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    FORMATION OF STRONG SUPERPOROUS HYDROGELS
    1.
    发明申请
    FORMATION OF STRONG SUPERPOROUS HYDROGELS 审中-公开
    形成强大的超级水力

    公开(公告)号：WO2004096127A2

    公开(公告)日：2004-11-11

    申请号：PCT/US2004011448

    申请日：2004-04-14

    Applicant: KOS LIFE SCIENCES INC

    Inventor： OMIDIAN HOSSEIN ,  GUTIERREZ-ROCCA JOSE

    IPC: A61K9/22 ,  C08F8/44 ,  C08F251/00 ,  C08J9/28 ,  A61K

    CPC classification number: C08F251/00 ,  A61L27/20 ,  A61L27/52 ,  A61L27/56 ,  A61L31/042 ,  A61L31/145 ,  A61L31/146 ,  C08F2/44 ,  C08F8/44 ,  C08F251/02 ,  C08J3/075 ,  C08J9/08 ,  C08J9/28 ,  C08J9/40 ,  C08J2201/024 ,  C08J2201/0546 ,  C08J2203/02 ,  C08J2205/02 ,  C08J2205/022 ,  C08J2300/14 ,  C08J2301/28 ,  C08L2205/04

    Abstract: The present invention features a method for the formation of superporous hydrogels using an ion-equilibration technique. Anionic polysaccharides are included in the hydrogel reaction mixture and cations are introduced either during or after hydrogel formation. Properties of the resulting hydrogel can be subsequently adjusted by treating the cation ­complexed gel with a different cation or cation mixture under equilibrating conditions. It has been found that by properly adjusting the cations and the sequence in which they are used in the equilibration process, superporous hydrogels can be formed that are highly absorbent while maintaining favorable structural properties, including strength, ruggedness, and resiliency. It has also been found that applying appropriate dehydration conditions to them after their formation can further stabilize the superporous hydrogels formed by the method of the invention.

    Abstract translation: 本发明的特征在于使用离子平衡技术形成多孔水凝胶的方法。 在水凝胶反应混合物中包含阴离子多糖，并且在水凝胶形成期间或之后引入阳离子。 随后通过在平衡条件下用不同的阳离子或阳离子混合物处理阳离子络合的凝胶来调节所得水凝胶的性质。 已经发现，通过在平衡过程中适当地调节阳离子及其使用顺序，可以形成高吸水性的多孔水凝胶，同时保持有利的结构特性，包括强度，耐久性和弹性。 还已经发现，在其形成后对它们施加适当的脱水条件可以进一步稳定通过本发明的方法形成的多孔水凝胶。

    FORMATION OF STRONG SUPERPOROUS HYDROGELS
    5.
    发明专利
    FORMATION OF STRONG SUPERPOROUS HYDROGELS 未知

    公开(公告)号：CA2523246C

    公开(公告)日：2009-12-01

    申请号：CA2523246

    申请日：2004-04-14

    Applicant: KOS LIFE SCIENCES INC

    Inventor： GUTIERREZ-ROCCA JOSE ,  OMIDIAN HOSSEIN

    IPC: A61K9/22 ,  A61K31/74 ,  C08F8/44 ,  C08F36/04 ,  C08F251/00 ,  C08J9/28 ,  C08K3/24

    Abstract: The present invention features a method for the formation of superporous hydrogels using an ion-equilibration tech-nique. Anionic polysaccharides are included in the hydrogel reaction mixture and cations are introduced either during or after hydrogel formation. Properties of the resulting hydrogel can be subsequently adjusted by treating the cation complexed gel with a different cation or cation mixture under equilibrating conditions. It has be en found that by properly adjusting the cations and the sequence in which they are used in the equilibration process, superporous hydrogels can be formed that are highly absorbent while maintaining favorable structural properties, including strength, ruggedness, and resiliency. It has also been found that applying ap-propriate dehydration conditions to them after their formation can furthe r stabilize the superporous hydrogels formed by the method of the invention.

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