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    SYSTEM FOR PROVIDING A METHOD FOR APPLYING A SKIN SEALANT HAVING A PHASE CHANGE VISUAL INDICATING COMPONENT
    1.
    发明申请
    SYSTEM FOR PROVIDING A METHOD FOR APPLYING A SKIN SEALANT HAVING A PHASE CHANGE VISUAL INDICATING COMPONENT 审中-公开
    提供具有相变视觉指示组件的皮肤密封剂的方法的系统

    公开(公告)号：WO2009047663A2

    公开(公告)日：2009-04-16

    申请号：PCT/IB2008053779

    申请日：2008-09-17

    Applicant: KIMBERLY CLARK CO ,  MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    Inventor： MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    IPC: A61M35/00

    CPC classification number: A61M35/003 ,  A61B2017/00495

    Abstract: A system for providing a method of sealing skin with a film forming polymer is provided. The system includes providing an at least two part applicator containing a sealant composition in one or more frangible containers, providing instructions for using the applicator associated therewith, where the method including moving at least one of said applicator parts from a first position to a second position and applying said sealant to skin. The composition has film former, a plasticizer and 3000 to 10000 ppm of a dye that changes color when is undergoes a phase change. The color change is visible to a human eye under normal light conditions. changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.

    Abstract translation: 提供了一种用于提供用成膜聚合物密封皮肤的方法的系统。 该系统包括在一个或多个易碎容器中提供含有密封剂组合物的至少两个部分施用器，其提供使用与其相关联的施用器的指导，其中所述方法包括将所述施用器部件中的至少一个从第一位置移动到第二位置 并将所述密封剂施加到皮肤上。 该组合物具有成膜剂，增塑剂和3000至10000ppm的染料，当发生相变时颜色变化。 在正常光照条件下，人眼可见颜色变化。 可以使用改变的染料来表示组合物已经干燥。 染料根据相变而变色，即成膜剂的干燥。 染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。 可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

    PHASE CHANGE VISUAL INDICATING COMPOSITION
    3.
    发明申请
    PHASE CHANGE VISUAL INDICATING COMPOSITION 审中-公开
    相变视觉指示组合物

    公开(公告)号：WO2009047655A3

    公开(公告)日：2009-05-28

    申请号：PCT/IB2008052825

    申请日：2008-07-14

    Applicant: KIMBERLY CLARK CO ,  MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    Inventor： MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    IPC: A61K8/00 ,  A61K49/00 ,  C12Q1/04

    CPC classification number: A61K33/18 ,  A61L26/0061 ,  A61L26/0066 ,  A61L26/0071 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/442

    Abstract: A skin sealant composition of a film former and a plasticizer and having various color changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.

    Abstract translation: 可以使用成膜剂和增塑剂并具有各种变色染料的皮肤密封剂组合物来表示组合物已经干燥。 染料根据相变而变色，即成膜剂的干燥。 染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。 可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

    COLOR CHANGING SKIN SEALANT
    4.
    发明申请
    COLOR CHANGING SKIN SEALANT 审中-公开
    颜色变化的皮肤密封剂

    公开(公告)号：WO2008032231A3

    公开(公告)日：2008-09-25

    申请号：PCT/IB2007053274

    申请日：2007-08-16

    Applicant: KIMBERLY CLARK CO ,  MACDONALD JOHN GAVIN ,  AREHART KELLY ,  SMITH MOLLY K ,  WEART ILONA FURMAN ,  SCHORR PHILLIP A

    Inventor： MACDONALD JOHN GAVIN ,  AREHART KELLY ,  SMITH MOLLY K ,  WEART ILONA FURMAN ,  SCHORR PHILLIP A

    IPC: A61L24/00

    CPC classification number: A61L24/001

    Abstract: Iodine is used in about 80 percent of surgeries in the US to remove some level of microbial load on the skin prior to making an incision. Skin sealants are applied over skin preps to seal the skin and hold any remaining bacteria in place. Iodine produces a characteristic orange-brown color on skin. A skin sealant is provided that has a decolorant that reacts with the iodine found in most skin preps, rendering the skin prep colorless. A skin sealant containing ascorbic acid (vitamin C), Indigo Carmine or Indigo will react with the iodine, thus visually indicating where the skin prep and sealant have been applied and allowing an unobstructed view of the incision.

    Abstract translation: 在美国约80％的手术中使用碘，以在切开前去除皮肤上的一定程度的微生物负荷。 将皮肤密封剂涂于皮肤上，以密封皮肤并将任何残留的细菌保持在适当的位置。 碘在皮肤上产生特征橙棕色。 提供具有与大多数皮肤前食中发现的碘反应的脱色剂的皮肤密封剂，使得皮肤无色。 含有抗坏血酸（维生素C），靛蓝胭脂红或靛蓝的皮肤密封剂将与碘反应，从而可视地显示出皮肤制剂和密封剂的使用位置，并允许切口无阻碍地观察。

    SKIN PREPARATION THAT IMMOBILIZES BACTERIA
    5.
    发明申请
    SKIN PREPARATION THAT IMMOBILIZES BACTERIA 审中-公开
    皮肤准备，可以固定细菌

    公开(公告)号：WO2011077281A3

    公开(公告)日：2011-11-17

    申请号：PCT/IB2010055330

    申请日：2010-11-22

    Applicant: KIMBERLY CLARK CO ,  SCHORR PHILLIP A ,  HOFFMAN DOUGLAS R ,  WEART ILONA F ,  YANG KAIYUAN

    Inventor： SCHORR PHILLIP A ,  HOFFMAN DOUGLAS R ,  WEART ILONA F ,  YANG KAIYUAN

    IPC: A61B19/08 ,  A61F13/02 ,  A61L15/20 ,  A61L15/42 ,  A61L31/14

    CPC classification number: A61K31/00 ,  A61K31/05 ,  A61K31/14 ,  A61K31/155 ,  A61K33/00 ,  A61K33/18 ,  A61K47/32 ,  A61L26/0014 ,  A61L26/0066 ,  C08L33/12

    Abstract: Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. This two step process is time consuming, as each layer must dry before the next one is applied. A skin preparation is provided that immobilizes at least 95 percent of bacteria on the skin and is essentially free of cyanoacrylate. The skin preparation has a fugitive solvent and may also have antimicrobial compounds like iodophors, biguanides, phenols, quaternary amines, antibiotics and metals. This skin preparation may be used without an additional skin sealant or incise applied over it prior to surgery.

    Abstract translation: 通常将皮肤密封剂施用于皮肤制备物上以密封皮肤并在手术切口之前将任何残留的细菌保持在适当的位置。 这种密封胶通常在手术后留在皮肤上。 这两个步骤过程非常耗时，因为在应用下一个层之前，每层必须干燥。 提供了一种皮肤制剂，其将至少95％的细菌固定在皮肤上并且基本上不含氰基丙烯酸酯。 该皮肤制剂具有挥发性溶剂，并且还可以具有抗微生物化合物，如碘伏，双胍，酚，季胺，抗生素和金属。 这种皮肤准备可以在手术前使用，而不需要额外的皮肤密封剂或切口。

    COVERAGE INDICATING TECHNOLOGY FOR SKIN SEALANTS USING TANNATES
    6.
    发明申请
    COVERAGE INDICATING TECHNOLOGY FOR SKIN SEALANTS USING TANNATES 审中-公开
    使用TANNATES的皮肤密封剂的覆盖技术指标

    公开(公告)号：WO2009060327A3

    公开(公告)日：2009-09-24

    申请号：PCT/IB2008054072

    申请日：2008-10-03

    Applicant: KIMBERLY CLARK CO ,  MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    Inventor： MACDONALD JOHN GAVIN ,  SMITH MOLLY K ,  WEART ILONA F ,  SCHORR PHILLIP A

    IPC: A61L24/04 ,  G01N31/22

    CPC classification number: A61K33/18 ,  A61K9/0014 ,  A61K47/26 ,  A61K47/44

    Abstract: A composition having various color changing tannates may be used to indicate that the composition has dried. The tannates change color in contact with an acid. The composition may be, for example, a skin prep, skin sealant, food product, paint or other building material or other product that undergoes a phase change. The tannate may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of tannate in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure.

    Abstract translation: 具有各种变色丹宁酸的组合物可用于表示组合物已干燥。 丹宁酸改变与酸接触的颜色。 组合物可以是例如皮肤制剂，皮肤密封剂，食品，油漆或其他建筑材料或经历相变的其它产品。 丹宁酸可以直接添加到组合物中，并入施用组合物中的海绵中，组合物通过其分配和施用，单独施用或从单独的储存器同时施用。 可以调整组合物中的单宁酸盐的量，以向使用者提供视觉提示和施用范围。

    CECOSTOMIA EN UNA SOLA ETAPA.
    10.
    发明专利
    CECOSTOMIA EN UNA SOLA ETAPA. 未知

    公开(公告)号：MX2014002878A

    公开(公告)日：2014-04-10

    申请号：MX2014002878

    申请日：2012-08-13

    Applicant: KIMBERLY CLARK CO

    Inventor： BAGWELL ALISON S ,  ESTES THOMAS G ,  FEASTER SHAWN R ,  REICHART EMILY A ,  SCHORR PHILLIP A ,  STADELMAN JENNIFER S ,  TAI KOK-MING

    IPC: A61F5/445 ,  A61F5/442 ,  A61J15/00 ,  A61M25/00 ,  A61M25/04 ,  A61M27/00 ,  A61M39/02

    Abstract: La presente divulgación describe un tubo de cecostomía (30) que tiene un cabezal (36) con una abertura (42) y una válvula. Existe un catéter flexible (34) con un lumen (38) que tiene extremos proximal y distal, el extremo proximal del catéter está en comunicación fluida con la abertura en el cabezal, una porción del catéter se extiende lejos del cabezal para definir el extremo distal. Existe un dispositivo retenedor (32) que se proporciona en el extremo distal del catéter. El dispositivo retenedor puede cambiar de forma, de un primer perfil o configuración a un segundo perfil, por ejemplo en respuesta al contacto con un fluido, en donde el segundo perfil es más grande que el primer perfil y el segundo perfil se adapta para retener el tubo de cecostomía en su lugar, en un cuerpo. El dispositivo puede comprender un segundo lumen a través del cual se puede inyectar adhesivo y distribuirlo a lo largo de la superficie externa del catéter. El dispositivo puede colocarse en una sola operación quirúrgica inicial.

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