公开(公告)号：US20220323377A1

公开(公告)日：2022-10-13

申请号：US17689665

申请日：2022-03-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Cheol-ho PAN ,  Kwang-hyun CHA ,  Song Yi KOO ,  Eun Ha LEE ,  Hee Ju LEE

IPC: A61K31/122 ,  A61P19/02 ,  A61P29/00 ,  A23L33/00 ,  A23L33/10

Abstract: Provided is a pharmaceutical composition for preventing or treating osteoarthritis, the pharmaceutical composition including, as an active ingredient, obtusifolin, a derivative thereof, or a pharmaceutically acceptable salt thereof. The composition according to an aspect inhibits cartilage destruction-promoting factors and alleviates inflammatory responses, thereby exhibiting significantly excellent effects for preventing or treating osteoarthritis.

公开(公告)号：US20170340690A1

公开(公告)日：2017-11-30

申请号：US15596404

申请日：2017-05-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Cheol-Ho PAN ,  Kyungsu KANG ,  Kwang-Hyun CHA ,  Eun Ha LEE ,  Hee Ju LEE ,  Song Yi KOO ,  Yongsoo CHOI

IPC: A61K36/344 ,  A23L33/135 ,  C12N1/20 ,  A61K35/741 ,  A61K35/00

CPC classification number: A61K36/344 ,  A23L33/135 ,  A23V2002/00 ,  A61K35/741 ,  A61K2035/115 ,  C12N1/20

Abstract: Disclosed is a method for improving intestinal microflora, which includes administering an extract of Codonopsis lanceolata of an amount effective for improving intestinal microflora to a subject in need thereof. The extract can promote the proliferation of beneficial intestinal bacteria and suppress the proliferation of harmful bacteria. Also, the extract can improve intestinal health or intestinal function and improve defecation disorder. In addition, a synergic effect can be obtained when the composition of the present disclosure is used together with probiotics.