公开(公告)号：WO2017013138A8

公开(公告)日：2017-01-26

申请号：PCT/EP2016/067218

申请日：2016-07-19

Applicant: LIFE TECHNOLOGIES AS

Inventor： FONNUM, Geir ,  LUNDBERG, Per, Nils, Pontus, ,  GÖKMEN, Muhammed, Talha ,  LARSEN, Synne ,  GLOMM, Wilhelm ,  JOHNSEN, Heidi ,  SCHMID, Ruth ,  KILAAS, Lars

IPC: C08F120/54 ,  C08F2/38 ,  C08F265/10

Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non- crosslinked oligomers of poly Ν,Ν-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.

Abstract translation: 本发明涉及单分散交联水凝胶聚合物颗粒，其包含由（a）亲水性乙烯基单体形成的聚合物; 和（b）包含至少两个乙烯基的交联剂。 本发明还涉及包含多个N，N-二甲基丙烯酰胺的非交联低聚物的Z-平均直径为100nm至1500nm的单分散种子颗粒。 还提供了形成单分散交联水凝胶聚合物颗粒和单分散种子颗粒的方法。

公开(公告)号：WO2017013138A1

公开(公告)日：2017-01-26

申请号：PCT/EP2016/067218

申请日：2016-07-19

Applicant: LIFE TECHNOLOGIES AS

Inventor： FONNUM, Geir ,  LUNDBERG, Per, Nils, Pontus, ,  GÖKMEN, Muhammed, Talha ,  LARSEN, Synne ,  GLOMM, Wilhelm ,  JOHNSEN, Heidi ,  SCHMID, Ruth ,  KILAAS, Lars

IPC: C08F120/54 ,  C08F2/38 ,  C08F265/10

CPC classification number: C08F120/54 ,  C08F265/10 ,  C08F220/56

Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non- crosslinked oligomers of poly Ν,Ν-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.

Abstract translation: 本发明涉及包含由（a）亲水性乙烯基单体形成的聚合物的单分散交联水凝胶聚合物颗粒; 和（b）包含至少两个乙烯基的交联剂。 本发明还涉及Z平均直径为100nm至1500nm的单分散种子颗粒，其包含多个未交联的聚N，N-二甲基丙烯酰胺的低聚物。 还提供了形成单分散交联水凝胶聚合物颗粒和单分散种子颗粒的方法。

公开(公告)号：EP3325522A1

公开(公告)日：2018-05-30

申请号：EP16739524.3

申请日：2016-07-19

Applicant: Life Technologies AS

Inventor： FONNUM, Geir ,  LUNDBERG, Per, Nils, Pontus, ,  GÖKMEN, Muhammed, Talha ,  LARSEN, Synne ,  GLOMM, Wilhelm ,  JOHNSEN, Heidi ,  SCHMID, Ruth ,  KILAAS, Lars

IPC: C08F120/54 ,  C08F2/38 ,  C08F265/10

CPC classification number: C08F265/10 ,  C08F120/54 ,  C08F265/06 ,  C08F220/56

Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.