公开(公告)号：AU713235B2

公开(公告)日：1999-11-25

申请号：AU7382896

申请日：1996-09-27

Applicant: LILLY CO ELI ,  COR THERAPEUTICS INC

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M ,  SCHOTTEN THEO ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I):wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

公开(公告)号：AU7382896A

公开(公告)日：1997-04-17

申请号：AU7382896

申请日：1996-09-27

Applicant: COR THERAPEUTICS INC ,  LILLY CO ELI

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M JR ,  SCHOTTEN THEO ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I):wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

公开(公告)号：NZ320963A

公开(公告)日：1999-08-30

申请号：NZ32096396

申请日：1996-09-27

Applicant: LILLY CO ELI ,  COR THERAPEUTICS INC

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M ,  SCHOTTEN THEO ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06 ,  C07D221/00

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I):wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

公开(公告)号：CA2143532A1

公开(公告)日：1995-09-05

申请号：CA2143532

申请日：1995-02-28

Applicant: LILLY CO ELI

Inventor： RUTERBORIES KENNETH J ,  SHUMAN ROBERT T

IPC: A61K38/55 ,  A61K31/40 ,  A61K38/00 ,  A61P7/02 ,  C07C279/06 ,  C07D207/16 ,  C07D401/06 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K5/097 ,  A61K38/05 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/395

Abstract: This invention relates to bisulfite adducts of L-arginine aldehyde derivatives, the adducts having the formula I where M, X and Y have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors and thromoembolic disorder agents.

公开(公告)号：AT274499T

公开(公告)日：2004-09-15

申请号：AT96936093

申请日：1996-09-27

Applicant: LILLY CO ELI ,  MILLENNIUM PHARM INC

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUEHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M ,  SCHOTTEN THEO ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I):wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

公开(公告)号：MX9802379A

公开(公告)日：1998-08-30

申请号：MX9802379

申请日：1996-09-27

Applicant: LILLY CO ELI ,  COR THERAPEUITCS INC

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M ,  SCHOTTEN THEO

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06 ,  C07D263/00 ,  C07D221/00

Abstract: Esta invencion se refiere a ciertos compuestos espirocíclicos substituidos con una funcionalidad ácida o básica, que es util en la inhibicion de agregacion de plaquetas.