公开(公告)号：US20180142020A1

公开(公告)日：2018-05-24

申请号：US15546406

申请日：2016-01-27

Applicant: LAVA THERAPEUTICS B.V.

Inventor： Johannes Jelle VAN DER VLIET ,  Tanja Denise DE GRUIJL ,  Hendrik Marinus Willem VERHEUL ,  Renée Cornelia Gerarda DE BRUIN ,  Roeland LAMERIS

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2809 ,  C07K16/2833 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/75

Abstract: The invention relates to compounds, in particular polypeptides that specifically bind to the non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The invention in particular relates to such compounds and polypeptides comprising or consisting of at least one single domain antibody, and wherein at least one single domain antibody specifically binds to CD1d. Also provided is for methods and use employing such compounds, polypeptides and/or single-domain antibodies.