公开(公告)号：EP3834850A1

公开(公告)日：2021-06-16

申请号：EP19842332.9

申请日：2019-07-24

Applicant: Korea Basic Science Institute

Inventor： CHANG, Ki-Yuk ,  KIM, Chan-Woo ,  HONG, Kwan-Soo ,  LEE, Hyun-Seung ,  KIM, Hyun-Min

IPC: A61K51/10 ,  C07K16/28

Abstract: The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated α v β 3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.

公开(公告)号：EP3916014A1

公开(公告)日：2021-12-01

申请号：EP19938916.4

申请日：2019-07-24

Applicant: Korea Basic Science Institute

Inventor： CHANG, Ki-Yuk ,  HONG, Kwan-Soo ,  KIM, Chan-Woo ,  LEE, Hyun-Seung ,  KIM, Hyun-Min

IPC: C07K16/28 ,  G01N33/574 ,  G01N33/58 ,  G01N33/68 ,  A61K51/10

Abstract: Disclosed are an α v β 3 integrin targeting single-domain antibody and various applications thereof. The α v β 3 integrin targeting single-domain antibody exhibits high binding ability to α v β 3 integrin related to angiogenesis, excellent tissue permeability, and biostability compared to conventional antibodies. Further, the single-domain antibody may be combined with fluorescent particles and thus may be easily measured in vitro, in vivo or ex vivo, and may be effective in detecting angiogenesis and diagnosing angiogenesis related diseases, therefore it may be usefully used in related industries.