公开(公告)号：AU2003268706A1

公开(公告)日：2004-04-23

申请号：AU2003268706

申请日：2003-10-01

Applicant: KANEKA CORP

Inventor： MARUOKA KEIJI ,  OOI TAKASHI ,  INOUE KENJI

IPC: B01J31/02 ,  B01J31/40 ,  C07D277/12 ,  B01J38/00 ,  C07C321/04 ,  C07C321/08

Abstract: The present invention provides a simple, practical, and industrially advantageous process for producing an optically active alpha -substituted cysteine or a salt thereof from inexpensive and readily available materials. The present invention provides a process for producing an optically active alpha -substituted cysteine or a salt thereof by converting a cysteine derivative into a thiazoline compound and subjecting the resulting thiazoline compound to a stereoselective substituent-introducing reaction catalyzed by an optically active quaternary ammonium salt, in particular, an axially asymmetric quaternary ammonium salt to produce an optically active thiazoline compound and then hydrolyzing the resulting thiazoline compound.

公开(公告)号：EP1548013A4

公开(公告)日：2006-07-12

申请号：EP03748633

申请日：2003-10-01

Applicant: KANEKA CORP

Inventor： MARUOKA KEIJI ,  OOI TAKASHI ,  INOUE KENJI

IPC: B01J31/02 ,  B01J31/40 ,  B01J38/00 ,  C07C321/04 ,  C07C321/08 ,  C07D277/12

CPC classification number: B01J31/0239 ,  B01J31/40 ,  C07B2200/07 ,  C07C319/02 ,  C07D277/12 ,  Y02P20/584 ,  C07C323/58

Abstract: A practical process for easily or industrially advantageously producing from an easily available inexpensive material an optically active α-substituted cysteine or salt thereof useful as an intermediate for medicines, etc. The process, which is for producing an optically active α-substituted cysteine or salt thereof, comprises converting a cysteine derivative into a thiazoline compound, subjecting the compound to a stereoselective substituent-introducing reaction with the aid of an optically active quaternary ammonium salt, especially an axially asymmetric quaternary ammonium salt, as a catalyst to thereby obtain an optically active thiazoline compound, and hydrolyzing it.