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公开(公告)号：EP1797858A4
公开(公告)日：2009-03-11
申请号：EP05787958
申请日：2005-09-28
Applicant: KAO CORP
Inventor： ITANO MORIHIDE , KAYANE SHIGETO , UENO KATSUYA , MIZUSHIMA HIROMOTO
IPC: A61K8/34 , A61K8/39 , A61K8/73 , A61K31/7028 , A61K31/7032 , A61P1/02 , A61Q11/00
CPC classification number: A61Q17/005 , A61K8/34 , A61K8/39 , A61K8/602 , A61K8/604 , A61K8/608 , A61K8/73 , A61K31/7028 , A61K31/7032 , A61Q11/00
Abstract: A composition for oral cavity which contains a compound represented by the formula (A) (wherein R represents optionally substituted, C 6-18 , linear or branched alkyl; G represents a galactose residue; m is an integer of 0-200; and n is an integer of 1-30); and an inhibitor for the co-coagulation of fusobacterium bacteria and cariogenic bacteria which contains the compound as an active ingredient. The composition for oral cavity inhibits the co-coagulation of fusobacterium bacteria and cariogenic bacteria and is highly effective in preventing teeth from decaying.
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公开(公告)号：EP3090728A4
公开(公告)日：2017-08-09
申请号：EP13900001
申请日：2013-12-27
Applicant: KAO CORP
Inventor： OGIHARA AYA , ITANO MORIHIDE
IPC: A61K8/60 , A61K8/41 , A61K8/43 , A61K8/49 , A61K9/00 , A61K9/08 , A61K31/4425 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/26 , A61K47/44 , A61Q11/00
CPC classification number: A61K8/604 , A61K8/416 , A61K8/43 , A61K8/4926 , A61K8/60 , A61K8/922 , A61K9/0053 , A61K9/08 , A61K31/4425 , A61K31/7028 , A61K47/10 , A61K47/14 , A61K47/186 , A61K47/26 , A61K47/32 , A61K47/44 , A61K2800/592 , A61Q11/00 , C07H15/04 , A61K2300/00
Abstract: The present invention relates to an oral composition having an enhanced solubility of an alkyl galactoside while holding an inhibiting effect on coaggregation of the alkyl galactoside well. The present invention provides an oral composition comprising the following components: (A) 0.001 mass% or more and 1 mass% or less of a compound represented by the following formula (I): wherein R is an optionally substituted linear or branched alkyl group having 8 to 18 carbon atoms, G is a galactose residue, E is a hydrogen atom or a methyl group, m is an integer of 0 to 200, and n is an integer of 1 to 30; (B) 0.001 mass% or more and 0.1 mass% or less of a cationic bactericide; and (C) 35 mass% or more of water.
Abstract translation: 本发明涉及一种口服组合物，其具有增强的烷基半乳糖苷溶解度，同时对烷基半乳糖苷的共聚集作用具有良好的抑制作用。 本发明提供含有下述成分的口腔用组合物：（A）下述式（I）所示的化合物0.001质量％以上1质量％以下，其中，R为可以具有取代基的直链状或支链状的烷基， 碳原子数8〜18，G为半乳糖残基，E为氢原子或甲基，m为0〜200的整数，n为1〜30的整数。 （B）阳离子性杀菌剂为0.001质量％以上且0.1质量％以下， 和（C）35质量％以上的水。
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公开(公告)号：JP2007291083A
公开(公告)日：2007-11-08
申请号：JP2007083232
申请日：2007-03-28
Inventor： ITANO MORIHIDE , UENO KATSUYA , KUBOTA HIROMI
Abstract: PROBLEM TO BE SOLVED: To inexpensively provide an oral composition that exhibits strong suppressive actions on co-aggregation of bacteria of the genus Fusobacterium with cariogenic bacteria or periodontal disease-related bacteria and sterilizes bacteria of the genus Fusobacterium specifically thereby preventing plaque formation and dental caries or periodontal diseases.
SOLUTION: The oral composition comprises a compound represented by formula (A) (wherein R is an optionally substituted 6-16C linear or branched alkyl group; G is a galactose residue; E is a hydrogen atom or a methyl group; m is an integer of 0-200; and n is an integer of 1-30) and a nonionic bactericide.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 要解决的问题：为了廉价地提供一种口服组合物，其对于与致龋细菌或牙周疾病相关的细菌的细菌共同聚集具有强烈的抑制作用，并且特异性地灭菌Fusobacterium属的细菌，从而防止斑块形成 龋齿或牙周病。 口服组合物包含由式（A）表示的化合物（其中R是任选取代的6-16C直链或支链烷基; G是半乳糖残基; E是氢原子或甲基; m 为0〜200的整数，n为1-30的整数）和非离子性杀菌剂。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2004321498A
公开(公告)日：2004-11-18
申请号：JP2003120577
申请日：2003-04-24
Inventor： YAMASHIRO TAKAHISA , ITANO MORIHIDE , KAYANE SHIGETO
IPC: A61C17/00 , A61C19/06 , A61K31/05 , A61K31/055 , A61K31/14 , A61K31/155 , A61K31/197 , A61K31/223 , A61K31/355 , A61K31/375 , A61K31/4166 , A61K31/4427 , A61K31/4709 , A61K31/575 , A61K31/704 , A61K33/20 , A61K36/00 , A61K38/46 , A61P29/00 , A61P31/04 , A61K35/78
CPC classification number: A61C17/228
Abstract: PROBLEM TO BE SOLVED: To provide a device for improving an oral environment capable of minimizing stimulation to an oral mucous membrane by a sterilizer or the like and easily and surely performing the prevention of dental caries and the treatment of a periodontal disease, etc., by localizing a composition including the sterilizer or the like on a tooth surface and a periodontal part. SOLUTION: The device 10 for improving the oral environment is provided with a tray 12 for an oral cavity capable of filling the composition 11 whose viscosity at 25°C is 0.1 to 1,000 Pa×s, a vibrator 13 for vibrating the tray 12, and a vibration source 14 for supplying vibrations to the vibrator 13. The vibration frequency of the tray is 1 Hz to 10 kHz. Also, it is preferable that the composition 11 contains the sterilizer composed of benzethonium chloride, benzalkonium chloride and cetylpyridinium chloride, etc., and anti-inflammatory components composed of allantoins, glycyrrhizinic acid, β-glycyrrhizinic acid, dihydrocholesterol, ε-amino capric acid, ascorbic acid, tocopherols and various kinds of vegetable extracts, etc. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 要解决的问题：提供一种能够通过灭菌器等来最小化对口腔粘膜的刺激的口腔环境改善装置，并且容易且可靠地进行预防龋齿和牙周病的治疗， 通过将包含灭菌器等的组合物定位在牙齿表面和牙周部上。 解决方案：用于改善口腔环境的装置10设置有用于口腔的托盘12，其能够填充其粘度在25℃下为0.1至1,000Pa×s的组合物11，振动器13用于振动托盘 12和用于向振动器13提供振动的振动源14.托盘的振动频率为1Hz至10kHz。 此外，组合物11优选含有由苄索氯铵，苯扎氯铵和氯化十六烷基吡啶等组成的消毒剂，由尿嘧啶，甘草酸，β-甘草酸，二氢胆固醇，ε-氨基癸酸 ，抗坏血酸，生育酚和各种植物提取物等。版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：JP2008032531A
公开(公告)日：2008-02-14
申请号：JP2006206212
申请日：2006-07-28
Inventor： YOSHIDA OSAMU , ITANO MORIHIDE
IPC: G01N23/225 , H01J37/20
Abstract: PROBLEM TO BE SOLVED: To provide an evaluation method of the co-flocculation capacity of bacteria capable of objectively and easily evaluating the co-flocculation capacity of bacteria.
SOLUTION: In the evaluation method of the co-flocculation capacity of bacteria, external force is applied to a capsule 11 for submerged observation containing at least two kinds of bacteria becoming an evaluation target, the co-flocculation states of bacteria before and after external force is applied is observed by a scanning electron microscope and the co-flocculation capacity of bacteria is evaluated on the basis of the observation result. It is preferable to apply the external force to the capsule 11 for submerged observation in the scanning electron microscope and the external force is preferably applied to the capsule 11 for submerged observation while vibrating the capsule.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 要解决的问题：提供能够客观容易地评价细菌共絮凝能力的细菌的共絮凝能力的评价方法。 解决方案：在细菌共絮凝能力的评价方法中，将外力施加到用于淹没观察的胶囊11中，其中含有至少两种细菌成为评价对象，前述细菌的共絮凝状态 通过扫描电子显微镜观察施加外力后，根据观察结果评价细菌的共絮凝能力。 优选在扫描电子显微镜中将外力施加到胶囊11进行浸没观察，并且在振动胶囊的同时优选将外力施加到胶囊11进行淹没观察。 版权所有（C）2008，JPO＆INPIT
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Patent Agency Ranking6.发明专利
公开(公告)号：JP2004201679A
公开(公告)日：2004-07-22
申请号：JP2003403715
申请日：2003-12-02
Inventor： IWASE TADAYUKI , ITANO MORIHIDE , YANO YOSHITAKA
CPC classification number: C12Q1/689
Abstract: PROBLEM TO BE SOLVED: To provide a method for specifically detecting Fusobacterium nucleatum which is a suppurative disease-related bacterium and a mouth odor-causing bacterium in a biological sample.
SOLUTION: In this method for examining and/or quantitatively analyzing the bacterium by a PCR process, primers (1) and (2) are used. The primer (1) comprises a forward primer which has a base sequence comprising a part of a specified base sequence and having 10 or more base units, and the primer (2) comprises a reverse primer which has another base sequence comprising a part of the other base sequence complementary to another specified base sequence and having 10 or more base units are included as the primers.
COPYRIGHT: (C)2004,JPO&NCIPI-
公开(公告)号：JPH09140392A
公开(公告)日：1997-06-03
申请号：JP30430995
申请日：1995-11-22
Applicant: KAO CORP
Inventor： HONDA YASUKI , ITANO MORIHIDE
Abstract: PROBLEM TO BE SOLVED: To efficiently obtain a polysaccharide improved in productivity, useful as a thickening agent, a gelling agent, an emulsion stabilizer, etc., by culturing a plant cell such as a callus of a plant of the genus Polyanthus, adding a carbon source to a medium during the culture, capable of proliferating a large amount of the plant cell. SOLUTION: A flower bud of a plant belonging to the genus Polyanthus (e.g. tuberose) is cut out, sterilized, washed with sterilized water, cut into a proper size, laid as an explant on a callus inducing medium, cultured at 25 deg.C for 30 days and induced into a callus. Then the callus is inoculated into a liquid medium and subjected to shaking culture. In the middle of the culture on the 14th day of the culture, one or more of a monosaccharide (e.g. glucose) and a disaccharide (e.g. saccharose) are added as a carbon source to a medium and the callus is successively cultured until the 28th day to give a polysaccharide which is capable of proliferating a large amount of a plant cell and is useful as a thickening agent, a gelling agent, a foam stabilizer, a suspension/emulsion stabilizer, a film-forming agent, a tacky agent, a physiological activator, etc.
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公开(公告)号：JP2009161447A
公开(公告)日：2009-07-23
申请号：JP2007339643
申请日：2007-12-28
Inventor： ITANO MORIHIDE , KASHIWAGI MITSUYOSHI
IPC: A61K8/34 , A61K8/35 , A61K8/37 , A61K8/60 , A61K31/045 , A61K31/11 , A61K47/14 , A61K47/36 , A61P1/02 , A61P43/00 , A61Q11/00
Abstract: PROBLEM TO BE SOLVED: To provide a composition for oral cavities, which promotes the secretion of IgA antibody in saliva and is excellent in an effect for preventing the formation of biofilms causing oral cavity diseases.
SOLUTION: Provided are an agent for promoting the secretion of IgA in saliva, comprising (A) an aroma compound selected from cinnamic alcohol and perilla aldehyde, and (B) a nonionic surfactant selected from sucrose fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters; and the composition for the oral cavities.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 要解决的问题：提供一种口腔用组合物，其促进唾液中IgA抗体的分泌，并且具有优异的防止形成引起口腔疾病的生物膜的效果。 提供了用于促进唾液中IgA分泌的试剂，其包含（A）选自肉桂醇和紫苏醛的芳香化合物，和（B）非离子表面活性剂，其选自蔗糖脂肪酸酯，脱水山梨糖醇脂肪酸 酯和聚氧乙烯山梨糖醇酐脂肪酸酯; 和口腔组合物。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2009091285A
公开(公告)日：2009-04-30
申请号：JP2007262109
申请日：2007-10-05
Inventor： ITANO MORIHIDE , UENO KATSUYA , MIZUSHIMA YOUSEN
Abstract: PROBLEM TO BE SOLVED: To provide a liquid oral composition stably compounded without damaging the effect of inhibiting the coaggregation of an alkylgalactoside.
SOLUTION: The oral composition comprises a compound represented by formula (A) (wherein R
1 is a 10-16C straight-chain or branched-chain alkyl group which may be substituted; Gal is a galactose residue; and n is an integer of 1-10) and a compound represented by formula (B) (wherein R
2 is a 6-16C straight-chain or branched-chain alkyl group which may be substituted; Glc is a glucose residue; and m is a number of 1-30).
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 待解决的问题：提供稳定配合的液体口服组合物，而不损害抑制烷基半乳糖苷共聚的作用。 口服组合物包含由式（A）表示的化合物（其中R
1 是可被取代的10-16C直链或支链烷基; Gal是 半乳糖残基; n为1-10的整数）和由式（B）表示的化合物（其中R 2 是6-16C直链或支链烷基，其可以是 取代的; Glc是葡萄糖残基; m是1-30的数）。 版权所有（C）2009，JPO＆INPIT -
公开(公告)号：JP2007291085A
公开(公告)日：2007-11-08
申请号：JP2007083234
申请日：2007-03-28
Inventor： ITANO MORIHIDE , YANO YOSHITAKA
IPC: A61K8/67 , A61K8/34 , A61K8/60 , A61K8/73 , A61K31/355 , A61K47/10 , A61K47/26 , A61K47/36 , A61P1/02 , A61Q11/00
Abstract: PROBLEM TO BE SOLVED: To provide an oral composition that improves stability of vitamin E or a derivative thereof and exhibits highly preventive effects on dental caries or periodontal diseases.
SOLUTION: The oral composition comprises Vitamin E or a derivative thereof and a compound represented by formula (A) (wherein R is an optionally substituted 6-16C linear or branched alkyl group; G is a galactose residue; E is a hydrogen atom or a methyl group; m is an integer of 0-200; and n is an integer of 1-30).
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 待解决的问题：提供改善维生素E或其衍生物的稳定性的口腔组合物，并且对龋齿或牙周病具有高度预防效果。 口服组合物包含维生素E或其衍生物和由式（A）表示的化合物（其中R是任选取代的6-16C直链或支链烷基; G是半乳糖残基; E是氢 原子或甲基; m为0〜200的整数，n为1-30的整数）。 版权所有（C）2008，JPO＆INPIT
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