公开(公告)号：WO2020060406A1

公开(公告)日：2020-03-26

申请号：PCT/NL2019/050625

申请日：2019-09-19

Applicant: LAVA THERAPEUTICS B.V.

Inventor： DE WEERDT, Iris ,  KATER, Arnon Philip ,  PARREN, Paul Willem Henri Ida ,  DE GRUIJL, Tanja Denise ,  VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04

Abstract: The present invention relatestonovel methodsfor the treatment of hematological malignancies. In particular, the invention relatesto the treatment of hematological malignancies using antibodiescomprising a first binding moiety that is able to bind human CD1d and a second binding moiety that is able to bind the human Vγ9Vδ2-TCR.

公开(公告)号：WO2020060405A1

公开(公告)日：2020-03-26

申请号：PCT/NL2019/050624

申请日：2019-09-19

Applicant: LAVA THERAPEUTICS B.V.

Inventor： VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland ,  DE GRUIJL, Tanja Denise ,  PARREN, Paul Willem Henri Ida

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04

Abstract: The present invention relates to the field of immunology, more in particular to the field of binding moieties and/or immunoglobulins which bind to human CD1d, including antibodies and fragments thereof that modify CD1d-mediated biological functions such as enhanced activation and reduced activation of CD1d-restricted T cells, including the natural killer T- cells and gamma-delta T-cells, and modulation of the function of cells expressing CD1d. The invention also relates to bi-, tri-or multi-specific immunoglobulins that bind to CD1d and a gamma-delta TCR and/or a tumor target. The invention further relates to pharmaceutical preparations and use of such mono-, bi-,and tri-or multi-specific binding moieties and/or immunoglobulins in the treatment of diseases or disorders.

公开(公告)号：EP3853256A1

公开(公告)日：2021-07-28

申请号：EP19831921.2

申请日：2019-09-19

Applicant: Lava Therapeutics B.V.

Inventor： VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland ,  DE GRUIJL, Tanja Denise ,  PARREN, Paul Willem Henri Ida

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04

公开(公告)号：EP3853255A1

公开(公告)日：2021-07-28

申请号：EP19828845.8

申请日：2019-09-19

Applicant: Lava Therapeutics B.V.

Inventor： DE WEERDT, Iris ,  KATER, Arnon Philip ,  PARREN, Paul Willem Henri Ida ,  DE GRUIJL, Tanja Denise ,  VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04