公开(公告)号：US09815935B2

公开(公告)日：2017-11-14

申请号：US14783892

申请日：2014-04-14

Applicant: KENT STATE UNIVERSITY

Inventor： Elda Hegmann ,  Torsten Hegmann ,  Anshul Sharma ,  Abdollah Neshat

IPC: A61L27/56 ,  C08G63/91 ,  A61L27/58 ,  C08G63/08 ,  C09K19/38 ,  A61L27/18 ,  A61L31/06

CPC classification number: C08G63/916 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/06 ,  C08G63/08 ,  C09K19/3866 ,  C08L67/04

Abstract: Controlled biodegradable smart responsive scaffold (SRS) materials enhance attachment and viability of cells, i.e. actively guiding their expansion, proliferation and in some cases differentiation, while increasing their biomechanical functionality is an important key issue for tissue regeneration. Chemically build-in functionality in these biodegradable SRS materials is achieved by varying structural functionalization with biocompatible liquid crystal motifs and general polymer composition allowing for regulation and alteration of tensile strength, surface ordering, bioadhesion and biodegradability, bulk liquid crystal phase behavior, porosity, and cell response to external stimuli. Liquid crystal modification of such polymeric scaffolds is an ideal tool to induce macroscopic ordering events through external stimuli. None of these approaches have been demonstrated in prior art, and the use of biocompatible scaffolds that respond to a variety of external stimuli resulting in a macroscopic ordering event is a novel aspect of the present invention.

公开(公告)号：US10563012B2

公开(公告)日：2020-02-18

申请号：US15805510

申请日：2017-11-07

Applicant: KENT STATE UNIVERSITY

Inventor： Elda Hegmann ,  Torsten Hegmann ,  Anshul Sharma ,  Abdollah Neshat

IPC: A61L27/56 ,  C08G63/91 ,  A61L27/58 ,  A61L27/18 ,  C08G63/08 ,  C09K19/38 ,  A61L31/06

Abstract: Controlled biodegradable smart responsive scaffold (SRS) materials enhance attachment and viability of cells, i.e. actively guiding their expansion, proliferation and in some cases differentiation, while increasing their biomechanical functionality is an important key issue for tissue regeneration. Chemically build-in functionality in these biodegradable SRS materials is achieved by varying structural functionalization with biocompatible liquid crystal motifs and general polymer composition allowing for regulation and alteration of tensile strength, surface ordering, bioadhesion and biodegradability, bulk liquid crystal phase behavior, porosity, and cell response to external stimuli. Liquid crystal modification of such polymeric scaffolds is an ideal tool to induce macroscopic ordering events through external stimuli. None of these approaches have been demonstrated in prior art, and the use of biocompatible scaffolds that respond to a variety of external stimuli resulting in a macroscopic ordering event is a novel aspect of the present invention.