公开(公告)号：US20230310534A1

公开(公告)日：2023-10-05

申请号：US18118316

申请日：2023-03-07

Applicant: L'OREAL ,  Yale University

Inventor： Kelly Marie GEORGE ,  Zhi PAN ,  Laurent MARROT ,  Miao WANG ,  Douglas Edgar BRASH ,  Sanjay PREMI ,  Leticia C.P. GONCALVES

IPC: A61K36/704 ,  A61K31/01 ,  A61K36/04 ,  A61K47/12 ,  A61K47/24 ,  A61K36/539 ,  A61K36/287 ,  A61K31/192 ,  A61K31/12 ,  A61K31/353 ,  A61K36/48 ,  A61K31/19 ,  A61K31/44 ,  A61K36/355 ,  A61K31/015 ,  A61K31/366 ,  A61K8/9717 ,  A61K8/44 ,  A61K8/49 ,  A61K8/9789 ,  A61K8/36 ,  A61Q19/00 ,  A61K8/365 ,  A61K8/31 ,  A61K8/40 ,  A61K8/35

CPC classification number: A61K36/704 ,  A61K31/01 ,  A61K36/04 ,  A61K47/12 ,  A61K47/24 ,  A61K36/539 ,  A61K36/287 ,  A61K31/192 ,  A61K31/12 ,  A61K31/353 ,  A61K36/48 ,  A61K31/19 ,  A61K31/44 ,  A61K36/355 ,  A61K31/015 ,  A61K31/366 ,  A61K8/9717 ,  A61K8/44 ,  A61K8/498 ,  A61K8/9789 ,  A61K8/4926 ,  A61K8/36 ,  A61Q19/004 ,  A61K8/365 ,  A61K8/31 ,  A61K8/40 ,  A61K8/35

Abstract: A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.

公开(公告)号：US20190262248A1

公开(公告)日：2019-08-29

申请号：US15907436

申请日：2018-02-28

Applicant: L'OREAL

Inventor： Sara Robyn Muenz YOUSSEF ,  Kelly Marie GEORGE ,  Carol Ragai ELMASRY ,  Allison ELDER

IPC: A61K8/44 ,  A61K8/34 ,  A61K8/37 ,  A61K8/86 ,  A61K8/46 ,  A61Q5/12 ,  A61Q5/02

Abstract: A cosmetic composition and a method of preparing the cosmetic composition are provided. The method includes mixing at least one sulfate-free surfactant, at least one thickener, at least one hydrophilic emollient to form a mixture; and adding solvent to the mixture. The cosmetic composition is a clear, flowable semi-solid, and converts to a non-flowable semi-solid upon rubbing.

公开(公告)号：US20190175679A1

公开(公告)日：2019-06-13

申请号：US15840580

申请日：2017-12-13

Applicant: L'OREAL ,  Yale University

Inventor： Kelly Marie GEORGE ,  Zhi Pan ,  Laurent Marrot ,  Miao Wang ,  Douglas Edgar Brash ,  Sanjay Premi ,  Leticia C.P. Goncalves

IPC: A61K36/704 ,  A61K31/366 ,  A61K36/04 ,  A61K47/12 ,  A61K47/24 ,  A61K36/539 ,  A61K36/287 ,  A61K31/192 ,  A61K31/12 ,  A61K31/353 ,  A61K36/48 ,  A61K31/19 ,  A61K31/44 ,  A61K36/355 ,  A61K31/015 ,  A61K31/01

Abstract: A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.