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公开(公告)号：JPS61103833A
公开(公告)日：1986-05-22
申请号：JP22505684
申请日：1984-10-25
Applicant: Kao Corp
Inventor： FUTAMI TAKAHIRO , MASUDA SHINICHI , TAKAISHI NAOTAKE
Abstract: PURPOSE: The titled promoter comprising an extract of root of umbelliferous plant as an active ingredient.
CONSTITUTION: Root of umbelliferous plant (e.g., ANMI, Anethum L., YOROI GUSA, Peucedanum decursivum Maxim., UDOMODOKI, Angelica keiskei Koidz, Angelica polyclada Franch., Lingusticum acutilobum Sieb. et Zuce., etc.) is optionally gorund or crushed, and extractd with a polar or nonpolar organic solvent or a mixed solvent of two or more of them, or a mixed solvent of the organic solvent and water at room temperature or under heating. the pre pared extracted solution is directly used as an active ingredient, or concentrated or the solvent is distilled away, the extracted solution is made into dryness, and used as the active ingredient. A promoter for skin blood circulation for external use containing 0.01W50wt%, preferably 1W10wt% active ingredient is obtained. It is applied locally to the affected part for keeping health of the skin, preventing regressive change, nourishing hair, growing hair, preventing gingivitis. It is also applied as a suppository, etc., shows remedying effects on hemorrhoids.
COPYRIGHT: (C)1986,JPO&JapioAbstract translation: 目的：标题促进剂，其包含伞形植物根的提取物作为活性成分。 构成：伞形植物的根（例如，ANMI，Anethum L.，YOROI GUSA，Peucedanum decursivum Maxim。，UDOMODOKI，Angelica keiskei Koidz，Angelica polyclada Franch。，Lingusticum acutilobum Sieb。et Zuce等）任选地被磨碎或粉碎 用极性或非极性有机溶剂或它们中的两种或更多种的混合溶剂或有机溶剂和水的混合溶剂在室温或加热下萃取。 直接提取的溶液直接用作活性成分，或浓缩或蒸馏除去溶剂，将提取的溶液干燥，并用作活性成分。 获得含有0.01-50重量％，优选1-10重量％活性成分的外用皮肤血液循环促进剂。 将其局部应用于受影响的部位，以保持皮肤的健康，防止回归变化，滋养头发，生长头发，预防牙龈炎。 也适用于栓剂等，显示对痔疮的补救作用。
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公开(公告)号：JPS6089426A
公开(公告)日：1985-05-20
申请号：JP19875483
申请日：1983-10-24
Applicant: KAO CORP
Inventor： TAKANO SATOSHI , FUTAMI TAKAHIRO
Abstract: PURPOSE:To provide a rapid and long-acting, low-toxic cardiotonic agent, containing the extract of the root of a Cirsium genus plant with water or a polar organic solvent, as an active component. CONSTITUTION:The root of a plant belonging to Cirsium genus is cut or crushed to fine pieces, and extracted with water or a polar organic solvent (e.g. methanol, ethanol, etc.). The extract is optionally concentrated, dried, or purified to obtain the objective cardiotonic agent. The Cirsium genus plant is preferably Cirsium dipsacolepis (Maxim.) Matsum. The cardiotonic effect of the agent develops rapidly and lasts long. The rapid activity and the hypotensive action of the drug are similar to those of l-isoproterenol hydrochloride, and the drug is inert to the blood pressure and pulse rate. The action is different from the slow- acting G-strophanthin. The extract has been served as a food, and has extremely low toxicity.
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公开(公告)号：JPS6172717A
公开(公告)日：1986-04-14
申请号：JP19552184
申请日：1984-09-18
Applicant: Kao Corp
Inventor： FUTAMI TAKAHIRO , MASUDA SHINICHI , TAKANO SATOSHI , TAKAISHI NAOTAKE , HARA KENJI
Abstract: PURPOSE: To provide the titled promoting agent containing a specific unsaturated fatty acid or its ester as an active component.
CONSTITUTION: The objective peripheral circulation promoting agent can be prepared by using a 8W24C unsaturated fatty acid having 1W3 C=C double bonds, or its ester (e.g. linoleic acide, linolenic acid, linolenic acid monoglyceride, etc.) as an active component, and adding an antioxidation agent (e.g. dl-α- tocopherol, nordihydroguaiaretic acid, extract of herb having antioxidation activity, etc.) to improve the effect of the unsaturated fatty acid. It is administered by oral administration, injection (intravenous, subcutaneous or intramuscular injection), external application, or in the form of suppository, etc., especially preferably by external application. Dose: preferably 0.1W1,000mg/kg daily for oral administration, and 0.01W1,000mg/kg daily for injection. In the case of external drug, a proper amount of a composition containing 0.01W10wt% active component is applied locally to the diseased part at a proper time.
COPYRIGHT: (C)1986,JPO&JapioAbstract translation: 目的：提供含有特定不饱和脂肪酸或其酯作为活性成分的标题促进剂。 构成：可以通过使用具有1-3个C = C双键的8-24C不饱和脂肪酸或其酯（例如亚油酸，亚麻酸，亚麻酸单甘油酯等）来制备目标的外周循环促进剂作为 活性成分，添加抗氧化剂（例如dl-α-生育酚，去甲二氢愈创木酸，具有抗氧化活性的草药提取物等），以改善不饱和脂肪酸的作用。 其通过口服给药，静脉内，皮下或肌内注射，外用或栓剂形式等，特别优选通过外用施用。 剂量：口服给药每日优选0.1-1,000mg / kg，每日注射0.01-1,000mg / kg。 在外用药物的情况下，适当时间将适量的含有0.01-10重量％活性成分的组合物局部施用于患病部位。
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公开(公告)号：JPS6165892A
公开(公告)日：1986-04-04
申请号：JP18720884
申请日：1984-09-06
Applicant: Kao Corp
Inventor： FUTAMI TAKAHIRO , ICHII YUJI , KAWAMATA AKIRA , URATA KOICHI , TAKAISHI NAOTAKE
IPC: A61K31/675 , A61P29/00 , C07F9/22 , C07F9/24 , C07F9/6584
Abstract: NEW MATERIAL:A compound of formula I (R
1 is 1W25C alkyl; R
2 is 1W6C alkyl; R
3 is 1W6C alkyl, H, aralkyl; A is 1W6C alkylene).
EXAMPLE: The compound of formula II.
USE: Nonsteroidal anti-inflammatory, remedy for hemorrhoids. It has very low toxicity with reduced irritation.
PREPARATION: For example, a glycerol dialkyl ether of formula III is allowed to react with phosphorus oxychloride in the presence of triethylamine and the resultant compound of formula IV is allowed to react with an amine of formula V such as N-methylethanolamine in the presence of triethylamine.
COPYRIGHT: (C)1986,JPO&JapioAbstract translation: 新物质：式I化合物（R 1为1-25C烷基; R 2为1-6C烷基; R 3为1-6C烷基，H为芳烷基; A为1-6C亚烷基） 。 实施例：式II化合物。 用途：非甾体抗炎，痔疮补救。 它具有非常低的毒性，刺激性降低。 制备：例如，使式III的甘油二烷基醚在三乙胺存在下与三氯氧化磷反应，并使得到的式IV化合物与式V的胺如N-甲基乙醇胺在存在下反应 三乙胺
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公开(公告)号：JPS6163617A
公开(公告)日：1986-04-01
申请号：JP18589084
申请日：1984-09-05
Applicant: Kao Corp
Inventor： FUTAMI TAKAHIRO , ICHII YUJI , KAWAMATA AKIRA , URATA KOICHI , TAKAISHI NAOTAKE
IPC: A61K31/665 , A61P29/00
Abstract: PURPOSE: An anti-inflammatory drug having extremely low toxicity, containing a dioxaphosphorane derivative as an active ingredient.
CONSTITUTION: An anti-inflammatory drug containing a compound (e.g., compound shown by the formula II, etc.) shown by the formula I (R
1 is 1W25C straight-chain or branched alkyl; R
2 is 1W6C straight-chain or branched alkyl; A is 1W6C alkylene) as an active ingredient. Oral administration, injection, external preparation, suppository, etc. may be used as administration method. A dose is 0.1W1,000mg/kg/day in the case of oral administration, and preferably 0.01W1,000mg/kg/day in the case of injection. In the case of external preparation, a proper amount of external preparation containing 0.01W10wt% compound shown by the formula I is locally applied to the affected part. In the case of suppository, addition of another anti-inflammatory drug, various natural extracts, etc., to suppository can raise anti-inflammatory effects, and usable further as a remedy for hemorrhoids.
COPYRIGHT: (C)1986,JPO&JapioAbstract translation: 目的：具有极低毒性的抗炎药，含有二氧磷杂环硼烷衍生物作为活性成分。 构成：含有式I所示的化合物（例如由式II等所示的化合物）的抗炎药物（R 1）为1-25C直链或支链烷基; R 2为1 -6C直链或支链烷基; A为1-6C亚烷基）作为活性成分。 口服给药，注射剂，外用剂，栓剂等可用作给药方法。 在口服给药的情况下，剂量为0.1-1,000mg / kg /天，在注射的情况下优选为0.01-1,000mg / kg /天。 在外用制剂的情况下，将局部施用含有0.01〜10wt％式I化合物的适量的外用制剂局部施用于患部。 在栓剂的情况下，向栓剂中添加另一种抗炎药，各种天然提取物等可以提高抗炎作用，并可用作痔疮的补救剂。
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Patent Agency Ranking
公开(公告)号：JPS60239419A
公开(公告)日：1985-11-28
申请号：JP9626684
申请日：1984-05-14
Applicant: KAO CORP
Inventor： FUTAMI TAKAHIRO , TAKAISHI NAOTAKE , URATA KOUICHI
IPC: A61K8/67 , A61K31/365 , A61P9/00 , A61P17/00 , A61Q11/00
Abstract: PURPOSE:To provide a peripheral circulation promoting agent for external use, containing a specific ascorbic acid derivative as an active component, exhibiting dermatic blood-flow promoting effect at a low concentration, free from side effects to the skin, and effective to the maintenance of the health of the skin, hair growth, prevention of gingivitis, etc. CONSTITUTION:The objective agent contains the ascorbic acid derivative of formula (at least one of R1-4 is 1-20C alkyl, alkenyl, etc., and the others are H) as an active component. It has been found that when the compound of formula is applied topically, dermatic blood-flow can be promoted at an extremely low concentration without causing side effects such as stimulation, allergic reaction, or burning sensation of the skin, and the compound can be maintained stably for a long period. It does not influence the skin temperature, and dilates the blood vessel by the direct action to the smooth muscle of the vessel. It is applied topically for the maintenance of the health of the skin, the prevention of retroplasia, the growth and nonrishment of the hair, and the prevention of gingivitis, etc.
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公开(公告)号：JPH0369330B2
公开(公告)日：1991-10-31
申请号：JP19875483
申请日：1983-10-24
Applicant: KAO CORP
Inventor： TAKANO SATOSHI , FUTAMI TAKAHIRO
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公开(公告)号：JPS61291516A
公开(公告)日：1986-12-22
申请号：JP13472585
申请日：1985-06-20
Applicant: KAO CORP
Inventor： FUTAMI TAKAHIRO , TSUJITA SATOSHI , EGUCHI YASUTERU
Abstract: PURPOSE:To provide an agent for dyeing sordes on tooth by using a dye for sordes on tooth in combination with a binder and/or a surfactant. CONSTITUTION:The objective agent for dyeing sordes on tooth contains (A) 0.5-3w/v% dye for sordes on tooth (e.g. amaranth, erythrocin, neucoccin, chlorophyll pigment, methylene blue, etc.) and (B) 0.01-1w/v% binder (e.g. agar, sodium alginate, starch paste, gelatin, gum, wax, etc.) and/or 0.05-2w/v% surfactant (e.g. water-soluble salt of alkylsulfuric acid ester such as sodium laurate, etc., water-soluble salt of monoalkylphosphoric acid ester such as sodium monolaurylphosphate, etc., water-soluble salt of N-acylamino aid such as sodium N-lauroylsarcosine, etc.). EFFECT:Sordes on tooth can be dyed with the agent clearly and uniformly without degrading the appearance of the tooth. Since a swab containing said agent rapidly absorbs a large amount of water, the state of adhering sordes on tooth can be observed easily after the application of the agent.
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公开(公告)号：JPS5350337A
公开(公告)日：1978-05-08
申请号：JP12329676
申请日：1976-10-14
Applicant: KAO CORP
Inventor： FUTAMI TAKAHIRO , YOROZU HIDENORI , MASUDA FUMIHACHI
Abstract: PURPOSE:To prepare CNS-type emetics containing 3-amino-4homoisotwistane salt as a main component, having emetic activity without side effects.
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公开(公告)号：JPS5350336A
公开(公告)日：1978-05-08
申请号：JP12329576
申请日：1976-10-14
Applicant: KAO CORP
Inventor： FUTAMI TAKAHIRO , YOROZU HIDENORI , MASUDA FUMIHACHI
Abstract: PURPOSE:To prepare antidepressants containing 3-amino-4-homoisotwistane salt having excellent antideprerrant activity without side effects to automomic nervous system and peripheral organs.
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