公开(公告)号：US20230173083A1

公开(公告)日：2023-06-08

申请号：US17735371

申请日：2022-05-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwangmeyung KIM ,  Hong Yeol YOON ,  In-Cheol SUN ,  Man Kyu SHIM ,  Hanhee CHO

IPC: A61K47/64 ,  A61K47/65 ,  A61K31/704 ,  A61P35/00

CPC classification number: A61K47/643 ,  A61K31/704 ,  A61K47/65 ,  A61P35/00

Abstract: Disclosed is a prodrug for preventing or treating cancer. The prodrug is mediated by albumin present in the blood to achieve high cancer selectivity for cancer and high stability. Also disclosed is a pharmaceutical composition for preventing or treating cancer including the prodrug. The anticancer prodrug and the pharmaceutical composition form a conjugate with albumin even without using a carrier or delivery vector when injected in vivo. Therefore, the anticancer prodrug and the pharmaceutical composition are effective in preventing or treating cancer, have increased in vivo half-lives, and can accumulate in cancer with increased efficiency to significantly alleviate the side effects of the anticancer drug.