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    QUANTUM OPTICS PROFILES FOR SCREENING, DIAGNOSIS, AND PROGNOSIS OF DISEASES
    1.
    发明申请
    QUANTUM OPTICS PROFILES FOR SCREENING, DIAGNOSIS, AND PROGNOSIS OF DISEASES 审中-公开

    公开(公告)号：WO2021229531A1

    公开(公告)日：2021-11-18

    申请号：PCT/IB2021/054158

    申请日：2021-05-14

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  KING SAUD UNIVERSITY

    Inventor： NABHOLZ, Jean-Marc ,  BAJIC, Vladimir ,  INCITTI, Roberto ,  ALSALEH, Khalid

    IPC: G16H50/20 ,  G16H50/30 ,  A61B5/00

    Abstract: A method for diagnosing a disease, such as breast cancer, in a biological sample using spectroscopic data is described. The method involves computer-implemented method that runs an algorithm. The algorithm converts spectroscopic vibrational from the sample into a profile, and scores the profile using a pair of reference profiles. Based on the score and a threshold, it can be determined whether the subject from which the sample was obtained has a disease, and, if so, to what extent. The method also allows detection of early and pre-disease states in subjects based on the detection of signal of low concentration analytes that are indicative of early or incipient disease state. The method is non-invasive, non-subjective, and highly specific and sensitive. The method affords the application of a single standard of diagnostic accuracy, independent of the local availability of expert pathologists.

    METHYLATION-BASED BIOMARKERS IN BREAST CANCER SCREENING, DIAGNOSIS, OR PROGNOSIS
    2.
    发明申请
    METHYLATION-BASED BIOMARKERS IN BREAST CANCER SCREENING, DIAGNOSIS, OR PROGNOSIS 审中-公开

    公开(公告)号：WO2019186404A1

    公开(公告)日：2019-10-03

    申请号：PCT/IB2019/052461

    申请日：2019-03-26

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： MANSOUR, Hicham ,  INCITTI, Roberto ,  BAJIC, Vladimir

    IPC: C12Q1/6886

    Abstract: Described are epigenetic biomarkers of breast cancer and their use in breast cancer screening and diagnosing, or to provide disease prognosis in a subject. The epigenetic biomarkers include methylatable regions (MRs), which may be at least one segment from nucleic acid sequences represented in Table 1. Described are also methods of detecting the methylation level of MRs in the subject, the methylation score (mSCORE) of the subject, and using these values to evaluate a breast cancer risk in a subject, or diagnose a subject with breast cancer. Also described are methods of determining a risk of recurrence and disease prognosis in a subject undergoing or having undergone a treatment for breast cancer.

    COMPOSITE BIOMARKERS FOR NON-INVASIVE SCREENING, DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER
    9.
    发明公开
    COMPOSITE BIOMARKERS FOR NON-INVASIVE SCREENING, DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER 有权
    VERBUNDBIOMARKERFÜRNICHTINVASIVES SCREENING，DIAGNOSE UND PROGNOSE VON KOLOREKTALKARZINOM

    公开(公告)号：EP2768980A2

    公开(公告)日：2014-08-27

    申请号：EP12813096.0

    申请日：2012-10-16

    Applicant: King Abdullah University of Science and Technology

    Inventor： MANSOUR, Hicham ,  INCITTI, Roberto ,  BAJIC, Vladimir

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/154

    Abstract: The present invention concerns particular biomarkers for diagnosing and/or prognosticating colorectal cancer, in particular in a non-invasive manner. The methods and compositions concern analysis of methylation patterns of one or more genes from a set of 29 genes identified as described herein. In certain embodiments, the gene set includes at least P15.INK4b, SST, GAS7, CNRIP1, and PIK3CG.

    Abstract translation: 本发明涉及用于诊断和/或预后结直肠癌的特定生物标志物，特别是以非侵入性方式。 所述方法和组合物涉及从如本文所述鉴定的一组29个基因中的一个或多个基因的甲基化模式的分析。 在某些实施方案中，所述基因组包括至少P15.INK4b，SST，GAS7，CNRIP1和PIK3CG。

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