公开(公告)号：AU2002217604A1

公开(公告)日：2003-07-15

申请号：AU2002217604

申请日：2001-12-29

Applicant: LEE YONG TAE

Inventor： LEE HYE-SUNG ,  KIM YOO-JUNG ,  LEE YONG-TAE

IPC: C07F9/165 ,  C07F9/24 ,  C07F9/58 ,  G01N33/53

Abstract: The present invention relates to a process for preparing haptens for immunoassay of phosphorothioate pesticides, which comprises the steps of reacting O-methyl(ethyl) dichlorothiophosphate with a phenolic compound to obtain O-methyl(ethyl) O-aryl chlorothiophosphate, and reacting the O-(methyl)ethyl O-aryl chlorothiophosphate thus obtained with aminocarboxylic acid to give desired haptens. In accordance with the present invention, haptens having a structure of O-methyl(ethyl) O-aryl N-(carboxyalkyl)phosphoramidothioate or O-methyl(ethyl) O-aryl N-alkyl-N-(carboxyalkyl)phosphoramidothioate can be simply prepared with a high yield by employing two-step processes in a cost-efficient manner.