公开(公告)号：CA3134937A1

公开(公告)日：2020-10-08

申请号：CA3134937

申请日：2020-03-30

Applicant: KOWA CO

Inventor： WATANABE GEN ,  MORIMOTO TOSHIHARU ,  IWATA AKIRA ,  SASAKI HIROTAKA ,  OGAMINO TAKAHISA ,  USUDA KOSUKE ,  OKUDA AYUMU ,  ISHIWATA HIROYUKI ,  TABUNOKI YUICHIRO ,  NISHII KEIGO

IPC: A61K31/437 ,  A61K31/4427 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention provides: a novel compound having a CSF-1R inhibitory activity and an antineoplastic effect; a salt thereof; or a solvate of these. An azaindole derivative represented by general formula (I) (in the formula, A represents a C6-10 aryl ring, an aromatic heterocycle, or an unsaturated heterocycle, A may have one or more substituents that are the same or different, and R represents a C1-3 alkyl group or a saturated heterocyclic group); a salt thereof; or a solvate of these.

公开(公告)号：SG11202109997PA

公开(公告)日：2021-10-28

申请号：SG11202109997P

申请日：2020-03-30

Applicant: KOWA CO

Inventor： WATANABE GEN ,  MORIMOTO TOSHIHARU ,  IWATA AKIRA ,  SASAKI HIROTAKA ,  OGAMINO TAKAHISA ,  USUDA KOSUKE ,  OKUDA AYUMU ,  ISHIWATA HIROYUKI ,  TABUNOKI YUICHIRO ,  NISHII KEIGO

IPC: A61K31/437 ,  A61P35/00 ,  A61K31/4427 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61P35/02 ,  A61P43/00 ,  C07D471/04 ,  C07D519/00

Abstract: To provide a novel compound or a salt thereof or a solvate thereof, having a CSF-1R inhibitory activity and exhibiting antitumor effect.An azaindole derivative of formula (I):whereinA represents a C 6-10 aryl ring, an aromatic heterocycle, or an unsaturated heterocycle, andA optionally has one substituent or more same or different substituents; andR represents a C 1-3 alkyl group or a saturated heterocyclic group,or a salt thereof or a solvate thereof.

公开(公告)号：JP2013253019A

公开(公告)日：2013-12-19

申请号：JP2010217446

申请日：2010-09-28

Applicant: KOWA CO

Inventor： MORIMOTO TOSHIHARU ,  KOSHIZAWA TOMOAKI ,  WATABE GEN ,  FUKUDA TOMOAKI ,  OGIYA TADAAKI ,  SHIMIZU NAHO ,  INOUE KUNIYUKI

IPC: C07D498/04 ,  A61K31/519 ,  A61P3/10 ,  A61P5/50

Abstract: PROBLEM TO BE SOLVED: To provide a new compound having an action to promote insulin secretion from pancreatic &bgr; cells, and useful as a prophylactic and/or therapeutic agent for disorders caused by hyperglycemia, e.g. diabetes mellitus.SOLUTION: There is disclosed a compound expressed by general formula (1) or salt thereof or solvates thereof. In formula, one of A and B represents a nitrogen atom and the other thereof represents a nitrogen atom or CR; X represents an oxygen atom, sulfur atom, -(CH)-N(R)- or -(CH)-CH(R)-; Z represents a nitrogen atom when Y is an oxygen atom or sulfur atom, or Z represents an oxygen atom or sulfur atom when Y is a nitrogen atom; Rto Reach represents a hydrogen atom or another substituent.

公开(公告)号：EP2586781A4

公开(公告)日：2014-01-01

申请号：EP11798249

申请日：2011-06-24

Applicant: KOWA CO

Inventor： MORIMOTO TOSHIHARU ,  KOSHIZAWA TOMOAKI ,  WATANABE GEN ,  OHGIYA TADAAKI ,  YAMASAKI NAO ,  INOUE NORIYUKI

IPC: C07D487/04 ,  A61K31/519 ,  A61P3/10 ,  C07D491/048 ,  C07D495/04

CPC classification number: C07D491/048 ,  C07D487/04 ,  C07D495/04

公开(公告)号：EP2415764A4

公开(公告)日：2012-08-08

申请号：EP10758277

申请日：2010-03-31

Applicant: KOWA CO

Inventor： ASHIKAWA MASANORI ,  TAGASHIRA JUNYA ,  KOKETSU AKIYASU ,  MORIMOTO TOSHIHARU ,  KITAMURA TAKAHIRO ,  TAKEMURA SYUNJI ,  WATANABE GEN ,  NISHIYAMA TATSUAKI ,  GODA SATOSHI ,  YAMABI MASAKI ,  DOI TAKESHI ,  ISHIWATA HIROYUKI

IPC: C07D215/22 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61P7/06 ,  A61P43/00 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D215/42 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/69 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

公开(公告)号：JP2011136942A

公开(公告)日：2011-07-14

申请号：JP2009297783

申请日：2009-12-28

Applicant: Kowa Co ,  興和株式会社

Inventor： MORIMOTO TOSHIHARU ,  TOKUDA OKIHISA ,  SHIBUYA MASAYUKI ,  OGIYA TADAAKI ,  SHIMIZU NAHO ,  INOUE KUNIYUKI

IPC: C07D401/14 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/10 ,  A61P43/00 ,  C07D413/14 ,  C07F5/04

Abstract: PROBLEM TO BE SOLVED: To provide a novel compound that exhibits an effect for promoting insulin secretion from a pancreas β cell and is useful as a preventive and/or therapeutic agent for diseases caused by hyperglycemia, for example, diabetes. SOLUTION: The novel compound is a substituted pyrimidine derivative represented by general formula (1) [wherein the ring A is an optionally substituted 5 to 10-membered heteroaryl group; Q is an oxygen atom or the like; R 1 is a methyl group or the like; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are each independently a hydrogen atom or the like; m is an integer of 0-2; and n is an integer of 1-3] or a salt thereof, or a solvate thereof. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供一种具有促进胰腺β细胞胰岛素分泌的作用的新型化合物，可用作高血糖引起的疾病例如糖尿病的预防和/或治疗剂。 解决方案：新化合物是由通式（1）表示的取代嘧啶衍生物[其中环A是任选取代的5至10元杂芳基; Q是氧原子等; R 1是甲基等; R 2 ，R 3 ，R 4 ，R 5 ，R R 7，R SP＆lt; SP＆gt;，＆lt; SP＆gt; 9＆lt; SP＆gt;和R＆lt; SP＆gt; 10＆lt; SP＆gt;各自独立地为氢原子等; m是0-2的整数; n为1-3的整数）或其盐或其溶剂合物。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：EP2412710A4

公开(公告)日：2012-08-08

申请号：EP10756176

申请日：2010-03-25

Applicant: KOWA CO

Inventor： ASHIKAWA MASANORI ,  MORIMOTO TOSHIHARU ,  YAMADA HAJIME ,  TAKEMURA SHUNJI ,  NISHIYAMA TATSUAKI ,  DOI TAKESHI ,  ISHIWATA HIROYUKI

IPC: C07D221/06 ,  A61K31/4355 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/473 ,  A61K31/4738 ,  A61K31/5383 ,  A61P7/06 ,  A61P43/00 ,  C07D471/04 ,  C07D491/052 ,  C07D491/056 ,  C07D498/04

CPC classification number: C07D221/06 ,  C07D471/04 ,  C07D491/052 ,  C07D491/056 ,  C07D498/04