23

    Abstract: Método de purificación de coenzima Q10 reducida que puede obtenerse por reducción de coenzima Q10 oxidada, en el que se eliminan impurezas solubles en agua de la coenzima Q10 reducida, en el que el lavado de los cristales y/o el aceite de la coenzima Q10 reducida comprende poner en contacto cristales y/o aceite de la coenzima Q10 reducida con un disolvente orgánico soluble en agua o un disolvente mixto compuesto de un disolvente orgánico soluble en agua y agua en un recipiente y en el que el lavado de los cristales y/o el aceite de la coenzima Q10 reducida se lleva a cabo en un estado de dispersión de los cristales y/o el aceite de la coenzima Q10 reducida en el disolvente orgánico soluble en agua o el disolvente mixto compuesto del disolvente orgánico soluble en agua y agua y en el que los cristales y/o el aceite de la coenzima Q10 reducida se selecciona(n) del grupo que consiste en: cristales obtenibles mediante cristalización de o concentración hasta sequedad de una disolución que contiene coenzima Q10 reducida; un sólido que resulta de la solidificación de aceite de coenzima Q10 reducida; un aceite que resulta de la fusión de cristales de coenzima Q10 reducida; y un aceite obtenible concentrando una disolución que contiene coenzima Q10 reducida a una temperatura no inferior a la temperatura de fusión.

    Method of stabilizing reduced coenzyme Q10
    10.
    发明专利
    Method of stabilizing reduced coenzyme Q10 未知

    公开(公告)号：AU2002343962B2

    公开(公告)日：2008-01-24

    申请号：AU2002343962

    申请日：2002-10-10

    Applicant: KANEKA CORP

    Inventor： KITAMURA SHIRO ,  ONO TADAO ,  UEDA YASUYOSHI ,  UEDA TAKAHIRO ,  MORO MITSUTOSHI

    IPC: A61K31/122 ,  A61K47/12 ,  A61K47/22 ,  A61K47/34 ,  A61P3/02

    Abstract: Reduced coenzyme Q 10 is useful as functional nutritive foods, specific health foods and the like. The present invention provides a method for efficiently obtaining reduced coenzyme Q 10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q 10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q 10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q 10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q 10 as a byproduct is minimized by crystallizing reduced coenzyme Q 10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q 10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q 10 in the presence of ascorbic acid or a related compound thereof after reducing oxidized coenzyme Q 10 to reduced coenzyme Q 10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q 10 of high quality is produced.

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